Keywords: ss، تک رشته; ALKBH, AlkB homolog; 1-meA, 1-methyladenine; 3-meC, 3-methylcytosine; 2OG, 2-oxoglutarate; FTO, fat mass and obesity-associated; ss, single-stranded; ds, double-stranded; CRPC, castrate resistant prostate cancer; NACLC, non-small cell lung cancer; LC-MS/M
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The in vitro Biochemical Characterization of an HIV-1 Restriction Factor APOBEC3F: Importance of Loop 7 on Both CD1 and CD2 for DNA Binding and Deamination
Keywords: ss، تک رشته; CD, cytosine deaminase; ss, single-stranded; fl, full-lengthAPOBEC deaminases; APOBEC3F; Anti-HIV; DNA binding
POT1–TPP1 Binding and Unfolding of Telomere DNA Discriminates against Structural Polymorphism
Keywords: ss، تک رشته; ss, single-stranded; ssDNA, single-stranded DNA; nt, nucleotide; POT1, Protection of telomeres 1; OB, oligonucleotide binding; SE-HPLC, size-exclusion HPLC; CD, circular dichroism; EMSA, electrophoretic mobility shift assays; TBE, Tris/Borate/EDTAtelomere
Control of RecBCD Enzyme Activity by DNA Binding- and Chi Hotspot-Dependent Conformational Changes
Keywords: ss، تک رشته; ds, double-stranded; ss, single-stranded; Bpa, p-benzoyl-l-phenylalanine; SAXS, small-angle X-ray scattering; EDTA, ethylenediaminetetraacetic acid; bp, base-pair; kDa, kilodalton; PBS, phosphate-buffered saline; TCEP, tris(2-carboxyethyl)phosphinehelicas
Detection of DNA hybridization by field-effect DNA-based biosensors: mechanisms of signal generation and open questions
Keywords: ss، تک رشته; FED, field-effect device; EISOI, electrolyte-insulator–semiconductor silicon-on-insulator structure; GNP, gold nano-particle; ss, single-stranded; ds, double-stranded; bp, base pair; ES, electrostatic; PB, Poisson–Boltzmann; [salt], salt concentrationDNA
Structure and Stoichiometry of Template-Directed Recombinant HIV-1 Gag Particles
Keywords: ss، تک رشته; HIV-1, human immunodeficiency virus type 1; MA, matrix; CA, capsid; NC, nucleocapsid; VLP, virus-like particle; TEM, transmission electron microscopy; PEG, polyethylene glycol; ss, single-stranded; DLS, dynamic light scattering; EM, electron microscopy; 3
A structural model for regulation of NHEJ by DNA-PKcs autophosphorylation
Keywords: ss، تک رشته; DNA-PK, DNA-dependent protein kinase; DNA-PKcs, DNA-PK catalytic subunit; ds, double-stranded; DSB, DNA double strand break; IR, ionizing radiation; NHEJ, non-homologous end joining; ss, single-stranded; SAXS, small angle X-ray scattering; XLF, XRCC4 like
Uracil-DNA glycosylase: Structural, thermodynamic and kinetic aspects of lesion search and recognition
Keywords: ss، تک رشته; ds, double stranded; ODN(s), oligodeoxyribonucleotide(s); Eco-Ung, uracil-DNA glycosylase from Escherichia coli; hUNG, human uracil-DNA glycosylase; ss, single-stranded; UNG, uracil-DNA N-glycosylaseDNA repair; DNA glycosylases; Uracil-DNA glycosylase; St
Alternating 2′-O-ribose methylation is a universal approach for generating non-stimulatory siRNA by acting as TLR7 antagonist
Keywords: ss، تک رشته; Dendritic cells; Innate immunity; 2′-O-ribose methylation; siRNA; Toll-like receptorβ2m, beta-2-microglobulin; ds, double-stranded; eGFP, enhanced green fluorescence protein; siRNA, small interfering RNA; ss, single-stranded; TLRs, Toll-like receptors
Coupling Translocation with Nucleic Acid Unwinding by NS3 Helicase
Keywords: ss، تک رشته; molecular motor; helicase; DNA/RNA unwinding; diffusion; stochastic simulationNS3, nonstructural protein 3; ss, single-stranded; ds, double-stranded; SF, superfamily; HCV, hepatitis C virus
Post-transcriptional gene silencing as an efficient tool for engineering resistance to white clover mosaic virus in white clover (Trifolium repens)
Keywords: ss، تک رشته; AMV, alfalfa mosaic virus; AS, antisense orientation; CYVV, clover yellow vein virus; dpi, days post inoculation; PR, partially resistant; R, resistant; ss, single-stranded; S, sense orientation; S, susceptible; WCMVrep, WCMV replicase gene; WCMV, white c
Fluorescence-based detection of short DNA sequences under non-denaturing conditions
Keywords: ss، تک رشته; PNA, peptide nucleic acid; bis-PNA or PNA openers, two PNA oligomers connected by a flexible linker; RCA, rolling-circle amplification; MB, molecular beacon; ds, double-stranded; ss, single-stranded; HTLV-1, human T-lymphotropic virus type 1; EBV, Epstein
Effects of trichostatin A on neuronal mu-opioid receptor gene expression
Keywords: ss، تک رشته; MOR, mu-opioid receptor; PCBP, poly C binding protein 1; ds, double-stranded; ss, single-stranded; TSA, trichostatin A; HDAC, histone deacetylase; HAT, histone acetyltransferase; CNS, central nervous system; ChIP, chromatin immunoprecipitation; Act D, act
Synergistic action of the Saccharomyces cerevisiae homologous recombination factors Rad54 and Rad51 in chromatin remodeling
Keywords: ss، تک رشته; HR, homologous recombination; ss, single-stranded; ds, double-stranded; NTA, nitrilotriacetic acid; BSA, bovine serum albumin; GST, glutathione-S-transferaseRad51; Rad54; Chromatin remodeling; D-loop; Homologous recombination
The mRNA-binding Site of Annexin A2 Resides in Helices C–D of its Domain IV
Keywords: ss، تک رشته; AnxA2, annexin A2 protein; anxA2, annexin A2 cDNA or mRNA; AnxA2-DIV, domain IV of annexin A2; MBP, maltose binding protein; RU, resonance units; SA, streptavidin; SPR, surface plasmon resonance; ss, single-stranded; TEV, tobacco etch virus; Tm, transitio
The Roles of Tyr391 and Tyr619 in RB69 DNA Polymerase Replication Fidelity
Keywords: ss، تک رشته; Exo, proofreading exonuclease domain; Pol, polymerase domain; indel, addition or deletion of any number of bases; ss, single-stranded; ds, double-strandedDNA replication; replication fidelity; bacteriophage RB69; DNA polymerase; proofreading
Mechanism of interaction between human 8-oxoguanine-DNA glycosylase and AP endonuclease
Keywords: ss، تک رشته; AP, apurinic/apyrimidinic; BER, base excision repair; BSA, bovine serum albumin; DTT, dithiothreitol; EMSA, electrophoretic mobility shift assay; ODN, oligodeoxyribonucleotide; PAGE, polyacrylamide gel electrophoresis; ss, single-stranded; ds, double-stra
Crystal Structure and Activity of Kunjin Virus NS3 Helicase; Protease and Helicase Domain Assembly in the Full Length NS3 Protein
Keywords: ss، تک رشته; KUNV, Kunjin virus; WNV, West Nile virus; YFV, yellow fever virus; DENV, Dengue virus; HCV, hepatitis C virus; RTPase, 5′-terminal RNA triphosphatase activity; ss, single-stranded; ds, double-stranded; NS3FL, full length KUNV NS3 protein; SAXS, small angl
A Dual-nuclease Mechanism for DNA Break Processing by AddAB-type Helicase-nucleases
Keywords: ss، تک رشته; ss, single-stranded; ds, double-stranded; ExoI, Exonuclease IDNA recombination; DNA repair; DNA helicase; RecBCD; AddAB
Specific Recognition of a DNA Immunogen by its Elicited Antibody
Keywords: ss، تک رشته; ss, single-stranded; ds, double-stranded; mAb, monoclonal antibody; CDR, complementarity determining region; SLE, Systemic Lupus Erythematosus; HPV, human papillomavirus; E2c, C-terminal domain of E2 protein from HPVanti-DNA; structure; antibody; autoimmu
Structural Studies of E. coli Topoisomerase III-DNA Complexes Reveal a Novel Type IA Topoisomerase-DNA Conformational Intermediate
Keywords: ss، تک رشته; ss, single-stranded; ds, double-stranded; r.m.s.d., root mean square deviationtopoisomerase III; structure; complexes; ssDNA
Dodecameric Structure and ATPase Activity of the Human TIP48/TIP49 Complex
Keywords: ss، تک رشته; TIP, TBP/transcription activating interacting protein; IPTG, isopropyl-1-thio-β-D-galactopyranoside; PMSF, phenylmethylsulphonyl fluoride; BSA, bovine serum albumin; ss, single-stranded; ds, double-stranded; AAA+, ATPases associated with different cellula
Gene Expression Analysis in Blood Cells in Response to Unmodified and 2′-Modified siRNAs Reveals TLR-dependent and Independent Effects
Keywords: ss، تک رشته; TLR, Toll-like receptor; PBMC, peripheral blood mononuclear cells; ss, single-stranded; ds, double-stranded; siRNA, small interfering RNA; RISC, RNA-induced silencing complex; IFN, interferon; TNF, tumor necrosis factor; IL, interleukin; PKR, dsRNA-depend
A set of recombineering plasmids for gram-negative bacteria
Keywords: ss، تک رشته; bp, base pair(s); nt, nucleotide(s); PCR, polymerase chain reaction; ts, temperature-sensitive; ori, origin of replication; ds, double-stranded; ss, single-stranded; CmR, chloramphenicol resistant; ApR, ampicillin resistant; TcR, tetracycline resistant; c
The p53-induced Wig-1 protein binds double-stranded RNAs with structural characteristics of siRNAs and miRNAs
Keywords: ss، تک رشته; ds, double-stranded; dsRBP, double-stranded RNA binding protein; FL, full-length; GST, glutathione S-transferase; miRNA, micro RNA; NLS, nuclear localization signal; siRNA, small interfering RNA; ss, single-stranded; Tet, tetracyclineWig-1; p53; dsRNA; Zi
Escherichia coli RecA promotes strand invasion with cisplatin-damaged DNA
Keywords: ss، تک رشته; RecA; Recombination; DNA damage; Cisplatin; D-loop; Single-strand binding proteinCisplatin, cis-diamminedichloroplatinum II; D-loop, displacement loop; NPF, Nucleoprotein filament; SSB, Single-strand binding protein; ss, Single-stranded
Unwinding Single RNA Molecules Using Helicases Involved in Eukaryotic Translation Initiation
Keywords: ss، تک رشته; 5′UTR, 5′ untranslated region; AFM, atomic force microscopy; ss, single-stranded; ds, double-strandedprotein–RNA interactions; translation initiation; helicases; atomic force microscopy
Rapid Kinetics of Protein–Nucleic Acid Interaction is a Major Component of HIV-1 Nucleocapsid Protein’s Nucleic Acid Chaperone Function
Keywords: ss، تک رشته; NC, nucleocapsid protein; aa, amino acid; ss, single-stranded; ds, double-stranded; HIV-1, human immunodeficiency virus type-1; FIM, force-induced melting; WT, wild-typenucleocapsid protein; nucleic acid chaperone; single molecule DNA stretching; DNA melt
Ig-Like Domains on Bacteriophages: A Tale of Promiscuity and Deceit
Keywords: ss، تک رشته; bacteriophage; Ig-like domain; morphogenetic proteins; misannotation; frameshiftingds, double-stranded; ss, single-stranded; ORF, open reading frame; Ig, immunoglobulin; HOC, highly immunogenic outer capsid; MTP, major tail protein; MHP, major head protei
T-rich DNA Single Strands Bind to a Preformed Site on the Bacterial Cold Shock Protein Bs-CspB
Keywords: ss، تک رشته; CSP, cold shock protein; RNP, ribonucleoprotein; OB, oligonucleotide/oligosaccharide binding; Ec, Escherichia coli; Bs, Bacillus subtilis; Bc, Bacillus caldolyticus; Tm, Thermotoga maritima; ss, single-stranded; PDB, Protein Data Bankcold shock proteins;
Molecular basis underlying the poly C binding protein 1 as a regulator of the proximal promoter of mouse μ-opioid receptor gene
Keywords: ss، تک رشته; MOR, μ-opioid receptor; PCBP, poly C binding protein 1; ss, single-stranded; KH domain, K homology domain; hnRNP K, heterogeneous nuclear ribonucleoprotein K; EMSA, electrophoresis mobility shift assayKH domain; Variable domain; Poly C binding protein 1;
A New Model for Schizosaccharomyces pombe Telomere Recognition: The Telomeric Single-stranded DNA-Binding Activity of Pot11-389
Keywords: ss، تک رشته; OB fold, oligonucleotide/oligosaccharide binding fold; ss, single-stranded; SpPot1, S. pombe protection of telomeres protein 1chromosome end protection; OB fold; Pot1; single-stranded DNA binding; telomeres
Transgene structures suggest that multiple mechanisms are involved in T-DNA integration in plants
Keywords: ss، تک رشته; ds, double-stranded; DSB, double-strand break; DSBR, double-strand break repair; LB, T-DNA left border; NHEJ, non-homologous end-joining; RB, T-DNA right border; ss, single-stranded; SSA, single-strand annealing; SDSA, synthesis-dependent strand annealing
Transmission Electron Microscopy Reveals an Optimal HIV-1 Nucleocapsid Aggregation with Single-stranded Nucleic Acids and the Mature HIV-1 Nucleocapsid Protein
Keywords: ss، تک رشته; HIV, human immunodeficiency virus; NCp, nucleocapsid protein; ss, single-stranded; ds, double-stranded; EM, electron microscopy; TEM, transmission electron microscopy; gp32, T4-encoded gene 32 protein; SSB, single-stranded binding; G4 DNA, parallel DNA qu
Histidine Triad-like Motif of the Rotavirus NSP2 Octamer Mediates both RTPase and NTPase Activities
Keywords: ss، تک رشته; ds, double-stranded; ss, single-stranded; DLP, double-layered particle; RdRP, RNA-dependent RNA polymerase; NTPase, nucleoside-triphosphate phosphohydrolase; PKCI, protein kinase C-interacting protein; HIT, histidine triad; RTPase, RNA triphosphatase; VLS