دانلود مقالات ISI درباره Shm, Somatic Hypermutation + ترجمه فارسی

MSPrecise: A molecular diagnostic test for multiple sclerosis using next generation sequencing

Keywords: RRMS, relapsing–remitting multiple sclerosis; OND, other neurological disease; MS, multiple sclerosis; CNS, central nervous system; SHM, somatic hypermutation; CSF, cerebrospinal fluid; VH4, variable heavy chain family 4; NGS, next generation sequencing;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2015 سفارش ترجمه

Targeting poly(ADP-ribose)polymerase1 in neurological diseases: A promising trove for new pharmacological interventions to enter clinical translation

Keywords: PARP1, poly(ADP-ribose)polymerase1; PARylation, poly(ADP-ribosyl)ation; PARG, poly(ADP-ribose) glycohydrolase; TBI, traumatic brain injury; XRCC1, X-ray repair cross-complementing protein1; SHM, somatic hypermutation; IGC, immunoglobulin gene conversion;

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2014 سفارش ترجمه

In Vitro Affinity Maturation of an Anti-PSA Antibody for Prostate Cancer Diagnostic Assay

Keywords: PSA, prostate-specific antigen; scFv, single-chain variable fragment; CDR, complementarity-determining region; BPH, benign prostatic hyperplasia; fPSA, free PSA; tPSA, total PSA; aPSA, activatable PSA; mAb, monoclonal antibody; SHM, somatic hypermutation;

دانلود رایگان متن کامل مقاله ISI 18 صفحه سال انتشار : 2011 سفارش ترجمه

TXNIP regulates germinal center generation by suppressing BCL-6 expression

Keywords: CSR, class-switch recombination; DNP, 2,4-dinitrophenyl; FDC, follicular dendritic cell; GC, germinal center; KLH, keyhole limpet hemocyanin; MC, mantle zone; PNA, lectin peanut agglutinin; SHM, somatic hypermutation; TD, T cell-dependent; TI, T cell-inde

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2010 سفارش ترجمه

The amino acid residue at position 95 and the third CDR region in the H chain determine the ceiling affinity and the maturation pathway of an anti-(4-hydroxy-3-nitrophenyl)acetyl antibody

Keywords: aa, amino acid; CDR 3H, third CDR of H chain; NP, (4-hydroxy-3-nitrophenyl)acetyl; PC, phosphocholine; phOx, 2-phenyl oxazolone; SHM, somatic hypermutation; W33L, mutation from Trp to Leu at position 33Antibody; Affinity maturation; Somatic hypermutation;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2010 سفارش ترجمه

Cloning and expression of murine Ig genes from single B cells

Keywords: Ig, immunoglobulin; IgH, Ig heavy chain; IgL, Ig light chain; V, variable; D, diversity; J, joining; SHM, somatic hypermutation; CDR, complementarity determining regionRecombinant monoclonal antibodies; Single cell PCR; Immunoglobulin gene repertoire

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2009 سفارش ترجمه

The role of Blimp-1 in the GC reaction: Differential expression of Blimp-1 upon immunization with TD and TI antigens

Keywords: BCR, B cell receptor; Blimp-1, B lymphocyte-induced maturation protein; CSA, chicken serum albumin; CT, cholera toxin; Dx, dextran B512; GC, germinal center; NP, nitrophenyl; PNA, peanut agglutinin; SHM, somatic hypermutation; TD, thymus dependent; TI, th

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2007 سفارش ترجمه

Absence of DNA polymerase θ results in decreased somatic hypermutation frequency and altered mutation patterns in Ig genes

Keywords: Low fidelity DNA polymerase; Immunoglobulin gene; Somatic hypermutation; Class switch recombinationPOLQ, DNA polymerase θ; AID, activation-induced cytidine deaminase; UNG, uracil DNA glycosylase; SHM, somatic hypermutation; CSR, class switch recombination

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2006 سفارش ترجمه

Forced expression of AID facilitates the isolation of class switch variants from hybridoma cells

Keywords: AID, activation-induced cytidine deaminase; Ars, p-azophenylarsonate; CSR, class switch recombination; ESA, ELISA spot assay; Hs, hotspots; Ig, immunoglobulin; SHM, somatic hypermutation; Ts, transition mutations.AID; CSR; hybridoma

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2006 سفارش ترجمه

Episomal vectors to monitor and induce somatic hypermutation in human Burkitt-Lymphoma cell lines

Keywords: BL, Burkitt-Lymphoma; CSR, class switch recombination; SHM, somatic hypermutation; AID, activation-induced cytidine deaminase; IRES, internal ribosome entry site; Dox, DoxycyclineSomatic hypermutation; Activation induced cytidine deaminase; Burkitt's Lymp

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2006 سفارش ترجمه

MDM2 can interact with the C-terminus of AID but it is inessential for antibody diversification in DT40 B cells

Keywords: AID, activation-induced deaminase; CSR, class switch recombination; EGFP, enhanced green fluorescent protein; Ig, immunoglobulin; IGC, immunoglobulin gene conversion; MDM2, murine double minute 2; NES, nuclear export sequence; SHM, somatic hypermutation;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2006 سفارش ترجمه

Biased dA/dT somatic hypermutation as regulated by the heavy chain intronic iEμ enhancer and 3′Eα enhancers in human lymphoblastoid B cells

Keywords: AID, activation-induced cytidine deaminase; BCR, B cell receptor; BER, base excision repair; DSB, double strand break; iEμ, intronic Ig μ enhancer; Ig, immunoglobulin; MMR, mismatch repair; SHM, somatic hypermutation; SSCP, single-strand conformational po

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2006 سفارش ترجمه

Recombinase, chromosomal translocations and lymphoid neoplasia: Targeting mistakes and repair failures

Keywords: BE, broken end; BL, Burkitt's lymphoma; B-NHL, B-cell Non-Hodgkin's lymphoma; CE, coding end; CJ, coding joint; CSR, class-switch recombination; DSB, double-strand break; NHEJ, non-homologous end-joining; SHM, somatic hypermutation; HJ, hybrid joint; RSS,

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2006 سفارش ترجمه

Identification of the activation-induced cytidine deaminase gene from zebrafish: an evolutionary analysis

Keywords: Activation-induced cytidine deaminase; Class switch recombination; C-terminal; Deaminase motif; Evolution; Genomic structure; Somatic hypermutation; Zebrafish; AID(AICDA), activation-induced cytidine deaminase; CSR, class switch recombination; HIGM, hyper

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2005 سفارش ترجمه