Keywords: arteriovenous malformation; pathogenic mutation; sensitivity; specificity; ACVRL1; Activin A receptor like kinase 1; AVM; Arteriovenous malformation; CI; Computerized tomography; ECHO; Echocardiography; ENG; Endoglin; GI; Gastrointestinal; HHT; Hereditary
مقالات ISI (ترجمه نشده)
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Keywords: Neuroendocrine Carcinoma; Neuroendocrine tumors; Cancer; Molecular; p53; Microsatellite Instability; APC; Adenomatous Polyposis Coli gene; ATM; Ataxia telangiectasia mutated gene; ATRX; Alpha-thalassemia mental retardation syndrome gene; CASP8; Caspase-8
Keywords: AGBL2; ATP/GTP binding protein-like 2; BMPR1A; Bone morphogenetic protein receptor, type 1A; CLEC3B; C-type lectin domain family 3; C1QTNF1; C1q and tumor necrosis factor related protein1; DDAH1; Dimethylarginine dimethylaminohydrolase 1; DEGs; Differenti
Keywords: Recurrent pericarditis; Pericarditis; Etiology; Diagnosis; Therapy; Prognosis; Cardiac magnetic resonance; Echocardiography; HSV; Herpes simplex virus; EBV; Ebstein Barr virus; HBV; Hepatitis B virus; HCV; Hepatitis C virus; HIV; Human immunodeficiency vi
Keywords: ACTB; β-actin, gene; ANP32B; Acidic leucine-rich nuclear phosphoprotein 32 family member B, gene; BLAST; Basic Local Alignment Search Tool; CCR1; Chemokine (C-C Motif) Receptor 1, gene; CEM; Conceptus Exposed Medium; CL; Corpus Luteum; Cy3; Cyanine 3; Cy
Keywords: Aryl hydrocarbon receptor; Transforming growth factor-β; Epithelial to mesenchymal transition; Smad4; Jun-activation domain binding protein; Lung cancer
Keywords: Kras; Myc; Smad4; Notch; IPMN; intraductal papillary mucinous neoplasm; MSI; microsatellite instability; PARP; poly-ADP-ribose polymerase; PDA; pancreatic ductal adenocarcinoma; PI3K; phosphoinositide 3-kinase inhibitor; TGF; transforming growth factor;
Keywords: ERCC1; excision repair cross-complementation group 1; NSCLC; non-small cell lung cancer; XRCC1; X-ray repair cross complementing group 1; CYP2A6; cytochrome P450 2A6; GSTM1; glutathione S-transferase mu1; CYP1A1; cytochrome P450 1A1; EGFR; epidermal growt
Keywords: ATRX; beta-catenin; DAXX; LEF1; p53; pancreatic ductal adenocarcinoma; pancreatic neuroendocrine tumor; Smad4; solid-pseudopapillary neoplasm; solitary fibrous tumor; STAT6
Keywords: Glaucoma; Trabecular meshwork; TGFβ signaling; Smad4; Wnt signaling; β-catenin; CrosstalkAH, Aqueous humor; CLANs, Cross-linked actin networks; Co-Smad, common mediator Smad; Dkk1, Dickkopf1; ECM, Extracellular matrix; GTM, Glaucomatous trabecular meshwor
MiR-183 promotes preadipocyte differentiation by suppressing Smad4 in goats
Keywords: PPARγ; peroxisome proliferator-activated receptor γ; C/EBPα; CCAAT/enhancer binding protein α; FAS; fatty acid synthase; TGFβ; transforming growth factor β; LRP6; low density lipoprotein receptor related protein 6; SREBP-1c; sterol regulatory elemen
Sumoylation of SMAD 4 ameliorates the oxidative stress-induced apoptosis in osteoblasts
Keywords: Apoptosis; Osteoblasts; Oxidative stress; SMAD4; SUMOylation;
Protein network module-based identification of key pharmacological pathways of Curcuma phaeocaulis Val. acting on hepatitis
Keywords: CP; Curcuma phaeocaulis Val.; ALT; Alanine aminotransferase; AST; Aspartate transaminase; LDH; Lactate dehydrogenase; PIN; Protein interaction network; HBV; Hepatitis B virus; HCV; Hepatitis C virus; TCM; Traditional Chinese medicine; PPIs; Protein-protei
The transcription factor SMAD4 and miR-10b contribute to E2 release and cell apoptosis in ovarian granulosa cells by targeting CYP19A1
Keywords: Pig; CYP19A1; SMAD4; miR-10b; E2; Granulosa cell apoptosis;
SMAD4 gene mutation predicts poor prognosis in patients undergoing resection for colorectal liver metastases
Keywords: Dorsophilia protein; Mothers against decapentaplegic homolog 4; Colorectal liver metastases; Colorectal cancer; Hepatectomy; KRAS; SMAD4; Dorsophilia protein, mothers against decapentaplegic homolog 4; CRC; colorectal cancer; CLM; colorectal liver metasta
Functional characteristics of a novel SMAD4 mutation from thoracic aortic aneurysms (TAA)
Keywords: AA; aortic aneurysm; TAA; thoracic aortic aneurysms; TGF-β; transforming growth factor β; R-Smads; receptor-regulated Smads; FBN1; fibrillin-1; TGFBR1; TGF-β receptor 1; TGFBR2; TGF-β receptor 2; TGFB2; transforming growth factor beta 2; TGFB3; transf
SMAD4 gene mutation increases the risk of aortic dilation in patients with hereditary haemorrhagic telangiectasia
Keywords: Hereditary haemorrhagic telangiectasia; SMAD4; Aortic dilatation; Computed tomography; TGF-β;
Original contributionSignificance of positive and inhibitory regulators in the TGF-β signaling pathway in colorectal cancers
Keywords: SMAD4; PPM1A; TGF-β1; Colorectal cancer; Prognosis; Tissue microarray; Immunohistochemistry;
Reduced Smad4 expression and DNA topoisomerase inhibitor chemosensitivity in non-small cell lung cancer
Keywords: Smad4; Lung cancer; TGFβ; DNA damage; Chemosensitivity;
MiR125b-5p protects endothelial cells from apoptosis under oxidative stress
Keywords: Human umbilical vein endothelial cells; Oxidative stress; miR125b-5p; SMAD4; Apoptosis;
LncRNA MALAT1 sponges miR-204 to promote osteoblast differentiation of human aortic valve interstitial cells through up-regulating Smad4
Keywords: lncRNAs; long non-coding RNAs; CAVD; calcific aortic valve disease; qRT-PCR; quantitative reverse transcription- polymerase chain reaction; VICs; valve interstitial cells; FBS; fetal bovine serum; AVR; aortic valve replacement; β-gal; β-galactosidase; 3
A Functional Variant of SMAD4 Enhances Thoracic Aortic Aneurysm and Dissection Risk through Promoting Smooth Muscle Cell Apoptosis and Proteoglycan Degradation
Keywords: TAAD; thoracic aortic aneurysm and dissection; SMCs; smooth muscle cells; AMD; aortic medial degeneration; TGF-β; transforming growth factor-β; MALDI-TOF MS; matrix-assisted laser desorption ionization time-of-flight mass spectrometry; SNP; single nucle
Smad4 is essential for directional progression from committed neural progenitor cells through neuronal differentiation in the postnatal mouse brain
Keywords: TGFβ/BMP signaling; Smad4; Subventricular zone; Neurogenesis; Neural stem cells; Neural progenitor cells;
CD147-induced cell proliferation is associated with Smad4 signal inhibition
Keywords: CD147; cluster of differentiation 147; PCa; prostate cancer; TGF-β; transforming growth factor-β; CD147-ICD; CD147 intracellular domain; FBS; fetal bovine serum; PFA; paraformaldehyde; PMSF; phenylmethanesulfonyl fluoride; CD147; p21WAF1; Smad4; Cancer;
Phosphatase PPM1A is a novel prognostic marker in pancreatic ductal adenocarcinoma
Keywords: Phosphatase; PPM1A; Pancreatic ductal adenocarcinoma; Prognosis, marker; Smad4; TGF-β; Immunohistochemistry;
Molecular pathogenesis of pancreatic ductal adenocarcinoma
Keywords: CDKN2A; driver genes; KRAS; pancreatic ductal adenocarcinoma; PanIN; SMAD4; TP53
Original ResearchThe role of S100a4 (Mts1) in Apc- and Smad4-driven tumour onset and progression
Keywords: S100a4; Colorectal cancer; Desmoids; Mts1; Apc; Smad4;
Overexpression of angiotensin II type 1 receptor in breast cancer cells induces epithelial-mesenchymal transition and promotes tumor growth and angiogenesis
Keywords: Breast cancer; AGTR1; EMT; Losartan; Smad4; Angiogenesis;
SMAD4 gene promoter mutations in patients with thyroid tumors
Keywords: Mutation; Promoter; SMAD4; Thyroid tumor;
Ancillary studies in EUS-FNA for solid pancreatic masses
Keywords: carcinoma; endosonography; EUS; fine needle aspiration; FISH; mesothelin; pancreas; SMAD4
Adenovirus encoding Smad4 suppresses glioma cell proliferation and increases apoptosis through cell cycle arrest at G1 phase
Keywords: Adenovirus; Smad4; Glioma cell; Proliferation;
Disruption of Smad4 in odontoblasts and dental epithelial cells influences the phenotype of multiple keratocystic odontogenic tumors
Keywords: Keratocystic odontogenic tumors; Knockout mouse; Smad4; Hh signaling pathway;
BMP-Smad4 signaling is required for precartilaginous mesenchymal condensation independent of Sox9 in the mouse
Keywords: BMP; Bmpr1a; Bmpr1b; Acvr1; Alk2; Alk3; Alk6; Smad4; Sox9; Cartilage; Mesenchymal condensation; Mouse;
Temporo-spatial requirement of Smad4 in dentin formation
Keywords: Smad4; Odontoblast; Maturation; Dentin formation; Mouse
ANXA1Ac2-26 peptide reduces ID1 expression in cervical carcinoma cultures
Keywords: [LaCit2]3; lanthanum citrate complex; μg; microgram; ACTB; beta-actin; ANX; annexin; ANXA1; annexin A1; BMP4; bone morphogenetic protein 4; BMPR1B; bone morphogenetic protein receptor, type IB; cDNA; complementary DNA; CO2; carbon dioxide; DNA; deoxyribo
Smad4 acts as tumor suppressor by antagonizing lymphangiogenesis in colorectal cancer
Keywords: Colorectal cancer; Smad4; Lymphangiogenesis; VEGF-C
Oocyte-derived Smad4 is not required for development of the oocyte or the preimplantation embryo
Keywords: Smad4; Oocyte; Embryo; Development
Tak1, Smad4 and Trim33 redundantly mediate TGF-β3 signaling during palate development
Keywords: TGF-β3 signaling; Palatogenesis; Tak1; Smad4; Trim33;
Pokemon (FBI-1) interacts with Smad4 to repress TGF-β-induced transcriptional responses
Keywords: Pokemon; Smad4; Interaction; TGF-β pathway;
The Smad3/Smad4/CDK9 complex promotes renal fibrosis in mice with unilateral ureteral obstruction
Keywords: CDK9 inhibitor; renal interstitial fibrosis; Smad3 phosphorylation; Smad4; TGF-β1; unilateral ureteral obstruction;
Expression and localization of Smad2 and Smad4 proteins in the porcine ovary
Keywords: Smad2; Smad4; Ovary; Pig;
Smad4 mediated BMP2 signal is essential for the regulation of GATA4 and Nkx2.5 by affecting the histone H3 acetylation in H9c2 cells
Keywords: Smad4; BMP2; Histone H3 acetylation; GATA4; Nkx2.5;
GATA-2 inhibits transforming growth factor-β signaling pathway through interaction with Smad4
Keywords: DMEM; Dulbecco's modified Eagle's medium; Epo; erythropoietin; FCS; fetal calf serum; GAPDH; glyceraldehyde-3-phosphate dehydrogenase; GFP; green fluorescent protein; HDAC3; histone deacetylase 3; siRNA; small interfering RNA; TGF-β; transforming growth
Nuclear expression of Smad proteins and its prognostic significance in clear cell renal cell carcinoma
Keywords: Smad3; Smad4; Clear cell renal cell carcinoma; Progression; Prognosis
The effect of TLR4/7 on the TGF-β-induced Smad signal transduction pathway in human keloid
Keywords: Keloid; Smad signal pathway; Toll-like receptor; Smad4; Smad7
Live-cell single-molecule imaging reveals clathrin and caveolin-1 dependent docking of SMAD4 at the cell membrane
Keywords: SMAD4; Membrane docking; Single-molecule fluorescence imaging; Clathrin; Caveolin-1
Inhibition of the Growth of Patient-Derived Pancreatic Cancer Xenografts with the MEK Inhibitor Trametinib Is Augmented by Combined Treatment with the Epidermal Growth Factor Receptor/HER2 Inhibitor Lapatinib
Keywords: EGFR; epidermal growth factor receptor; MRI; magnetic resonance imaging; RTKs; receptor tyrosine kinases; MAPKs; mitogen-activated protein kinases; SMAD4; SMAD family member 4 gene;
Association for Academic SurgeryGermline Mutations in SMAD4 Disrupt Bone Morphogenetic Protein Signaling
Keywords: juvenile polyposis; SMAD4; bone morphogenetic protein (BMP);
Immunolocalization of Smad4 protein in the testis of domestic fowl (Gallus domesticus) during postnatal development
Keywords: Smad4; Testis; Domestic fowl; TGFβ superfamily; Spermatogenesis
Concordant Promoter Methylation of Transforming Growth Factor-Beta Receptor Types I and II Occurs Early in Esophageal Squamous Cell Carcinoma
Keywords: TGFBR1; TGFBR2; Smad4; Methylation; Esophageal squamous cell carcinoma