Keywords: هموگلوبین سلول سقط; TLR4; Toll-like receptor; HO-1; heme oxygenase; SS RBCs; homozygous sickle cells; PS; phosphatidylserine; Nrf2; nuclear factor (erythroid-derived 2)-like 2; Sickle cell hemoglobin; Microparticles; Pseudoperoxidase; Heme oxidation; Ferryl hemoglobin;