Keywords: آسیب عصب آسیب دیده; Chronic pain; Neuropathic pain; Nonopiate analgesia; Opioids; Venoms; ASIC; Acid-sensing ion channel; CbTx; Cobratoxin; CCI; Chronic constriction injury; DBV; Diluted bee venom; GABA; γ-Aminobutyric acid; GFAP; Glial fibrillary acidic protein; HNTX-IV; Î
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Keywords: آسیب عصب آسیب دیده; mGluR7; Dorsal striatum; Spared nerve injury; Mechanical allodynia; Rostral ventromedial medulla; Medullary dorsal reticular nucleus; ACSF; artificial cerebrospinal fluid; ADX71743; 6-(2,4-dimethylphenyl)-2-ethyl-6,7-dihydro-4(5H)-benzoxazolone; AMN082; N
Keywords: آسیب عصب آسیب دیده; CNS; central nervous system; TNF-α; tumor necrosis factor-α; IL-1β; interleukin-1β; NO; nitric oxide; ROS; reactive oxygen species; TGF-β; transforming growth factor-beta; AGE; alkyl glycerol ethers; CCI; chronic constriction injury; PBS; phosphate b
Keywords: آسیب عصب آسیب دیده; Omega-3, -6 and -9 fatty acids; Spared nerve injury; Spinal cord injury; Neurotrophic factor; Central sensitisation to noxious stimuli; Descending antinociception; Microglia; NMDA receptors;
Keywords: آسیب عصب آسیب دیده; CCI; chronic constriction injury; CNS; central nervous system; DLF; dorsal portion of the lateral funiculus; PBS; phosphate-buffered saline; RVM; rostral ventromedial medulla; SNI; spared nerve injury; SNL; spinal nerve ligation; TPH; tryptophan hydroxyla
Keywords: آسیب عصب آسیب دیده; Neuropathic pain; Spared nerve injury; Spinal cord; Prefrontal cortex; Microglia/macrophages; Minocycline;
Keywords: آسیب عصب آسیب دیده; ANOVA; analysis of variance; CCI; chronic constriction injury; IgG; immunoglobulin G; IL; Interleukin; IR; immunoreactivity; JOR; jaw-opening reflex; MOD; mean optical density; PWT; paw withdrawal threshold; RN; red nucleus; SNI; spared nerve injury; TGF-
Keywords: آسیب عصب آسیب دیده; NCE; new chemical entity; SNI; spared nerve injury; SNL; spinal nerve ligation; PR; progressive ratio; 5-CSRTT; 5-choice serial reaction time task; SD; stimulus duration; ITI; inter trial interval; LH; limited hold; ICSS; intracranial self-stimulation; Nb
Keywords: آسیب عصب آسیب دیده; Dopamine neurons; Serotonin neurons; Dopamine receptors; Electrophysiology; Spared nerve injury; Allodynia; Neuropathic pain; Rostromedial tegmental nucleus;
Keywords: آسیب عصب آسیب دیده; Red nucleus; Tumor necrosis factor receptor; Spared nerve injury; Neuropathic pain;
Keywords: آسیب عصب آسیب دیده; MicroPET; FDG; Neuropathic pain; Spared nerve injury; Formalin model;
Keywords: آسیب عصب آسیب دیده; ACC; anterior cingulate cortex; ALB; anxiety-like behavior; BDNF; brain-derived neurotrophic factor; BLA; basolateral nuclei of amygdala; BrDU; bromodeoxyuridine; BV; bee venom; CCI; chronic constriction injury; CeA; central nuclei of amygdala; CeLC; late
Keywords: آسیب عصب آسیب دیده; BDNF; brain derived neurotrophic factor; CAMKII; calmodulin-dependent protein kinase II; Ca2+; calcium; cAMP; cyclic adenosine monophosphate; CBS; cystathionine-β-synthase; CCI; chronic constriction injury; CFA; complete Freund's adjuvant; cGMP; cyclic
Ultra-micronized palmitoylethanolamide rescues the cognitive decline-associated loss of neural plasticity in the neuropathic mouse entorhinal cortex-dentate gyrus pathway
Keywords: آسیب عصب آسیب دیده; Spared nerve injury; pamitoylethanolamide; long term potentiation; PPARα; cognitive performance; synaptogenesis;
Norepinephrine-induced downregulation of GLT-1 mRNA in rat astrocytes
Keywords: آسیب عصب آسیب دیده; Astrocyte; Descending inhibitory pathway; Glutamate transporter; Neuropathic pain; Norepinephrine; Spinal cord; ANOVA; analysis of variance; DAPI; 4â²,6-diamidino-2-phenylindole; DMEM; Dulbecco's Modified Eagle's Medium; EDTA; ethylenediaminetetraacetic
Activation of 5-HT2A Receptors Restores KCC2 Function and Reduces Neuropathic Pain after Spinal Cord Injury
Keywords: آسیب عصب آسیب دیده; DIOA; [(dihydroindenyl)oxy]alkanoic acid; DRG; dorsal root ganglia; KCC2; potassium chloride cotransporter type 2; SCI; spinal cord injury; SNI; spared nerve injury; TCB-2; (4-bromo-3,6-dimethoxybenzocyclobuten-1-yl)methylamine hydrobromide; spinal cord i
Red nucleus interleukin-6 participates in the maintenance of neuropathic pain through JAK/STAT3 and ERK signaling pathways
Keywords: آسیب عصب آسیب دیده; Red nucleus; Interleukin-6; Signaling pathway; Neuropathic pain; Spared nerve injury;
IL-33/ST2 Pathway as a Rational Therapeutic Target for CNS Diseases
Keywords: آسیب عصب آسیب دیده; AD; Alzheimer's disease; ALS; amyotrophic lateral sclerosis; CCI; chronic constriction injury; CNS; central nervous system; EAE; experimental autoimmune encephalomyelitis; ECM; experimental cerebral malaria; ICH; intracerebral hemorrhage; IL-1RAcp; IL-1
Oxidative Stress in the Amygdala Contributes to Neuropathic Pain
Keywords: آسیب عصب آسیب دیده; CeA; central nucleus of the amygdala; Chem; Chembridge-5861528; DAAO; D-amino acid oxidase; LPBN; lateral parabrachial nucleus; PAG; periaqueductal gray; PBN; Phenyl-N-tert-butylnitrone; ROS; reactive oxygen species; RVM; rostroventromedial medulla; SNI;
Activation of ERK/CREB pathway in noradrenergic neurons contributes to hypernociceptive phenotype in H4 receptor knockout mice after nerve injury
Keywords: آسیب عصب آسیب دیده; Neuropathic pain; Histamine H4 receptor; ERK; CREB; Spinal noradrenergic neurons; (ATF3); activating transcription factor 3; (CREB); cAMP response element-binding protein; (DβH); dopamine beta-hydroxylase; (ERK); Extracellular signal-regulated kinases;
Research articleThe new HDAC1 inhibitor LG325 ameliorates neuropathic pain in a mouse model
Keywords: آسیب عصب آسیب دیده; CCI; chronic constriction injury; HAT; histone acetyltransferases; HDAC; histone deacetylase; i.t.; intrathecal; PSL; partial sciatic nerve ligation; SNI; spared nerve injury; SNL; spinal nerve ligation; Neuropathic pain; HDAC1, LG325, mechanical allodyni
Crocetin attenuates spared nerve injury-induced neuropathic pain in mice
Keywords: آسیب عصب آسیب دیده; Crocetin; Neuropathic pain; Spared nerve injury; Neuroinflammation; Oxidative stress;
Analgesic effect of coumarins from Radix angelicae pubescentis is mediated by inflammatory factors and TRPV1 in a spared nerve injury model of neuropathic pain
Keywords: آسیب عصب آسیب دیده; CRAP; Coumarins from Radix angelicae pubescentis; SNI; spared nerve injury; DRG; dorsal root ganglion; CRAP; coumarins from Radix angelicae pubescentis; IL-1β; interleukin-1β; IL-6; interleukin-6; TNF-α; tumor necrosis factor-α; TRPV1; Transient recep
Spinal activation of the NPY Y1 receptor reduces mechanical and cold allodynia in rats with chronic constriction injury
Keywords: آسیب عصب آسیب دیده; AUC; area under the curve; CCI; chronic constriction injury; CFA; complete freund's adjuvant; DRG; dorsal root ganglion; NPY; neuropeptide tyrosine; SLNC; single ligature nerve constriction; SNI; spared nerve injury; VGLUT2; vesicular glutamate transpor
Redox-guided axonal regrowth requires cyclic GMP dependent protein kinase 1: Implication for neuropathic pain
Keywords: آسیب عصب آسیب دیده; ATF3; Activating transcription factor-3; ADF; Actin depolymerizing factor; cGMP; cyclic guonosine monophosphate; Cre; Cre recombinase; DRG; Dorsal root ganglia; EYFP; Enhanced yellow fluorescent protein; GAP43; Growth associated protein 43; IP3; Inositol
Infant nerve injury induces delayed microglial polarization to the M1 phenotype, and exercise reduces delayed neuropathic pain by modulating microglial activity
Keywords: آسیب عصب آسیب دیده; CD; cluster differentiation; IL; interleukin; iNOS; inducible nitric oxide synthase; IT; intrathecal; MYD88; myeloid differentiation factor; P; postnatal day; POD; postoperative day; QPCR; quantitative polymerase chain reaction; SNI; spared nerve injury;
Downregulation of ClC-3 in dorsal root ganglia neurons contributes to mechanical hypersensitivity following peripheral nerve injury
Keywords: آسیب عصب آسیب دیده; ClC-3; Dorsal root ganglia; Mechanical hypersensitivity; Peripheral nerve injury; Neuropathic pain; DRG; dorsal root ganglia; KO; knockout; WT; wild type; SNI; spared nerve injury; Ad-ClC-3; adenovirus vector expressing ClC-3; siRNA; small interference RN
Transcriptional expression of inflammatory mediators in various somatosensory relay centers in the brain of rat models of peripheral mononeuropathy and local inflammation
Keywords: آسیب عصب آسیب دیده; NGF; nerve growth factor; DRG; dorsal root ganglia; ET; endotoxin; ELISA; enzyme-linked immunosorbent assay; DH; dorsal horn; SNI; spared nerve injury; CCI; chronic constriction injury; ET; endotoxin; LPS; lipopolysaccharide; VF; Von Frey; PW; paw withdra
A new model of nerve injury in the rat reveals a role of Regulator of G protein Signaling 4 in tactile hypersensitivity
Keywords: آسیب عصب آسیب دیده; CB1 receptor; cannabinoid type-1 receptor; DRG; dorsal root ganglion; GFAP; glial fibrillary acidic protein; Iba1; ionized calcium-binding adapter molecule 1; MPE; maximum-possible-effect; mSNI; modified spared nerve injury; PWT; paw withdrawal threshold;
Noradrenergic Locus Coeruleus pathways in pain modulation
Keywords: آسیب عصب آسیب دیده; Locus Coeruleus; noradrenaline; norepinephrine; pain; neuropathic pain; inflammatory pain; ACC; anterior cingulate cortex; AMY; amygdala; AMPA; α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid; APS; Air-puff stimulation; AVV; adenoviral vector; CCI;
TRESK contributes to pain threshold changes by mediating apoptosis via MAPK pathway in the spinal cord
Keywords: آسیب عصب آسیب دیده; ANOVA; analysis of variance; DRG; dorsal root ganglia; ERK; extracellular signal-regulated kinase; IL; interleukin; JNK; c-Jun N-terminal kinase; K2P; two-pore domain K+; MAPK; mitogen-activated protein kinase; MCP-1; monocyte chemotactic protein-1; MIP-2
Modulation of spinal glial reactivity by intrathecal PPF is not sufficient to inhibit mechanical allodynia induced by nerve crush
Keywords: آسیب عصب آسیب دیده; Nerve injury; Inflammation; Treatment; Spared nerve injury; Pain; Motor function;
Research paperEarly treatment with UR13870, a novel inhibitor of p38α mitogenous activated protein kinase, prevents hyperreflexia and anxiety behaviors, in the spared nerve injury model of neuropathic pain
Keywords: آسیب عصب آسیب دیده; Spared nerve injury; Neuropathic pain; p38α MAPK inhibitor; Antinociception; Microglia; OX-42; Place escape/avoidance paradigm; Open field induced anxiety test;
Analgesic effect of total flavonoids from Sanguis draxonis on spared nerve injury rat model of neuropathic pain
Keywords: آسیب عصب آسیب دیده; Total flavonoids from Sanguis draxonis; Spared nerve injury; Neuropathic pain; Astrocyte; Pro-inflammatory cytokinesSD, Sanguis draxonis; D. cochinchinensis, Dracaena cochinchinensis (Lour.) S. C. Chen; SDF, total flavonoids from SD; SNI, spared nerve inj
Analgesic effects and possible mechanisms of iridoid glycosides from Lamiophlomis rotata (Benth.) Kudo in rats with spared nerve injury
Keywords: آسیب عصب آسیب دیده; Lamiophlomis rotate (Benth.) Kudo; Iridoid glycosides; NMDAR/PKC; NO/cGMP/PKG; Spared nerve injury; Neuropathic pain;
Research ReportChanges in VGLUT2 expression and function in pain-related supraspinal regions correlate with the pathogenesis of neuropathic pain in a mouse spared nerve injury model
Keywords: آسیب عصب آسیب دیده; VGLUT; vesicular glutamate transporter; SNI; spared nerve injury; CSB6B; Chicago Sky Blue 6B; EAAT; excitatory amino acid transporter; PAG; periaqueductal gray; mPFC; medial prefrontal cortex; ACSF; artificial cerebrospinal fluid; PB; phosphate-buffer; PB
RGS9-2 modulates sensory and mood related symptoms of neuropathic pain
Keywords: آسیب عصب آسیب دیده; Spared nerve injury; Forced swim; Chronic pain; Thermal hyperalgesia; Mechanical allodynia; Signal transduction; Nociception;
Lack of effect of a P2Y6 receptor antagonist on neuropathic pain behavior in mice
Keywords: آسیب عصب آسیب دیده; DRG; dorsal root ganglion; i.t; intrathecal; SNI; spared nerve injury; Purinergic signaling; Nerve injury; Neuropathic pain; Dorsal root ganglia; Spinal cord;
The rostroventromedial medulla is engaged in the effects of spinal cord stimulation in a rodent model of neuropathic pain
Keywords: آسیب عصب آسیب دیده; ANOVA; analysis of variance; AUC; area under curve; DLF; dorsolateral funiculus; MT; motor threshold; RVM; rostroventromedial medulla; SCS; spinal cord stimulation; SD; standard deviation; SNI; spared nerve injury; WT; withdrawal thresholds; neuropathic p
Periaqueductal gray stimulation suppresses spontaneous pain behavior in rats
Keywords: آسیب عصب آسیب دیده; DBS; deep-brain stimulation; PAG; periaqueductal gray; SNI; spared nerve injury; Analgesia; PAG-DBS; Neuropathic pain; Allodynia;
Analgesic effect of iridoid glycosides from Paederia scandens (LOUR.) MERRILL (Rubiaceae) on spared nerve injury rat model of neuropathic pain
Keywords: آسیب عصب آسیب دیده; Iridoid glycosides of Paederia scandens; Spared nerve injury; Neuropathic pain; Withdrawal threshold; NO/cGMP/PKG
Neuropathic pain and reactive gliosis are reversed by dialdehydic compound in neuropathic pain rat models
Keywords: آسیب عصب آسیب دیده; ATP, adenosine triphosphate; Ox-ATP, oxidized ATP; SNI, spared nerve injury; pPPN, paclitaxel evoked painful peripheral neuropathy; CNS, central nervous systemOxidized ATP; MED1101; Dialdehydic compounds; Spared nerve injury; Paclitaxel; Reactive astrocyt
The role of dopamine receptors in ventrolateral orbital cortex-evoked anti-nociception in a rat model of neuropathic pain
Keywords: آسیب عصب آسیب دیده; ventrolateral orbital cortex; dopamine receptor; anti-nociception; neuropathic pain; GABAergic modulation; rat; Apomorphine; R(â)-apomorphine hydrochloride; bicuculline; (+)-bicuculline, (S), 9(R); i.p.; intraperitoneally; Muscimol; muscimol hydrochlori
Early blockade of injured primary sensory afferents reduces glial cell activation in two rat neuropathic pain models
Keywords: آسیب عصب آسیب دیده; satellite glial cells; spontaneous activity; GFAP; spinal nerve ligation; spared nerve injury; nerve growth factorDRG, dorsal root ganglion; GFAP, glial fibrillary acidic protein; MAP kinase, mitogen-activate protein kinase; Neu-N, neuronal nuclei; NGF, n
Adrenergic regulation of P2X3 and TRPV1 receptors: Differential effects of spared nerve injury
Keywords: آسیب عصب آسیب دیده; P2X3 receptors; TRPV1 receptors; Noradrenaline; Spared nerve injury;
Tumor necrosis factor-α of Red nucleus involved in the development of neuropathic allodynia
Keywords: آسیب عصب آسیب دیده; Neuropathic pain; Red nucleus; Tumor necrosis factor-α; Spared nerve injury; Rat
Tactile allodynia can occur in the spared nerve injury model in the rat without selective loss of GABA or GABAA receptors from synapses in laminae I-II of the ipsilateral spinal dorsal horn
Keywords: آسیب عصب آسیب دیده; neuropathic pain; dorsal horn; GABAA receptor β3 subunit; postembedding immunocytochemistry; vesicular GABA transporter; antigen retrieval; CCI; chronic constriction injury; DAB; 3,3â²-diaminobenzidine; EPSC; excitatory postsynaptic current; GAD; glutam
Intrathecal Rosiglitazone Acts at Peroxisome Proliferator–Activated Receptor-γ to Rapidly Inhibit Neuropathic Pain in Rats
Keywords: آسیب عصب آسیب دیده; Allodynia; hyperalgesia; rat; 16-deoxy-prostaglandin-J2; spared nerve injury; pioglitazone
Intrathecal neuropeptide Y reduces behavioral and molecular markers of inflammatory or neuropathic pain
Keywords: آسیب عصب آسیب دیده; Spared nerve injury; Formalin; Allodynia; Hyperalgesia; Rat; c-fos;
Lumbar Sympathectomy Attenuates Cold Allodynia But Not Mechanical Allodynia and Hyperalgesia in Rats With Spared Nerve Injury
Keywords: آسیب عصب آسیب دیده; Neuropathic pain; sympathectomy; spared nerve injury;