Keywords: مهار کننده مولکول کوچک; Androgen receptor; Prostate cancer; Dimerization; Small molecule inhibitor;
مقالات ISI مهار کننده مولکول کوچک (ترجمه نشده)
مقالات زیر هنوز به فارسی ترجمه نشده اند.
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در صورتی که به ترجمه آماده هر یک از مقالات زیر نیاز داشته باشید، می توانید سفارش دهید تا مترجمان با تجربه این مجموعه در اسرع وقت آن را برای شما ترجمه نمایند.
Keywords: مهار کننده مولکول کوچک; A2Ms; α-2- macroglobulins; AFLEI; elastase inhibitor from Aspergillus flavus; AFUEI; elastase inhibitor from Aspergillus fumigatus; AP; α-2-antiplasmin; AT; antithrombin; bFGF; basic fibroblast growth factor; BSuPI; Bacillus subtilis protease inhibitor;
Functional recombinant human Legumain protein expression in Pichia pastoris to enable screening for Legumain small molecule inhibitors
Keywords: مهار کننده مولکول کوچک; Legumain; Pichia pastoris; Enzyme activity; Small molecule inhibitor;
Dual requirement for STAT signaling in dendritic cell immunobiology
Keywords: مهار کننده مولکول کوچک; APC; antigen presenting cells; CSFE; carboxyfluorescein diacetate succinimidyl ester; DC; dendritic cells; FBS; fetal bovin serum; iDC; immature DC; LPS; lipopolysaccharide; mDC; mature DC; MLR; mixed leucocyte reaction; mAb; monoclonal antibodies; PBMC;
Discovery and characterization of selective small molecule inhibitors of the mammalian mitochondrial division dynamin, DRP1
Keywords: مهار کننده مولکول کوچک; DRP1; Mitochondria; Small molecule inhibitor; Fission; Dynamics;
Targeting Heat Shock Protein 70 as an antiviral strategy against grass carp reovirus infection
Keywords: مهار کننده مولکول کوچک; Heat Shock Protein 70; Grass carp reovirus; Small molecule inhibitor; Antiviral target; Antiviral therapy;
Phytochemicals as inhibitors of NF-κB for treatment of Alzheimer's disease
Keywords: مهار کننده مولکول کوچک; AChE; acetylcholine esterase; AD; Alzheimer's disease; AP1; activator protein 1; APP; amyloid precursor protein; Aβ; amyloid beta; BACE1; β-site of APP cleaving enzyme; Bax; Bcl-2-associated X protein; BBB; blood-brain barrier; Bcl-2; B-cell lymphoma
Targeting CD40-Induced TRAF6 Signaling in Macrophages Reduces Atherosclerosis
Keywords: مهار کننده مولکول کوچک; atherosclerosis; drug development; immunology; inflammation; nanotechnology; Apoe; apolipoprotein E; BMDM; bone marrow-derived macrophage; CVD; cardiovascular disease; DC; dendritic cell; NF-κB; nuclear factor kappa-light-chain-enhancer of activated B ce
Discovery of pyrazolo[1,5-a]pyrimidine-3-carbonitrile derivatives as a new class of histone lysine demethylase 4D (KDM4D) inhibitors
Keywords: مهار کننده مولکول کوچک; KDM4D; Histone lysine demethylase; Epigenetics; Small molecule inhibitor; Structure-activity relationship;
Novel small molecule guanidine Sigma1 inhibitors for advanced prostate cancer
Keywords: مهار کننده مولکول کوچک; AWZXAAFPWAXAOV-UHFFFAOYSA-N; VCKYUMDZRLPKLV-UHFFFAOYSA-N; PUUYAOSAGFBJKV-UHFFFAOYSA-N; DOFFSRGAEKCJAF-UHFFFAOYSA-N; JABKQQAOOJHXSC-LCWMZCLWSA-N; Sigma1; Sigma-1 receptor; Sigma-1 chaperone; Prostate cancer; Guanidine; Small molecule inhibitor;
Discovery of N-substituted 7-azaindoles as Pan-PIM kinase inhibitors - Lead series identification - Part II
Keywords: مهار کننده مولکول کوچک; Pan-PIM kinases; X-ray crystallography; AML; PK/PD; Hit-to-Lead; Small molecule inhibitor; Cancer;
Strong synergism between small molecule inhibitors of HER2, PI3K, mTOR and Bcl-2 in human breast cancer cells
Keywords: مهار کننده مولکول کوچک; Small molecule inhibitor; Synergism; Triple-negative cancer;
Identification of novel small molecule inhibitors against NS2B/NS3 serine protease from Zika virus
Keywords: مهار کننده مولکول کوچک; Zika flavivirus; NS2B/NS3 serine protease; Small molecule inhibitor; apo ZIKV NS2B-NS3pro structure; ZIKV; Zika flavivirus; HCV; hepatitis C virus; DENV; Dengue virus; WNV; West Nile virus; SPR; surface plasmon resonance; HTS; high-throughput screening;
Original ArticleAnti-myeloma effects of ruxolitinib combined with bortezomib and lenalidomide: A rationale for JAK/STAT pathway inhibition in myeloma patients
Keywords: مهار کننده مولکول کوچک; Multiple myeloma; JAK/STAT; Ruxolitinib; JAK1; JAK2; Small molecule inhibitor;
Novel BCL2 inhibitor, Disarib induces apoptosis by disruption of BCL2-BAK interaction
Keywords: مهار کننده مولکول کوچک; Small molecule inhibitor; Apoptosis; Cancer therapeutics; Cell death; Chemotherapy; BAK;
Discovery of small molecule inhibitors for the C. elegans caspase CED-3 by high-throughput screening
Keywords: مهار کننده مولکول کوچک; C. elegans; Caspase; CED-3; High-throughput screening; Small molecule inhibitor; Apoptosis;
A Small Molecule Inhibitor of the β-Catenin-TCF4 Interaction Suppresses Colorectal Cancer Growth In Vitro and In Vivo
Keywords: مهار کننده مولکول کوچک; Colorectal cancer; β-catenin; HI-B1; Small molecule inhibitor; Patient-derived xenograft; Precision medicine;
An overview of the binding models of FGFR tyrosine kinases in complex with small molecule inhibitors
Keywords: مهار کننده مولکول کوچک; FGFR; Small molecule inhibitor; Crystal structure; DFG-in/out; Irreversible; Pharmacological activity;
Discovery of KDM5A inhibitors: Homology modeling, virtual screening and structure–activity relationship analysis
Keywords: مهار کننده مولکول کوچک; KDM5A; Histone lysine demethylation; Structure–activity relationship; Epigenetics; Small molecule inhibitor
ESI-IMS-MS: A method for rapid analysis of protein aggregation and its inhibition by small molecules
Keywords: مهار کننده مولکول کوچک; Aβ; amyloid-β peptide; Aβ40; amyloid-β peptide residues 1-40; AD; Alzheimer's disease; ADH; alcohol dehydrogenase; AFM; atomic force microscopy; CCS; collision-cross sectional area; Cl-NQTrp; chloronaphthoquinine-tryptophan; CsI; caesium iodide; D
BET bromodomain inhibition promotes neurogenesis while inhibiting gliogenesis in neural progenitor cells
Keywords: مهار کننده مولکول کوچک; Neurogenesis; Gliogenesis; Neural progenitor cells; BET bromodomain; Small molecule inhibitor; I-BET; JQ-1; Epigenetics
A novel inhibitor of BCL2, Disarib abrogates tumor growth while sparing platelets, by activating intrinsic pathway of apoptosis
Keywords: مهار کننده مولکول کوچک; Small molecule inhibitor; Apoptosis; Cancer therapeutics; Cell death; Chemotherapy;
Design, synthesis and biological evaluation of pyrido[2,3-d]pyrimidin-7-(8H)-ones as HCV inhibitors
Keywords: مهار کننده مولکول کوچک; Hepatitis C; HCV genotype 1b replicon; Small molecule inhibitor; Pyrido[2,3-d]pyrimidin-7-(8H)-ones; BOP; (Benzotriazol-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; m-CPBA; 3-Chloroperbenzoic acid; DBU; 1,8-Diazabicyclo[5.4.0]undec-7-ene; D
Small molecule therapeutics targeting F-box proteins in cancer
Keywords: مهار کننده مولکول کوچک; Ubiquitin; E3 ligase; F-box protein; Small molecule inhibitor; Cancer;
An inducible heat shock protein 70 small molecule inhibitor demonstrates anti-dengue virus activity, validating Hsp70 as a host antiviral target
Keywords: مهار کننده مولکول کوچک; Heat shock protein 70; Dengue virus; Small molecule inhibitor; Antiviral target; Antiviral therapy;
Identification, synthesis and pharmacological evaluation of novel anti-EV71 agents via cyclophilin A inhibition
Keywords: مهار کننده مولکول کوچک; Cyclophilin A; EV71; HFMD; Small molecule inhibitor;
Identification of 3,5,6-substituted indolin-2-one’s inhibitors of Aurora B by development of a luminescent kinase assay
Keywords: مهار کننده مولکول کوچک; Aurora B; Small molecule inhibitor; Luminescent kinase assay; Indolin-2-one
Identification of a lead like inhibitor of the hepatitis C virus non-structural NS2 autoprotease
Keywords: مهار کننده مولکول کوچک; Hepatitis C virus; NS2; Small molecule inhibitor; Autoprotease; HCV; Hepatitis C virus; NS; non-structural; SGR; subgenomic replicon; DAA; direct acting antiviral; JFH1; Japanese Fulminant Hepatitis 1; EC50; 50% effective concentration; LarI; luciferase a
Discovery of potent 1H-imidazo[4,5-b]pyridine-based c-Met kinase inhibitors via mechanism-directed structural optimization
Keywords: مهار کننده مولکول کوچک; c-Met tyrosine kinase; Small molecule inhibitor; Imidazonaphthyridinone; Imidazopyridine; Binding mode; Pyridone-3-carboxamide; Cyclopropane-1,1-dicarboxamide
Structural and sequential context of p53: A review of experimental and theoretical evidence
Keywords: مهار کننده مولکول کوچک; p53; Mutation; Thermodynamic; Molecular dynamics simulation; Small molecule inhibitor;
Discovery and structure-activity analysis of 4-((5-nitropyrimidin-4-yl)amino)benzimidamide derivatives as novel protein arginine methyltransferase 1 (PRMT1) inhibitors
Keywords: مهار کننده مولکول کوچک; PRMT1; Small molecule inhibitor; Epigenetics; Structure-activity relationship; Protein arginine methyltransferase;
Substituted piperidines as HDM2 inhibitors
Keywords: مهار کننده مولکول کوچک; HDM2; MDM2; p53; Substituted piperidine; Small molecule inhibitor; Cancer; Oncology;
Design, synthesis and bioevaluation of N-trisubstituted pyrimidine derivatives as potent aurora A kinase inhibitors
Keywords: مهار کننده مولکول کوچک; Pyrimidine derivative; Small molecule inhibitor; Antitumor; Aurora A kinase; Synthesis
3-Hydroxypyrrolidine and (3,4)-dihydroxypyrrolidine derivatives: Inhibition of rat intestinal α-glucosidase
Keywords: مهار کننده مولکول کوچک; 1-Benzyl-3-hydroxypyrrolidine; 1-Benzyl-3,4-dihydroxypyrrolidine; Small molecule inhibitor; α-Glucosidase; Rat intestinal cells
4-Amino-2-arylamino-6-(2,6-dichlorophenyl)-pyrido[2,3-d]pyrimidin-7-(8H)-ones as BCR kinase inhibitors for B lymphoid malignancies
Keywords: مهار کننده مولکول کوچک; Non-Hodgkin's lymphomas; B-cell receptor; Kinases; Small molecule inhibitor; 7-oxopyrido[2,3-d]pyrimidinesAbl, Abelson; Bcl-2, B-cell lymphoma 2; BCR, B-cell receptor; Btk, Bruton's tyrosine kinase; CLL, chronic lymphocytic leukemia; DLBCL, diffuse large
Prevention of BMS-777607-induced polyploidy/senescence by mTOR inhibitor AZD8055 sensitizes breast cancer cells to cytotoxic chemotherapeutics
Keywords: مهار کننده مولکول کوچک; Breast cancer; Receptor tyrosine kinase; Small molecule inhibitor; Senescence; Polyploidy; mTOR signaling; Chemosensitivity; AXL; Greek word anexelekto; BCR; breakpoint cluster region; BRAF; B-Rapidly Accelerated Fibrosarcoma; DAPI; 4â²,6â²-diamidino-2-
NFAT as cancer target: Mission possible?
Keywords: مهار کننده مولکول کوچک; ADP; adenosine di-phosphate; AICD; activation-induced cell death; AKAP79; A-kinase anchor protein 79; Ang-2; angiopoietin-2; AP1; activator protein 1; ARRE-2; antigen receptor response element-2; BMP4; bone morphogenetic protein 4; CABIN1; calcineurin-bin
Menadione and ethacrynic acid inhibit the hypoxia-inducible factor (HIF) pathway by disrupting HIF-1α interaction with p300
Keywords: مهار کننده مولکول کوچک; Hypoxia inducible factor-1α; p300; Small molecule inhibitor; Menadione; Ethacrynic acid;
Five-membered iminocyclitol α-glucosidase inhibitors: Synthetic, biological screening and in silico studies
Keywords: مهار کننده مولکول کوچک; Iminocyclitol; Small molecule inhibitor; α-Glucosidase; Enantiopure compound; (3,4)-Dihydroxypyrrolidine;
Combined inhibition of the phosphoinosityl-3-kinase (PI3Kinase) P110δ subunit and mitogen-extracellular activated protein kinase (MEKinase) shows synergistic cytotoxicity against human acute myeloid leukemia progenitors
Keywords: مهار کننده مولکول کوچک; AML; Targeted therapy; p110δ; MEK1/MEK2; Small molecule inhibitor; PCN5603; U0126; Drug combination;
Evaluation of adamantane hydroxamates as botulinum neurotoxin inhibitors: Synthesis, crystallography, modeling, kinetic and cellular based studies
Keywords: مهار کننده مولکول کوچک; Botulinum neurotoxin; Protease inhibitor; Adamantane derivatives; Small molecule inhibitor; Zinc-dependent metalloprotease
ACK1 tyrosine kinase: Targeted inhibition to block cancer cell proliferation
Keywords: مهار کننده مولکول کوچک; ACK1; TNK2; AKT; Tyrosine kinase; Small molecule inhibitor; Drug resistance
Novel soluble myeloid cell leukemia sequence 1 (Mcl-1) inhibitor (E,E)-2-(benzylaminocarbonyl)-3-styrylacrylonitrile (4g) developed using a fragment-based approach
Keywords: مهار کننده مولکول کوچک; Mcl-1; Small molecule inhibitor; Fragment-based approach; AnticancerBcl-2, B-cell lymphoma 2; Mcl-1, myeloid cell leukemia sequence 1; Bcl-xL, B-cell lymphoma x long; Bax, Bcl-2-associated x protein; Bak, Bcl-2 homologous antagonist/killer; BH3, Bcl-2 hom
Selective Inhibitors of Nuclear Export Block Pancreatic Cancer Cell Proliferation and Reduce Tumor Growth in Mice
Keywords: مهار کننده مولکول کوچک; Exportin; Translocation; Nucleus; Small Molecule Inhibitor; CRM1CRM-1, chromosome region maintenance 1; FITC, fluorescein isothiocyanate; HPDE, human pancreatic ductal epithelial; IC50, median inhibitory concentration; LMB, leptomycin B; MTT, 3-(4,5-dimet
Synthesis and structure–activity relationship studies of 1,3-disubstituted 2-propanols as BACE-1 inhibitors
Keywords: مهار کننده مولکول کوچک; AD, Alzheimer’s disease; Aβ, amyloid β; APP, amyloid precursor protein; HEA, hydroxyethylamines; BACE-1, β-secretaseBACE-1; β-Secretase; 1,3-Disubstituted 2-propanol; Small molecule inhibitor; Blood–brain barrier; Cathepsin D; HEA; Hydroxyethylamines
8-Alkylthio-6-thio-substituted theophylline analogues as selective noncompetitive progesterone receptor antagonists
Keywords: مهار کننده مولکول کوچک; AlkP, alkaline phosphatase; AR, androgen receptor; ER, estrogen receptor; GR, glucocorticoid receptor; LBD, ligand binding domain; PR, progesterone receptor; SAR, structure activity relationshipProgesterone; Steroid receptor; Small molecule inhibitor; The
Discovery of novel benzylidene-1,3-thiazolidine-2,4-diones as potent and selective inhibitors of the PIM-1, PIM-2, and PIM-3 protein kinases
Keywords: مهار کننده مولکول کوچک; PIM kinases; Hit-to-lead; Small molecule inhibitor; Thiazolidine-2,4-dione; X-ray crystallography; Cancer
Identification of novel SAR properties of the Jak2 small molecule inhibitor G6: Significance of the para-hydroxyl orientation
Keywords: مهار کننده مولکول کوچک; Jak2 tyrosine kinase; G6; Small molecule inhibitor; Stilbenoid; SAR
Some natural flavonoids are competitive inhibitors of caspase-1, -3, and -7 despite their cellular toxicity
Keywords: مهار کننده مولکول کوچک; Apoptosis; Caspase; Flavonoid; Breast cancer; Enzyme kinetics; Small molecule inhibitor;
Comparison of the antitumor effects of an MDM2 inhibitor, nutlin-3, in feline lymphoma cell lines with or without p53 mutation
Keywords: مهار کننده مولکول کوچک; Cat; TP53; Murine double minute 2; Small molecule inhibitor