دانلود مقالات ISI درباره Sirtuin + ترجمه فارسی

NAD+ dependent deacetylase Sirtuin 5 rescues the innate inflammatory response of endotoxin tolerant macrophages by promoting acetylation of p65

Keywords: Sirtuin; SIRT5; Sepsis; NF-κB; Hypo-inflammation; Proinflammatory cytokine;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2017 سفارش ترجمه

Inhibiting poly ADP-ribosylation increases fatty acid oxidation and protects against fatty liver disease

Keywords: Non-alcoholic fatty liver disease; Poly ADP-ribosylation; Sirtuin; PARP inhibitor; PARylation; NAD;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2017 سفارش ترجمه

Muscle-specific knockout of general control of amino acid synthesis 5 (GCN5) does not enhance basal or endurance exercise-induced mitochondrial adaptation

Keywords: Acetylation; GCN5; Mitochondria; SIRT1; Deacetylase; PGC-1α; AMP; adenosine monophosphate; Ca2+; calcium; CBP; CREB-binding protein; Cre-MCK; creatine kinase promoter; CHO; carbohydrate; DAC; deacetylase; ETC; electron transport chain; ExT; endurance exe

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2017 سفارش ترجمه

Sirtuin 6 prevents matrix degradation through inhibition of the NF-κB pathway in intervertebral disc degeneration

Keywords: AF; annulus fibrosus; ECM; extracellular matrix; IDD; intervertebral disc degeneration; IL-1β; interleukin-1 beta; IVD; intervertebral disc; LBP; lower back pain; MMP; matrix metalloproteinase; NAD; nicotinamide adenine dinucleotide; SIRT; sirtuin; Inter

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2017 سفارش ترجمه

Multiple pathways of SIRT6 at the crossroads in the control of longevity, cancer, and cardiovascular diseases

Keywords: ALP; alkaline phosphatase; AMPK; AMP-activated protein kinase; Ang II; angiotensin II; BER; base excision repair; cAMP; cyclic adenosine monophosphate; CDK; cyclin-dependent kinase; CHIP; carboxyl terminus of Hsp70-interacting protein; CLL; chronic lympho

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2017 سفارش ترجمه

EphB2 signaling-mediated Sirt3 expression reduces MSC senescence by maintaining mitochondrial ROS homeostasis

Keywords: Eph; Ephrin receptor; Sirt; sirtuin; MnSOD; mitochondrial localized superoxide dismutase 2; UCB-MSC; umbilical cord blood derived mesenchymal stem cell; mtROS; mitochondrial reactive oxygen species; NT; non-targeting; siRNA; small interference ribose nucl

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2017 سفارش ترجمه

Bivalent SIRT1 inhibitors

Keywords: β-NAD+; β-nicotinamide adenine dinucleotide; NAM; nicotinamide; 2′-O-AADPR; 2′-O-acyl-ADP-ribose; RP-HPLC; reversed-phase high performance liquid chromatography; HRMS; high-resolution mass spectrometry; EDC-MeI; 1-(3-dimethylaminopropyl)-3-ethylcarb

دانلود رایگان متن کامل مقاله ISI 21 صفحه سال انتشار : 2017 سفارش ترجمه

A Sir2 family protein Rv1151c deacetylates HU to alter its DNA binding mode in Mycobacterium tuberculosis

Keywords: HU; Nucleoid associated proteins; Sirtuin; Rv1151c; Acetylation; Deacetylation; Mtb; Mycobacterium tuberculosis; MtHU; Mycobacterium tuberculosis HU; MtHUAc; acetylated MtHU; MtHUdAc; deacetylated MtHU;

دانلود رایگان متن کامل مقاله ISI 23 صفحه سال انتشار : 2017 سفارش ترجمه

A novel SIRT1 inhibitor, 4bb induces apoptosis in HCT116 human colon carcinoma cells partially by activating p53

Keywords: Small molecule; HDAC inhibitor; Cell death; Bax; Caspase 3; Sirtuin;

دانلود رایگان متن کامل مقاله ISI 23 صفحه سال انتشار : 2017 سفارش ترجمه

Metabolic roles of poly(ADP-ribose) polymerases

Keywords: ABCA1; ATP-binding cassette sub-family A member 1; ACACA; acetyl-CoA carboxylase alpha; ACBD3; acyl-CoA binding domain containing 3; ACLY; ATP citrate lyase; ADP; adenosine diphosphate; ADPR; ADP-ribose; AFLD; alcoholic fatty liver disease; AIF; apoptosis

دانلود رایگان متن کامل مقاله ISI 27 صفحه سال انتشار : 2017 سفارش ترجمه

Sirtuin 6 protects the brain from cerebral ischemia/reperfusion injury through NRF2 activation

Keywords: ARE; antioxidant response element; DCF; 2′7′-dichloro-fluorescein; HO-1; heme oxygenase-1; I/R; ischemia/reperfusion; LDH; lactate dehydrogenase; MCAO; middle cerebral artery occlusion; MDA; malondialdehyde; OGD/R; oxygen-glucose-deprivation/reoxygena

دانلود رایگان متن کامل مقاله ISI 31 صفحه سال انتشار : 2017 سفارش ترجمه

Cytochrome P450-derived eicosanoids and heart function

Keywords: AA; arachidonic acid; ACS; acute coronary syndrome; ALA; alpha-linolenic acid; AMI; acute myocardial infarction; AMPK; 5′ adenosine monophosphate-activated protein kinase; Ang II; angiotensin II; ANP; atrial natriuretic peptide; BaP; benzo(α)pyrene; BK

دانلود رایگان متن کامل مقاله ISI 37 صفحه سال انتشار : 2017 سفارش ترجمه

Interplay between SIRT1 and hepatitis B virus X protein in the activation of viral transcription

Keywords: Hepatitis B virus; Sirtuin; HBx; cccDNA; SIRT1;

دانلود رایگان متن کامل مقاله ISI 45 صفحه سال انتشار : 2017 سفارش ترجمه

A nutritional perspective on UCP1-dependent thermogenesis

Keywords: UCP1; Brown adipose tissue; White adipose tissue browning; Diet-induced thermogenesis; Bioactive food compounds; Nutrigenetics; AMP; adenosine monophosphate; AMPK; adenosine monophosphate-activated protein kinase; ADRB3; beta-3 adrenergic receptor; BAT; b

دانلود رایگان متن کامل مقاله ISI 58 صفحه سال انتشار : 2017 سفارش ترجمه

Anti-inflammatory effects of sucrose-derived oligosaccharides produced by a constitutive mutant L. mesenteroides B-512FMCM dextransucrase in high fat diet-fed mice

Keywords: Inflammation; Insulin resistance; Sirtuin; Sucrose-derived oligosaccharide;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2016 سفارش ترجمه

Sirtuin-2 mediates male specific neuronal injury following experimental cardiac arrest through activation of TRPM2 ion channels

Keywords: TRPM2; Sirtuin; Cerebral ischemia; Cardiac arrest

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2016 سفارش ترجمه

Cyclic peptide-based potent and selective SIRT1/2 dual inhibitors harboring Nε-thioacetyl-lysine

Keywords: β-NAD+; β-nicotinamide adenine dinucleotide; MBHA; 4-methylbenzhydrylamine; SPPS; solid phase peptide synthesis; DMF; N,N-dimethylformamide; TFA; trifluoroacetic acid; DCM; dichloromethane; HBTU; 2-(1H-benzotriazole-1-yl)-1,1,3,3-tetramethylaminium hexa

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2016 سفارش ترجمه

PEP-1-SIRT2-induced matrix metalloproteinase-1 and -13 modulates type II collagen expression via ERK signaling in rabbit articular chondrocytes

Keywords: PB; phosphate-buffered saline; MMPs; Matrix Metalloproteinases; ECM; extracellular matrix; ERK; extracellular regulated kinase; OA; Osteoarthritis; RA; rheumatoid arthritis; SIRT; Sirtuin; MAPK; mitogen-activated protein kinase; JNK; c-Jun N-terminal kina

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2016 سفارش ترجمه

The glucagon like peptide 1 analogue, exendin-4, attenuates oxidative stress-induced retinal cell death in early diabetic rats through promoting Sirt1 and Sirt3 expression

Keywords: Diabetic retinopathy; Exendin-4; Sirtuin; Oxidative stress; Cell death;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2016 سفارش ترجمه

Nicotinamide adenine dinucleotide homeostasis and signalling in heart disease: Pathophysiological implications and therapeutic potential

Keywords: Heart failure; Energy metabolism; Nicotinamide adenine dinucleotide; Sirtuin; PARP; CD38Insuffisance cardiaque; Métabolisme énergétique; Nicotinamide adénine dinucléotide; Sirtuine; PARP; CD38ADP, adenosine diphosphate; ADPR, ADP-ribose; ART, ADP-ribosyl

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2016 سفارش ترجمه

Sirtuin1 Regulates the Stem Cell Therapeutic Effects on Regenerative Capability for Treating Severe Heart Failure in a Juvenile Animal Model

Keywords: HF; heart failure; HGF; hepatocyte growth factor; HIF; hypoxia-induced factor; KD; knockdown; LVEF; left ventricular ejection fraction; MRI; magnetic resonance imaging; NF-κB; nuclear factor-κB; SDF-1; stromal cell-derived factor-1; SIRT; sirtuin; SS;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2016 سفارش ترجمه

Archival ReportHippocampal Sirtuin 1 Signaling Mediates Depression-like Behavior

Keywords: Anxiety; Chronic stress; Dendritic atrophy; Depression; Hippocampus; Sirtuin;

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2016 سفارش ترجمه

Research ArticleNMNAT3 is involved in the protective effect of SIRT3 in Ang II-induced cardiac hypertrophy

Keywords: SIRT; sirtuin; NMNAT; nicotinamide mononucleotide adenylyltransferase; NAMPT; nicotinamide phosphoribosyltransferase; NAD; nicotinamide adenine dinucleotide; Ang II; angiotensin II; ANF; atrial natriuretic factor; BNP; brain natriuretic polypeptide; NRCMs

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2016 سفارش ترجمه

ATRIP Deacetylation by SIRT2 Drives ATR Checkpoint Activation by Promoting Binding to RPA-ssDNA

Keywords: sirtuin; metabolism; SIRT2; ATR; ATRIP; replication stress; DNA replication; DNA damage response; DNA repair; acetylome; cell cycle; checkpoint

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2016 سفارش ترجمه

C. elegans lifespan extension by osmotic stress requires FUdR, base excision repair, FOXO, and sirtuins

Keywords: C. elegans; FUdR; Hypertonic stress; FOXO; Sirtuin; Hormesis;

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2016 سفارش ترجمه

A FRET-based assay for screening SIRT5 specific modulators

Keywords: Sirtuin; Deacetylation; Desuccinylation; Fluorogenic assay; FRET assay

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2015 سفارش ترجمه

Reduced SIRT1 expression correlates with enhanced oxidative stress in compensated and decompensated heart failure

Keywords: Sirtuin; RT-qPCR; TAS; TOS; OSI; HDL

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2015 سفارش ترجمه

A FRET-based assay for screening SIRT6 modulators

Keywords: Sirtuin; Deacetylation; Defatty-acylation; Fluorogenic assay; FRET assay;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2015 سفارش ترجمه

Novel thiourea-based sirtuin inhibitory warheads

Keywords: β-NAD+; β-nicotinamide adenine dinucleotide; 2′-O-AADPR; 2′-O-acyl-ADP-ribose; IC50; the inhibitor concentration at which an enzymatic reaction velocity is reduced by 50%; SPPS; solid phase peptide synthesis; RP-HPLC; reversed-phase high pressure li

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2015 سفارش ترجمه

SIRT1 gene is associated with cardiovascular disease in the Iranian population

Keywords: Sirtuin; SIRT1; Cardiovascular disease (CVD); Genetic polymorphism

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2015 سفارش ترجمه

Sirtuin 1 participates in the process of age-related retinal degeneration

Keywords: Visual function; Sirtuin; BDNF; Apoptosis; Retina;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2015 سفارش ترجمه

Discovery of bicyclic pyrazoles as class III histone deacetylase SIRT1 and SIRT2 inhibitors

Keywords: DJSXAFBEVHGPLR-UHFFFAOYSA-N; Sirtuin; SIRT; Inhibitor; Pyrazole; Docking;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2015 سفارش ترجمه

Depletion of SIRT6 causes cellular senescence, DNA damage, and telomere dysfunction in human chondrocytes

Keywords: Sirtuin; SIRT6; Chondrocyte; Senescence; DNA damage; Telomere dysfunction;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2015 سفارش ترجمه

Reciprocal regulation by hypoxia-inducible factor-2α and the NAMPT-NAD+-SIRT axis in articular chondrocytes is involved in osteoarthritis

Keywords: Hypoxia-inducible factor (HIF); NAD+ biosynthesis; Sirtuin; Chondrocytes; Osteoarthritis;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2015 سفارش ترجمه

SIRT1 inhibition in pancreatic cancer models: Contrasting effects in vitro and in vivo

Keywords: 6-Chloro-2,3,4,9-tetrahydro-1H-Carbazole-1-carboxamide (EX527) (PubChem CID: 5113032)Pancreatic cancer; EX527; SIRT1; Sirtuin; Gemcitabine; Tumour resistance

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2015 سفارش ترجمه

Poly(ADP-ribose) polymerases as modulators of mitochondrial activity

Keywords: poly(ADP-ribose) polymerase; NAD+; AMP activated kinase; Sirtuin; hypoxia-inducible factor; nuclear respiratory factor

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2015 سفارش ترجمه

Posttranslational modification of Sirt6 activity by peroxynitrite

Keywords: HIF-1α; hypoxia-inducible factor-1α; HRMEC; human retinal microvascular endothelial cell; Sirt; sirtuin; LPS; lipopolysaccharide; NAD; nicotinamide adenine dinucleotide; NT; nitrotyrosine; PARP-1; mono-ADP-ribosylating poly(ADP-ribose) polymerase 1; SIN

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2015 سفارش ترجمه

Research ArticleInterferon regulatory factor 9 is a key mediator of hepatic ischemia/reperfusion injury

Keywords: I/R; ischemia and reperfusion; IRF; interferon regulatory factor; KO; knockout; SIRT; sirtuin; LTx; liver transplantation; ISGF3; interferon-stimulated gene factor 3; ALT; alanine amino transferase; AST; aspartate amino transferase; TNF; tumour necrosis f

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2015 سفارش ترجمه

The histone deacetylase inhibitor cambinol prevents acidic pHe-induced anterograde lysosome trafficking independently of sirtuin activity

Keywords: SIRT; sirtuin; NHE; sodium proton exchanger; Tro; troglitazone; JLA; juxtanuclear lysosome aggregation; EIPA; ethyl-isopropyl amiloride; LAMP-1; lysosome associated membrane protein 1; HDAC; histone deacetylase; pHe; extracellular pH; MTOC; microtubule or

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2015 سفارش ترجمه

Enhanced insulin sensitivity in skeletal muscle and liver by physiological overexpression of SIRT6

Keywords: SIRT6 overexpression; Sirtuin; Insulin sensitivity; Glucose homeostasis; DiabetesBAC, bacterial artificial chromosome; T2DM, type 2 diabetes mellitus; HCD, high-caloric diet; IPGTT, intraperitoneal glucose tolerance test; IPPTT, intraperitoneal pyruvate t

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2015 سفارش ترجمه

Epigenetics and muscle dysfunction in chronic obstructive pulmonary disease

Keywords: ANOVA; Analysis of variance; COPD; chronic obstructive pulmonary disease; MyHC; myosin heavy chain; CH3; methyl group; coA; coenzyme A; CpG; cytosine and guanosine nucleotides; DNA; deoxyribonucleic acid; HSP; heat shock proteins; HTAs; histone acetyltran

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2015 سفارش ترجمه

Sirtuin-6 inhibits cardiac fibroblasts differentiation into myofibroblasts via inactivation of nuclear factor κB signaling

Keywords: AAC; abdominal aortic constriction; Ang II; angiotensin II; CCK-8; Cell Counting Kit-8; CF; cardiac fibroblast; DAPI; 4′,6-diamidino-2-phenylindol; ECM; extracellular matrix; EGFP; enhanced green fluorescent protein; EMSA; electrophoretic mobility shift

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2015 سفارش ترجمه

Sirtuins in vascular diseases: Emerging roles and therapeutic potential

Keywords: ACE; angiotensin converting enzyme; AICAR; 5-amino-4-imidazolecarboxamide riboside; AMPK; AMP-activated protein kinase; Ang II; angiotensin II; ApoE; apolipoprotein E; AT1R; angiotensin II type 1 receptor; ATM; ataxia telangiectasia mutated; ATP; adenosin

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2015 سفارش ترجمه

Redox-regulated fate of neural stem progenitor cells

Keywords: ARE; antioxidant response element; bHLH; basic helix-loop-helix; BMI1; B lymphoma Mo-MLV insertion region 1 homolog; CtBPs; C-terminal binding proteins; DLL4; delta-like protein 4; DVL; disheveled; DOUX; dual oxidases; ES; embryonic stem cells; EGFR; epid

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2015 سفارش ترجمه

Design, synthesis and structure–activity relationship studies of novel sirtuin 2 (SIRT2) inhibitors with a benzamide skeleton

Keywords: Sirtuin; SIRT2

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2015 سفارش ترجمه

Fluoride induces oxidative damage and SIRT1/autophagy through ROS-mediated JNK signaling

Keywords: Fluorosis; Ameloblast; ROS; Oxidative damage; JNK; Sirtuin; Autophagy;

دانلود رایگان متن کامل مقاله ISI 17 صفحه سال انتشار : 2015 سفارش ترجمه

A mini-review on Sirtuin activity assays

Keywords: Assays; Deacetylation; Deacylation; Histone deacetylase; Sirtuin;

دانلود رایگان متن کامل مقاله ISI 19 صفحه سال انتشار : 2015 سفارش ترجمه

Sirtuin 7 in cell proliferation, stress and disease: Rise of the Seventh Sirtuin!

Keywords: SIRT7; Sirtuin; Stress; Cancer; Hepatic lipid metabolism;

دانلود رایگان متن کامل مقاله ISI 25 صفحه سال انتشار : 2015 سفارش ترجمه

Identification of novel SIRT2-selective inhibitors using a click chemistry approach

Keywords: Sirtuin; Histone deacetylase; Inhibitor; Isozyme selectivity

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2014 سفارش ترجمه

Des-acyl ghrelin protects microvascular endothelial cells from oxidative stress-induced apoptosis through sirtuin 1 signaling pathway

Keywords: Des-G; des-acyl ghrelin; GHS-R; growth hormone-secretagogue receptor; SIRT; sirtuin; siRNA; small interfering ribonucleic acid; Ghrelin; Sirtuin; Manganese superoxide dismutase; Catalase;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2014 سفارش ترجمه