Discovery of pyrazoles as novel FPR1 antagonists
Keywords: مولکول های کوچک; FPR1 antagonist; Hit-to-lead; Small molecule
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Hippocampal and cortical neuronal growth mediated by the small molecule natural product clovanemagnolol
Keywords: مولکول های کوچک; Natural products; Clovanemagnolol; Growth factors; Neuronal; Cortical; Hippocampal; Small molecule; Synthesis
Contact printing of the emitting layer for high performance multilayered phosphorescent organic light-emitting diodes
Keywords: مولکول های کوچک; Organic light-emitting diodes; Contact printing; Small molecule; Multilayer; Solution process
Tetrabutyl-tetraphenyl-diindenoperylene derivatives as alternative green donor in bulk heterojunction organic solar cells
Keywords: مولکول های کوچک; Green donor; Solar cell; Organic; Small molecule; Morphology
Effect of concentration gradients in ZnPc:C60 bulk heterojunction organic solar cells
Keywords: مولکول های کوچک; Graded heterojunction; Small molecule; Interface recombination; Open-circuit voltage; Drift-diffusion model; External quantum efficiency
The role of energy level matching in organic solar cells—Hexaazatriphenylene hexacarbonitrile as transparent electron transport material
Keywords: مولکول های کوچک; Solar cell; Organic; Small molecule; HATCN; Electron transport; Doping
A novel small molecule fluorescent sensor for Zn2+ based on pyridine-pyridone scaffold
Keywords: مولکول های کوچک; Zn2+; Fluorescent sensor; Pyridine-pyridone; Small molecule; Water-soluble;
Isolation of a small molecule with anti-MRSA activity from a mangrove symbiont Streptomyces sp. PVRK-1 and its biomedical studies in Zebrafish embryos
Keywords: مولکول های کوچک; Methicillin resistant; Staphylococcus aureus; Small molecule; Mangrove; RP-HPLC; Streptomyces; Cardiac assay; Organogenesis; Biochemial study; Zebrafish embryo; Minimal inhibitory concentration;
Discovery of small molecule human FPR1 receptor antagonists
Keywords: مولکول های کوچک; FPR1 antagonist; Hit-to-lead; Small molecule
A negative allosteric modulator demonstrates biased antagonism of the follicle stimulating hormone receptor
Keywords: مولکول های کوچک; Follicle stimulating hormone; Receptor; Small molecule
Ultra trace analysis of small molecule by label-free impedimetric immunosensor using multilayer modified electrode
Keywords: مولکول های کوچک; Label-free; Trace analysis; Small molecule; Chloramphenicol; Impedance biosensor; Sensitivity enhancement
Novel symmetric squaraine chromophore containing triphenylamine for solution processed small molecule bulk heterojunction solar cells
Keywords: مولکول های کوچک; Bulk heterojunction solar cell; Small molecule; Squaraine; Molecular engineering
Label-free capacitive immunosensors for ultra-trace detection based on the increase of immobilized antibodies on silver nanoparticles
Keywords: مولکول های کوچک; Capacitance; Label-free biosensor; Small molecule; Macromolecule; Nano material; High sensitivity
Cardiac HDAC6 catalytic activity is induced in response to chronic hypertension
Keywords: مولکول های کوچک; Histone deacetylase; Hypertension; Heart failure; Cardiac hypertrophy; Small molecule
Molecular engineering of Diketopyrrolopyrrole-based photosensitizer for solution processed small molecule bulk heterojunction solar cells
Keywords: مولکول های کوچک; Bulk heterojunction solar cell; Small molecule; Molecular engineering
Water and oxygen induced degradation of small molecule organic solar cells
Keywords: مولکول های کوچک; Photovoltaic; Degradation; Water; Oxygen; TOF-SIMS; Small molecule
The small molecule harmine regulates NFATc1 and Id2 expression in osteoclast progenitor cells
Keywords: مولکول های کوچک; DYRK1A; Harmine; Id2; NFATc1; Osteoclast; Small molecule;
A monolithically integrated organic photodetector and thin film transistor
Keywords: مولکول های کوچک; Small molecule; Photodetector; Thin film transistor; Integration
A novel small-molecule inhibitor of IL-6 signalling
Keywords: مولکول های کوچک; Small molecule; IL-6 signalling; Inhibitor; STAT3
Development of novel inhibitors targeting HIF-1α towards anticancer drug discovery
Keywords: مولکول های کوچک; Hypoxia; HIF-1α; Small molecule; Anticancer; Antiproliferative; Drug discovery; Pyridylpyrimidine
A carbon nanotubes based ATP apta-sensing platform and its application in cellular assay
Keywords: مولکول های کوچک; Fluorescent aptasensor; SWNTs; ATP detection; Small molecule; Cellular assay
Synthesis of 7-benzyl-5-(piperidin-1-yl)-6,7,8,9-tetrahydro-3H-pyrazolo[3,4-c][2,7]naphthyridin-1-ylamine and its analogs as bombesin receptor subtype-3 agonists
Keywords: مولکول های کوچک; Bombesin receptor subtype-3; Agonists; Small molecule
Insulin-releasing and metabolic effects of small molecule GLP-1 receptor agonist 6,7-dichloro-2-methylsulfonyl-3-N-tert-butylaminoquinoxaline
Keywords: مولکول های کوچک; Glucagon-like peptide-1 (GLP-1); Glucose homeostasis; Small molecule; Insulin secretion; Diabetes
Combination of small molecules enhances differentiation of mouse embryonic stem cells into intermediate mesoderm through BMP7-positive cells
Keywords: مولکول های کوچک; Mouse embryonic stem cell; Small molecule; BMP7; Intermediate mesoderm
Development of a high-throughput screening assay for cytoprotective agents in rotenone-induced cell death
Keywords: مولکول های کوچک; Rotenone; High-throughput screening; High-content analysis; Small molecule; Parkinson’s disease; Carnosic acid
Identification of small molecule inhibitors of telomerase activity through transcriptional regulation of hTERT and calcium induction pathway in human lung adenocarcinoma A549 cells
Keywords: مولکول های کوچک; Small molecule; Telomerase activity; hTERT; hTERT promoter; Anchorage-independent growth; Calcium release
2-(3,4-Dihydro-2H-pyrrolium-1-yl)-3oxoindan-1-olate (DHPO), a novel, synthetic small molecule that alleviates insulin resistance and lipid abnormalities
Keywords: مولکول های کوچک; Diabetes; Small molecule; Lipid; AMP-activated protein kinase
Production and characterization of a genetically engineered anti-caffeine camelid antibody and its use in immunoaffinity chromatography
Keywords: مولکول های کوچک; Caffeine; Camelid antibody; CDR grafting; Immunoaffinity chromatography; Small molecule; VHH
Multicentric parallel phase II trial of the polo-like kinase 1 inhibitor BI 2536 in patients with advanced head and neck cancer, breast cancer, ovarian cancer, soft tissue sarcoma and melanoma. The first protocol of the European Organization for Research
Keywords: مولکول های کوچک; Phase II trial; Polo-like kinase inhibitor; PLK; BI 2536; Small molecule; Head and neck cancer; Breast cancer; Ovarian cancer; Soft tissue sarcoma; Melanoma
Small molecule modulation of HH-GLI signaling: Current leads, trials and tribulations
Keywords: مولکول های کوچک; Hedgehog; GLI; Smoothened; Cancer; Small molecule
Advances in biosensor-based analysis for antimicrobial residues in foods
Keywords: مولکول های کوچک; Antibiotic; Antimicrobial residue; Biosensor; Contaminant; Detection; Food; Food contaminant; Multiplexing; Small molecule; Surface-plasmon resonance
Neutralizing endogenous chemokines with small molecules
Keywords: مولکول های کوچک; BSA; Bovine serum albumin; DARC; Duffy antigen receptor for chemokines; GAG; Glycosaminoglycans; GPCR; G-protein-coupled receptor; IL; Interleukin; LPS; Lipopolysaccharide; MS; Multiple sclerosis; Chemokines; Cytokines; GPCRs; Decoy receptors; Neutralizin
Discovery of non-peptidergic MrgX1 and MrgX2 receptor agonists and exploration of an initial SAR using solid-phase synthesis
Keywords: مولکول های کوچک; Mas related; MrgX1; MrgX2; Agonist; SNSR; Sensory-neuron specific receptors; Nociception; Non-peptidergic; Small molecule; Solid-phase; R-SAT
Potent agonists of the Hedgehog signaling pathway
Keywords: مولکول های کوچک; Hedgehog signaling pathway; Agonist; SAR study; Small molecule;
Organic thin-film solar cell employing a novel electron-donor material
Keywords: مولکول های کوچک; Organic photovoltaic cell; Heterojunction; Small molecule; Tetraphenyldibenzoperiflanthene
Bulk heterojunction organic photovoltaic devices based on low band gap small molecule BTD-TNP and perylene–anthracene diimide
Keywords: مولکول های کوچک; Organic photovoltaic device; Bulk heterojunction; Small molecule; Benzothiadiazole; Perylene diimide
Increased plasma membrane expression of human follicle-stimulating hormone receptor by a small molecule thienopyr(im)idine
Keywords: مولکول های کوچک; FSH receptor; Pharmacoperone; Peptidomimetic; Small molecule; GPCR; Receptor; Therapeutics;
Novel thienopyrimidine and thiazolopyrimidine kinase inhibitors with activity against Tie-2 in vitro and in vivo
Keywords: مولکول های کوچک; Kinase; Tie-2; TEK; Inhibition; Angiogenesis; Small molecule
Discovery of small molecule human C5a receptor antagonists
Keywords: مولکول های کوچک; C5a antagonist; Inverse agonists; Small molecule; Ugi multicomponent
Identification of small molecule inhibitors of proline-rich tyrosine kinase 2 (Pyk2) with osteogenic activity in osteoblast cells
Keywords: مولکول های کوچک; Pyk2; Kinase; Small molecule; Chemical screen; Molecular model; Osteoblast; Bone
Identification of a small molecule SIRT2 inhibitor with selective tumor cytotoxicity
Keywords: مولکول های کوچک; Sirtuins; SIRT2; Inhibitor; Cancer; Small molecule; AC-93253;
Design and synthesis of a simplified inhibitor for XIAP-BIR3 domain
Keywords: مولکول های کوچک; XIAP-BIR3 domain; Molecular simplification; Small molecule
Inhibition of human immunodeficiency virus type 1 (HIV-1) nuclear import via Vpr-Importin α interactions as a novel HIV-1 therapy
Keywords: مولکول های کوچک; HIV-1 inhibitor; Vpr; Nuclear import inhibition; Importin α; Small molecule; Macrophage;
5,6-Dihydro-1H-pyridin-2-ones as potent inhibitors of HCV NS5B polymerase
Keywords: مولکول های کوچک; Hepatitis C virus (HCV); NS5B polymerase; Small molecule; Non-nucleoside NS5B inhibitor; 5,6-Dihydro-1H-pyridin-2-ones
Selective and direct activation of human neutrophils but not eosinophils by Toll-like receptor 8
Keywords: مولکول های کوچک; Toll-like receptor; immunostimulatory RNA; neutrophil; granulocyte; immunotherapy; small molecule; 3M001; 3M002; 3M007; R-848CD62L, CD62 ligand; fMLP, Formyl-Met-Leu-Phe; FSC, Forward scatter; HBSS, Hank's balanced salt solution; isRNA, Immunostimulatory
Tumor-specific induction of apoptosis by a p53-reactivating compound
Keywords: مولکول های کوچک; HDF, Human Diploid Fibroblasts; ELISA, Enzyme-Linked Immunosorbent Assay; FACS, Fluorescence-activated cell sorter; TUNEL, Terminal deoxynucleotidyl Transferase Biotin-dUTP Nick End Labelingp53-reactivation; Apoptosis; Small molecule; MDM2; Cancer
Investigation of surface plasmon resonance biosensor for skin sensitizers studies
Keywords: مولکول های کوچک; Allergens; Biosensor; Skin sensitization; Small molecule; Surface plasmon resonance
Rational design of the first small-molecule antagonists of NHERF1/EBP50 PDZ domains
Keywords: مولکول های کوچک; NHERF1; EBP50; PDZ domain; Protein–protein interaction inhibitor; Indole; Small molecule
Achieving multi-isoform PI3K inhibition in a series of substituted 3,4-dihydro-2H-benzo[1,4]oxazines
Keywords: مولکول های کوچک; Kinase; PI3K; Inflammation; Small molecule; Isoform
Novel HCV NS5B polymerase inhibitors derived from 4-(1′,1′-dioxo-1′,4′-dihydro-1′λ6-benzo[1′,2′,4′]thiadiazin-3′-yl)-5-hydroxy-2H-pyridazin-3-ones. Part 2: Variation of the 2- and 6-pyridazinone substituents
Keywords: مولکول های کوچک; Pyridazinones; 5-Hydroxy-3(2H)-pyridazinone derivatives; Hepatitis C virus (HCV); Structure-based design; RNA-dependent RNA polymerase (RdRp); Small molecule; Non-nucleoside NS5B inhibitors