Keywords: مهار کننده مولکولی کوچک; Lapatinib; Core–shell nanoparticles; Glioma; Small-molecule inhibitor; Drug delivery
مقالات ISI مهار کننده مولکولی کوچک (ترجمه نشده)
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The G2019S mutation in LRRK2 imparts resiliency to kinase inhibition
Keywords: مهار کننده مولکولی کوچک; Park8; Dardarin; Pharmacodynamics; Pharmacokinetics; Small-molecule inhibitor; LRRK2; Leucine-rich repeat kinase 2; PD; Parkinson disease; ATP; adenosine-tri phosphate; DTT; dithiothreitol; HSC70; Heat-shock cognate 70; Rab; Ras gene from rat brain, or Ra
Aberrant regulation of the Akt signaling network by human cytomegalovirus allows for targeting of infected monocytes
Keywords: مهار کننده مولکولی کوچک; Cytomegalovirus; Monocytes; Small-molecule inhibitor; HCMV; human cytomegalovirus; h; hour; EGF; epidermal growth factor; EGFR; EGF receptor; αvβ3; alpha v beta 3 integrin; gB; glycoprotein B; gH; glycoprotein H; PI3K; phosphoinositide 3-kinase; PTEN; p
Mcl-1 small-molecule inhibitors encapsulated into nanoparticles exhibit increased killing efficacy towards HCMV-infected monocytes
Keywords: مهار کننده مولکولی کوچک; Cytomegalovirus; Monocytes; Myeloid cell leukemia 1; Nanoparticles; Small-molecule inhibitor;
Novel aminotetrazole derivatives as selective STAT3 non-peptide inhibitors
Keywords: مهار کننده مولکولی کوچک; STAT3; Small-molecule inhibitor; Aminotetrazole; Anticancer drug; Inflammation; STAT; signal transducer and activation of transcription; SH2; Src Homoly 2; Th; T helper; OSM; oncostatin M; MTT; 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide;
Beating the odds: BETs in disease
Keywords: مهار کننده مولکولی کوچک; BETs; transcription; cancer; inflammation; viral infection; small-molecule inhibitor
Small-molecule inhibitors of the Myc oncoprotein
Keywords: مهار کننده مولکولی کوچک; Myc; Max; Protein-protein interaction; Small-molecule inhibitor; Cancer; Transcription factor;
Design, synthesis and biological evaluation of Pontin ATPase inhibitors through a molecular docking approach
Keywords: مهار کننده مولکولی کوچک; ATPase activity; Pontin; Molecular docking; Small-molecule inhibitor; Enzymatic assay;
Inhibition of Axl improves the targeted therapy against ALK-mutated neuroblastoma
Keywords: مهار کننده مولکولی کوچک; Neuroblastoma; ALK; Targeted therapy; Axl; Small-molecule inhibitor;
Randomized Phase II Trial of the Cyclin-Dependent Kinase Inhibitor Dinaciclib (MK-7965) Versus Capecitabine in Patients With Advanced Breast Cancer
Keywords: مهار کننده مولکولی کوچک; Efficacy; Monotherapy; Safety; Small-molecule inhibitor; Solid tumors;
A substrate-optimized electrophoretic mobility shift assay for ADAM12
Keywords: مهار کننده مولکولی کوچک; Metalloprotease; ADAM12; Fluorimetric assay; Mobility shift assay; Small-molecule inhibitor; Peptide array
Validation of a cell-based ELISA as a screening tool identifying anti-alphavirus small-molecule inhibitors
Keywords: مهار کننده مولکولی کوچک; BSA; bovine serum albumin; CHIKV; Chikungunya virus; CPE; cytopathic effect; EEEV; eastern equine encephalitis virus; ELISA; enzyme-linked immunosorbent assay; HRP; horseradish peroxidase; IC50; 50% inhibitory concentration; MAb; monoclonal antibody; MOI;
Sophoraflavanone G induces apoptosis of human cancer cells by targeting upstream signals of STATs
Keywords: مهار کننده مولکولی کوچک; Apoptosis; Cancer; Small-molecule inhibitor; Sophoraflavanone G; STATs;
A thienopyrimidine derivative induces growth inhibition and apoptosis in human cancer cell lines via inhibiting Aurora B kinase activity
Keywords: مهار کننده مولکولی کوچک; Aurora B; Small-molecule inhibitor; Molecular modeling; ATP-competitive; Growth inhibition; ApoptosisHTS, high throughput screening; IC50, inhibitory concentration (50%); PhH3 (Ser 10), phospho-histone H3 (Ser 10); PhAurB (Thr232), phospho-Aurora B (Thr23
ApoG2 as the most potent gossypol derivatives inhibits cell growth and induces apoptosis on gastric cancer cells
Keywords: مهار کننده مولکولی کوچک; ApoG2; Small-molecule inhibitor; Gastric cancer
Small molecule inhibition of fibroblast growth factor receptors in cancer
Keywords: مهار کننده مولکولی کوچک; Fibroblast growth factor receptor; Cancer; Small-molecule inhibitor; Structure–activity relationship; Cancer chemotherapy
Cysteine cathepsins: From structure, function and regulation to new frontiers
Keywords: مهار کننده مولکولی کوچک; Cysteine cathepsin; Protein inhibitor; Cystatin; Small-molecule inhibitor; Mechanism of interaction; Biological function;
Development of a sphingosine kinase 1 specific small-molecule inhibitor
Keywords: مهار کننده مولکولی کوچک; Sphingosine kinase; Sphingosine; Sphingosine-1-phosphate; Small-molecule inhibitor; Hyperproliferative disease; Inflammatory disease
Glucose metabolism activation by SHIP2 inhibitors via up-regulation of GLUT1 gene in L6 myotubes
Keywords: مهار کننده مولکولی کوچک; SHIP2 (SH2 domain-containing inositol 5′-phosphatase 2); AS1938909 (3-[(2,4-dichlorobenzyl)oxy]-N-(2,6-difluorobenzyl)thiophene-2-carboxamide); AS1949490 (3-[(4-chlorobenzyl)oxy]-N-[(1S)-1-phenylethyl]-2-thiophenecarboxamide); Small-molecule inhibitor; In
Compensatory activation of Akt in response to mTOR and Raf inhibitors – A rationale for dual-targeted therapy approaches in neuroendocrine tumor disease
Keywords: مهار کننده مولکولی کوچک; Neuroendocrine tumors; Small-molecule inhibitor; Ras–Raf–MEK–Erk1/2 signaling; PI(3)K–Akt–mTOR signaling; Apoptosis; G0/G1 arrest
A novel small-molecule disrupts Stat3 SH2 domain–phosphotyrosine interactions and Stat3-dependent tumor processes
Keywords: مهار کننده مولکولی کوچک; Stat3; S3I-201; S3I-201.1066; Small-molecule inhibitor; Antitumor effects; Antitumor cell effects
A selective small-molecule inhibitor of c-Jun N-terminal kinase 1
Keywords: مهار کننده مولکولی کوچک; JNK, c-Jun N-terminal kinase; MEF, mouse embryonic fibroblast; UVB, ultraviolet BAV-7; Small-molecule inhibitor; c-Jun N-terminal kinase inhibitor; c-Jun phosphorylation; Sub-G1 accumulation
Identification and characterization of small-molecule inhibitors of Tie2 kinase
Keywords: مهار کننده مولکولی کوچک; Tie2; Small-molecule inhibitor; Solubility; Stability; CYP450, selectivity; Angiogenesis; Choroidal neovascularization
Receptor tyrosine kinase inhibitors in thyroid cancer
Keywords: مهار کننده مولکولی کوچک; kinase; thyroid; monoclonal antibody; small-molecule inhibitor