
LPS-mediated septic shock is augmented in ceramide synthase 2 null mice due to elevated activity of TNFα-converting enzyme
Keywords: BMDM, bone marrow derived macrophage; CerS2, ceramide synthase 2; LPS, lipopolysaccharide; SL, sphingolipid; TIMP3, tissue inhibitor of metalloproteinases 3; TNFα, tumor necrosis factor α; TACE, tumor necrosis factor α converting enzymeCeramide; Sphingoli