دانلود مقالات ISI درباره Sofosbuvir + ترجمه فارسی

Post-treatment resistance analysis of hepatitis C virus from phase II and III clinical trials of ledipasvir/sofosbuvir

Keywords: Hepatitis C virus; Drug resistance; NS5A; NS5B; DAA; Ledipasvir; Sofosbuvir; Ribavirin;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2017 سفارش ترجمه

Effectiveness and Tolerability of Direct Acting Antiviral Therapy for Hepatitis C in a Real World Elderly Cohort

Keywords: DAA; direct acting antiviral; HCV; hepatitis C virus; LDV; ledipasvir; RBV; ribavirin; SMV; simeprevir; SOF; sofosbuvir; SVR12; sustained virologic response;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2017 سفارش ترجمه

Cost-Effectiveness Analysis of New HCV Treatments in Egyptian Cirrhotic and Non-Cirrhotic Patients: A Societal Perspective

Keywords: cost-effectiveness; daclatasvir; Egypt; hepatitis C virus; ledipasvir; sofosbuvir;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2017 سفارش ترجمه

NS5A resistance-associated substitutions in patients with genotype 1 hepatitis C virus: Prevalence and effect on treatment outcome

Keywords: NS5A RAS; HCV genotype 1; Ledipasvir; Sofosbuvir; Sustained virologic response; Genotype; Treatment outcome;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2017 سفارش ترجمه

Safety and efficacy of daclatasvir-sofosbuvir in HCV genotype 1-mono-infected patients

Keywords: Chronic hepatitis C; Treatment; Sofosbuvir; Daclatasvir; Direct antiviral agents; Cirrhosis; Severe fibrosis; Genotype 1; Hepather cohort;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2017 سفارش ترجمه

UPLC-MS/MS method for determination of sofosbuvir in human plasma

Keywords: Sofosbuvir; UPLC-MS/MS; Method validation; Human plasma; Stability studies; Sofosbuvir; UPLC-MS/MS; La validation de méthode; Plasma humain; Études de stabilité;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2017 سفارش ترجمه

Effectiveness, safety and clinical outcomes of direct-acting antiviral therapy in HCV genotype 1 infection: Results from a Spanish real-world cohort

Keywords: Hepatitis C, Chronic; Genotype 1; Ombitasvir; Paritaprevir; Ritonavir; Dasabuvir; Ledipasvir; Sofosbuvir; Real-world; Antiviral agents; Sustained virologic response; Randomized controlled trials;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2017 سفارش ترجمه

Efficacy and Safety of Ledipasvir/Sofosbuvir with and without Ribavirin in Patients with Chronic Hepatitis C Virus Genotype 1 Infection: a meta-analysis

Keywords: Ledipasvir; Sofosbuvir; Ribavirin; Hepatitis C virus infection; Meta-analysis;

دانلود رایگان متن کامل مقاله ISI 16 صفحه سال انتشار : 2017 سفارش ترجمه

Real-World Effectiveness and Safety of Oral Combination Antiviral Therapy for Hepatitis C Virus Genotype 4 Infection

Keywords: Routine Clinical Practice; Direct-Acting Antiviral Agents; Cirrhosis; Genotype 4; DAA; direct-acting antiviral agent; EOT; end of treatment; GT; genotype; HCV; hepatitis C virus; LDV; ledipasvir; OMV; ombitasvir; PTV; paritaprevir; r; ritonavir; RBV; riba

دانلود رایگان متن کامل مقاله ISI 17 صفحه سال انتشار : 2017 سفارش ترجمه

Potential of RP-UHPLC-DAD-MS for the qualitative and quantitative analysis of sofosbuvir in film coated tablets and profiling degradants

Keywords: Film coated tablets; Mass spectrometry; RP-UHPLC; Sofosbuvir;

دانلود رایگان متن کامل مقاله ISI 19 صفحه سال انتشار : 2017 سفارش ترجمه

Effects of All-Oral Anti-Viral Therapy on HVPG and Systemic Hemodynamics in Patients With Hepatitis C Virus-Associated Cirrhosis

Keywords: Antiviral Therapy; Direct-acting Antivirals; Liver Disease; Portal Hypertension; AUROC; areas under the receiver operating characteristic curve; CPT; Child-Pugh Turcotte; CPT-B; Child-Pugh Turcotte-stage B; CSPH; clinically significant portal hypertension

دانلود رایگان متن کامل مقاله ISI 41 صفحه سال انتشار : 2017 سفارش ترجمه

Sofosbuvir and Velpatasvir Combination Improves Patient-reported Outcomes for Patients With HCV Infection, Without or With Compensated or Decompensated Cirrhosis

Keywords: PRO; Quality of Life; Direct-Acting Antivirals; DAA; CLDQ-HCV; Chronic Liver Disease Questionnaire-HCV Version; CPT; Child-Pugh-Turcotte; FACIT-F; Functional Assessment of Chronic Illness Therapy-Fatigue; HCV; hepatitis C virus; PRO; patient-reported outc

دانلود رایگان متن کامل مقاله ISI 42 صفحه سال انتشار : 2017 سفارش ترجمه

Análisis coste-efectividad del tratamiento de la hepatitis C crónica con sofosbuvir-simeprevir en pacientes con genotipo 1 y fibrosis avanzada

Keywords: Hepatitis C; Sofosbuvir; Simeprevir; Coste-efectividadHepatitis C; Sofosbuvir; Simeprevir; Cost-effectiveness

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2016 سفارش ترجمه

Simultaneous determination of ledipasvir, sofosbuvir and its metabolite in rat plasma by UPLC–MS/MS and its application to a pharmacokinetic study

Keywords: Ledipasvir; Sofosbuvir; GS-331007; UPLC–MS/MS; Plasma; Pharmacokinetics

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2016 سفارش ترجمه

Severe Pulmonary Arterial Hypertension in Patients Treated for Hepatitis C With Sofosbuvir

Keywords: drug induced; hepatitis C virus; pulmonary arterial hypertension; sofosbuvir;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2016 سفارش ترجمه

Les nouveaux médicaments de l’infectiologie

Keywords: dasabuvir; lédipasvir; ombitasvir; paritaprévir; ritonavir; sofosbuvir; virus varicelle-zonadasabuvir; ledipasvir; ombitasvir; paritaprevir; ritonavir; sofosbuvir; varicella-zoster virus

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2016 سفارش ترجمه

Outcomes after successful direct-acting antiviral therapy for patients with chronic hepatitis C and decompensated cirrhosis

Keywords: HCV; hepatitis C virus; DAA; direct-acting antiviral; MELD; model for end-stage liver disease; SVR; sustained virological response; EAP; expanded access programme; HCVRUK; hepatitis C Research UK; SOF; sofosbuvir; LDV; ledipasvir; DCV; daclatasvir; RBV; r

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2016 سفارش ترجمه

Effectiveness and safety of sofosbuvir plus ribavirin for HCV genotype 2 patients 65 and over with or without cirrhosis

Keywords: Hepatitis C virus; Gerontology; Cirrhosis; Sofosbuvir; Ribavirin; DAA; HCV; hepatitis C virus; PEG-IFNα; pegylated interferon alpha; DAA; direct-acting antiviral; ITPA; inosine triphosphate pyrophosphatase; eGFR; estimated glomerular filtration rate; IL2

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2016 سفارش ترجمه

Research ArticlePharmacokinetics, safety and efficacy of a full dose sofosbuvir-based regimen given daily in hemodialysis patients with chronic hepatitis C

Keywords: HCV; hepatitis C Virus; ESRD; end-stage renal disease; DAAs; direct-acting anti-HCV agents; SOF; sofosbuvir; LDV; ledipasvir; SOF-007TP; sofosbuvir uridine-triphosphate; SOF-007; predominant sofosbuvir inactive metabolite GS-331007; QD; once daily; TIW; t

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2016 سفارش ترجمه

Sustained virologic response to interferon-free therapies ameliorates HCV-induced portal hypertension

Keywords: HVPG; hepatic venous pressure gradient; ACLD; advanced chronic liver disease; HCV; hepatitis C virus; PegIFN/RBV; pegylated interferon and ribavirin; SVR; sustained virologic response; IFN; interferon; SOF; sofosbuvir; TE; transient elastography; BL; base

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2016 سفارش ترجمه

Research ArticleDysregulation of distal cholesterol biosynthesis in association with relapse and advanced disease in CHC genotype 2 and 3 treated with sofosbuvir and ribavirin

Keywords: HCV; Sofosbuvir; Ribavirin; Lipid metabolism;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2016 سفارش ترجمه

Quantification of sofosbuvir and ledipasvir in human plasma by UPLC-MS/MS method: Application to fasting and fed bioequivalence studies

Keywords: Sofosbuvir; Ledipasvir; UPLC-MS/MS; Plasma; Validation; Bioequivalence;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2016 سفارش ترجمه

Daclatasvir and Sofosbuvir Versus Sofosbuvir and Ribavirin in Patients with Chronic Hepatitis C Coinfected with HIV: A Matching-adjusted Indirect Comparison

Keywords: daclatasvir; hepatitis C; HIV; matching-adjusted indirect comparison; sofosbuvir; ribavirin;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2016 سفارش ترجمه

Research ArticleClinical value of on-treatment HCV RNA levels during different sofosbuvir-based antiviral regimens

Keywords: SOF; sofosbuvir; CAP/CTM; COBAS AmpliPrep/COBAS TaqMan v2.0; ART; Abbott RealTime HCV test; GT; genotype; RBV; ribavirin; PegIFN; pegylated-interferon alfa; SMV; simeprevir; HCV; hepatitis C virus; SVR; sustained virological response; DAA; direct-acting a

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2016 سفارش ترجمه

A model-based meta-analysis of sofosbuvir-based treatments in chronic hepatitis C patients

Keywords: Sofosbuvir; Meta-analysis; Hepatitis C virus; Modelling; Simulation

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2016 سفارش ترجمه

Characterization of forced degradation products and in silico toxicity prediction of Sofosbuvir: A novel HCV NS5B polymerase inhibitor

Keywords: Sofosbuvir; Degradation behavior; LC-ESI-QTOF–MS/MS; In silico toxicity

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2016 سفارش ترجمه

NS5A resistance leading to failure of 24-week therapy with sofosbuvir/ledipasvir and ribavirin for the treatment of hepatitis C genotype 1a infection in a HIV-1 co-infected patient

Keywords: ALT; alanine aminotransferase; AST; aspartate aminotransferase; cART; combination antiretroviral therapy; DAA; direct-acting antiviral; DDI; drug-drug interaction; EOTR; end-of-treatment response; GT; genotype; HCV; hepatitis C virus; HIV-1; human immun

دانلود رایگان متن کامل مقاله ISI 15 صفحه سال انتشار : 2016 سفارش ترجمه

Sofosbuvir Inhibits Hepatitis E Virus Replication In Vitro and Results in an Additive Effect When Combined With Ribavirin

Keywords: Antiviral; Chronic Hepatitis; Immunosuppression; Polymerase Inhibitor; gt; genotype; HCV; hepatitis C virus; HEV; hepatitis E virus; IC50; 50% inhibitory concentration; ORF; open reading frame; RBV; ribavirin; SOF; sofosbuvir;

دانلود رایگان متن کامل مقاله ISI 17 صفحه سال انتشار : 2016 سفارش ترجمه

Efficacy of the Combination of Sofosbuvir, Velpatasvir, and the NS3/4A Protease Inhibitor GS-9857 in Treatment-Naïve or Previously Treated Patients With Hepatitis C Virus Genotype 1 or 3 Infections

Keywords: Clinical Trial; LEPTON; Difficult to Treat; Time of Treatment; DAA; direct-acting antiviral agent; HCV; hepatitis C virus; PEG+RBV; pegylated interferon plus ribavirin; RAS; resistance-associated substitution; SOF; sofosbuvir; SVR12; sustained virologic r

دانلود رایگان متن کامل مقاله ISI 22 صفحه سال انتشار : 2016 سفارش ترجمه

Unexpected high rate of early tumor recurrence in patients with HCV-related HCC undergoing interferon-free therapy

Keywords: HCV; hepatitis C virus; DAA; direct-acting antivirals; SVR; sustained virological response; MELD; model for end-stage liver disease; HCC; hepatocellular carcinoma; BCLC; Barcelona Clinic Liver Cancer group; LOD; limit of detection; EOT; end of treatment;

دانلود رایگان متن کامل مقاله ISI 34 صفحه سال انتشار : 2016 سفارش ترجمه

Safety and Effectiveness of Direct-Acting Antiviral Agents for Treatment of Patients With Chronic Hepatitis C Virus Infection and Cirrhosis

Keywords: Chronic Hepatitis C; Direct-Acting Antivirals; Decompensation; Safety; CI; confidence interval; CP; Child-Pugh; DAA; direct-acting antiviral; HCC; hepatocellular carcinoma; HCV; hepatitis C virus; HR; hazard ratio; MELD; model for end-stage liver diseas

دانلود رایگان متن کامل مقاله ISI 38 صفحه سال انتشار : 2016 سفارش ترجمه

Effectiveness of Ledipasvir-Sofosbuvir Combination in Patients With Hepatitis C Virus Infection and Factors Associated With Sustained Virologic Response

Keywords: DAA; NS5A Inhibitor; NS5B Inhibitor; Antiviral; AE; adverse events; CI; confidence interval; HCV; hepatitis C virus; LDV; ledipasvir; OR; odds ratio; PPI; proton pump inhibitor; RBV; ribavirin; SOF; sofosbuvir; SVR; sustained virologic response; SVR12; su

دانلود رایگان متن کامل مقاله ISI 44 صفحه سال انتشار : 2016 سفارش ترجمه

Serious Pulmonary Toxicity Secondary to Novel Hepatitis C Antiviral Therapy in a Liver Transplant Recipient

Keywords: DAA; direct-acting antiviral agent; DAD; diffuse alveolar damage; FDA; Food and Drug Administration; HCV; hepatitis C virus; LT; liver transplant; SIM; simeprevir; SOF; sofosbuvir;

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2015 سفارش ترجمه

Evaluation of a rapid method for the simultaneous quantification of ribavirin, sofosbuvir and its metabolite in rat plasma by UPLC–MS/MS

Keywords: Ribavirin; Sofosbuvir; GS-331007; UPLC–MS/MS; Plasma; Pharmacokinetics

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2015 سفارش ترجمه

Hepatitis C

Keywords: Cirrhosis; directly acting antiviral agents; hepatitis C virus; hepatocellular carcinoma; interferon; people who inject drugs; ribavirin; sofosbuvir

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2015 سفارش ترجمه

Review ArticleInterferon-free therapy for hepatitis C: The hurdles amid a golden era

Keywords: Daclatasvir; Hepatitis C; Interferon; Simeprevir; Sofosbuvir;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2015 سفارش ترجمه

Development of a sensitive UPLC-ESI-MS/MS method for quantification of sofosbuvir and its metabolite, GS-331007, in human plasma: Application to a bioequivalence study

Keywords: Sofosbuvir; GS-331007; UPLC-MS/MS; Plasma; Validation; Bioequivalence

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2015 سفارش ترجمه

Clinical Trial Watch: Reports from the EASL International Liver Congress (ILC), Vienna, April 2015

Keywords: SOF; Sofosbuvir; DCV; Daclatasvir; RBV; Ribavirin; CP; Child-Pugh; SVR; Sustained virologial response; HVPG; Hepatic venous pressure gradient; G; Genotype; LDV; Ledipasvir; GZR; grazoprevir; EBR; Elbasvir; SMV; Simeprevir; CKD; Chronic kidney disease; RAV

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2015 سفارش ترجمه

Outcome and management of HCV/HIV coinfection pre- and post-liver transplantation. A 2015 update

Keywords: Liver transplantation; HCV; HIV; Coinfection; Direct antiviral agents; DAA; Pegylated-interferon; Ribavirin; Simeprevir; Sofosbuvir; Liver retransplantation; Hepatocellular carcinoma;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2015 سفارش ترجمه

Hepatitis C Virus

Keywords: Direct-acting antivirals; Sofosbuvir; Ledipasvir; Paritaprevir; Ombitasvir; Egypt; Access to treatment; Screening;

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2015 سفارش ترجمه

Current and Evolving Treatments of Genotype 1 Hepatitis C Virus

Keywords: Hepatitis C; Hepatitis; Sofosbuvir; Simeprevir; Cirrhosis; Ledipasvir antiviral;

دانلود رایگان متن کامل مقاله ISI 19 صفحه سال انتشار : 2015 سفارش ترجمه

Finding Truth in a World Full of Spin: Myth-Busting in the Case of Sovaldi

Keywords: budget impact; cost; Harvoni; hepatitis C; Sofosbuvir; Sovaldi;

دانلود رایگان متن کامل مقاله ISI 21 صفحه سال انتشار : 2015 سفارش ترجمه

An Odyssey in antiviral drug development-50 years at the Rega Institute: 1964-2014

Keywords: Erik De Clercq; Antiviral drug; Poly(I)·poly(C); Polyacrylic acid; Interferon; Reverse transcriptase; Suramin; Valaciclovir; Brivudin; Stavudine; Tenofovir disoproxil fumarate (TDF); Truvada®; Atripla®; Complera®/Eviplera®; Stribild®; FV-100; Mozobi

دانلود رایگان متن کامل مقاله ISI 24 صفحه سال انتشار : 2015 سفارش ترجمه

Simeprevir and Sofosbuvir for Treatment of Chronic Hepatitis C Infection

Keywords: HCV; hepatitis C; simeprevir; sofosbuvir;

دانلود رایگان متن کامل مقاله ISI 25 صفحه سال انتشار : 2015 سفارش ترجمه

Liver, Pancreas and Biliary TractSofosbuvir plus daclatasvir for post-transplant recurrent hepatitis C: Potent antiviral activity but no clinical benefit if treatment is given late

Keywords: Cholestatic hepatitis; Cirrhosis; Daclatasvir; Direct antiviral agents; Disease recurrence; HCV; MELD; Sofosbuvir;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2014 سفارش ترجمه

Review ArticleThe evolution of the therapeutic strategy in hepatitis C: Features of sofosbuvir and indications

Keywords: Guidelines; Hepatitis C; Sofosbuvir;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2014 سفارش ترجمه

Review ArticleEfficacy of sofosbuvir-based therapies in HIV/HCV infected patients and persons who inject drugs

Keywords: Hepatitis C virus; Human immune deficiency virus; Injection drugs users; Sofosbuvir;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2014 سفارش ترجمه

Beyond sofosbuvir: What opportunity exists for a better nucleoside/nucleotide to treat hepatitis C?

Keywords: Sofosbuvir; GS-7977; Sovaldi™; HCV nucleotide polymerase inhibitors; Prodrug; Hepatitis C

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2014 سفارش ترجمه

Hepatitis C treatment: an incipient therapeutic revolution

Keywords: hepatitis C; pegylated interferon; NS3–4A serine protease inhibitors; direct-acting antivirals (DAAs); sofosbuvir; simeprevir

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2014 سفارش ترجمه

Efficacy and safety of sofosbuvir-based therapy for the treatment of chronic hepatitis C in treatment-naïve and treatment-experienced patients

Keywords: Hepatitis C; Sofosbuvir; Pegylated interferon-α; Ribavirin; Meta-analysis

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2014 سفارش ترجمه