SMC6 is an essential gene in mice, but a hypomorphic mutant in the ATPase domain has a mild phenotype with a range of subtle abnormalities
Keywords: HR, homologous recombination; MEF, mouse embryonic fibroblast; MMC, mitomycin C; MMS, methyl methanesulfonate; SCE, sister chromatid exchange; SMC, structural maintenance of chromosomes; UV, ultraviolet lightDNA repair; Mouse model; Sister-chromatid excha