
The potential and challenges of CRISPR-Cas in eradication of hepatitis B virus covalently closed circular DNA
Keywords: CHB; chronic hepatitis B; HBV; hepatitis B virus; NA; nucleos(t)ide analogue; cccDNA; covalently closed circular DNA; guide RNA; gRNA; NTCP; sodium taurocholate cotransporting polypeptide; RC-DNA; relaxed circular DNA; pgRNA; pregenomic RNAs; HBsAg; HBV s