Keywords: محرک ژن های اینترفرون; PTP1B; protein tyrosine phosphatase 1B; CNS; central nervous system; HFD; high fat diet; NPY; neuropeptide Y; AMPK; 5' AMP-activated protein kinase; BAT; brown adipose tissue; AF; albiflorin; hAMSCs; human adipose tissue-derived mesenchymal stem cells; PP
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Keywords: محرک ژن های اینترفرون; RT; radiation therapy; IFN-γ; interferon-γ; TLR; toll-like receptor; STAT; signal transducer and activator of transcription; NF-κB; nuclear factor-κB; CXCLs; C-X-C motif ligands; CCLs; C-C motif ligands; iNOS; inducible nitric oxide synthase; IL; inte
Keywords: محرک ژن های اینترفرون; PRR; pattern recognition receptor; PAMP; pathogen-associated molecular pattern; DAMP; danger-associated molecular pattern; NLRP3; NOD-, LRR- and pyrin domain-containing 3; TLR; toll-like receptor; CLR; C-type lectin receptor; NLR; NOD-like receptor; RIG-I
Keywords: محرک ژن های اینترفرون; Cytokines; Signal transduction; Drug development; Inflammation; Autoimmunity; Therapy; JAK; Janus Kinase; STAT; Signal transducer and activator of transcription; NF-kB; nuclear factor kappa-light-chain-enhancer of activated B cells; MAPK; Mitogen activate
Keywords: محرک ژن های اینترفرون; Immunology; primary immunodeficiency; whole-exome sequencing; hematopoietic stem cell transplantation; common variable immunodeficiency; severe combined immunodeficiency; hyper-IgE syndrome; AIP1; Actin-interacting protein 1; APDS; Activated PI3Kδ syndro
Keywords: محرک ژن های اینترفرون; 2-DG; 2-deoxy glucose; Akt; protein kinase B; ARDS; acute respiratory distress syndrome; Arg; arginase; BALF; broncho-alveolar lavage fluid; BCG; Bacillus Calmette-Guérin; CD; cluster of differentiation; cGAS; cyclic GMP-AMP synthase; COX-2; cyclooxyge
Keywords: محرک ژن های اینترفرون; autoinflammation; autoinflammatory; gangrene; genodermatosis; inflammation; interferonopathy; interstitial lung disease; vasculitis; IFN; interferon; JAK; Janus kinase; NIH; National Institutes of Health; SAVI; stimulator of interferon genes-associated
Keywords: محرک ژن های اینترفرون; 17-AAG; 17-(Allylamino)-17-demethoxygeldanamycin; 17-DMAG; 17-Dimethylaminoethylamino-17-demethoxygeldanamycin; AKT; v-akt murine thymoma viral oncogene homolog; APC; antigen presenting cell; ATM; Ataxia telangiectasia mutated; ATR; Ataxia telangiectasia
Keywords: محرک ژن های اینترفرون; central nervous system; Toll-like receptors; retinoic acid-inducible gene 1; antiviral immunity; stimulator of interferon genes
Keywords: محرک ژن های اینترفرون; AIM2; absent in melanoma 2; AP-1; activating protein-1; APOBEC; apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like; AZT; azidothymidine; CCCR5; C-C chemokine receptor type 5; CDK1; cyclin-dependent kinase 1; CXCR4; C-X-C chemokine receptor t
STING positively regulates human ORMDL3 expression through TBK1-IRF3-STAT6 complex mediation
Keywords: محرک ژن های اینترفرون; ORMDL3; orosomucoid 1-like protein 3; GWAS; genome-wide association studies; EBV; Epstein-Barrvvirus; HRV; human rhinovirus; RSV; respiratory syncytial virus; STING; Stimulator of interferon genes; TLR; Toll-like receptors; NF-κB; nuclear factor κB; IFN
Polyglutamine binding protein 1 (PQBP1) inhibits innate immune responses to cytosolic DNA
Keywords: محرک ژن های اینترفرون; PQBP1; polyglutamine binding protein 1; cGAS; cyclic GMP-AMP synthase; IFI16; interferon- γ-inducible protein 16; IFN; interferon; STING; Stimulator of Interferon Genes; TBK; tank-binding kinase-1; DNA sensing; PQBP1; cGAS; IFI16; pattern recognition rec
DNA damage, metabolism and aging in pro-inflammatory T cells
Keywords: محرک ژن های اینترفرون; EC; endothelial cell; ROS; reactive oxygen species; ATP; adenosine 5â²-triphosphate; ER; endoplasmic reticulum; mtDNA; mitochondrial DNA; ETC; electron transport chain; mROS; mitochondrial ROS; NADPH; nicotinamide adenine dinucleotide phosphate; TNF-α;
Butyrate ameliorated-NLRC3 protects the intestinal barrier in a GPR43-dependent manner
Keywords: محرک ژن های اینترفرون; T2DM; type 2 diabetes; PRRs; pattern recognition receptors; TLRs; toll-like receptors; NOD; nucleotide-binding oligomerization domain; NLRs; nucleotide-binding oligomerization domain (NOD)-like receptors; MAMPs; microbe-associated molecular patterns; NLRP
Mutational game changer: Chromothripsis and its emerging relevance to cancer
Keywords: محرک ژن های اینترفرون; SAC; spindle assembly checkpoint; APOBEC; apolipoprotein B mRNA-editing catalytic subunit; SNP; single-nucleotide polymorphism; array-CGH; comparative genomic hybridization; CLTP; chromothripsis-like pattern; SKY; spectral karyotyping; FISH; fluorescent i
Activation of the STING-IRF3 pathway promotes hepatocyte inflammation, apoptosis and induces metabolic disorders in nonalcoholic fatty liver disease
Keywords: محرک ژن های اینترفرون; ALT; Alanine aminotransferase; AST; Aspartate aminotransferase; AUC; Area under the curve; BW; body weight; DMEM; Dulbecco's modified Eagle's medium; ER; endoplasmic-reticulum; FBS; fetal bovine serum; FFA; free fatty acid; GCK; glucokinase; p-GSK3β; pho
STING Signaling Promotes Inflammation in Experimental Acute Pancreatitis
Keywords: محرک ژن های اینترفرون; Mouse Model; Apoptosis; Signal Transduction; Innate Immunity; ACS; acinar cell culture supernatant; AP; acute pancreatitis; BM; bone marrow; BMDM; BM-derived macrophages; CDE; choline-deficient diet supplemented with DL-ethionine; cGAS; cyclic GMP-AMP syn
HBV Bypasses the Innate Immune Response and Does Not Protect HCV From Antiviral Activity of Interferon
Keywords: محرک ژن های اینترفرون; Coinfection; Interferon-stimulated Gene; PRR; RIG-I; APOBEC; apolipoprotein B mRNA editing enzyme catalytic subunit; cccDNA; covalently closed circular DNA; CHB; chronic hepatitis B; circDNA; circular DNA; GFP-IRF3; green fluorescent protein-interferon
Human microglia and astrocytes express cGAS-STING viral sensing components
Keywords: محرک ژن های اینترفرون; AMP; adenosine monophosphate; ATCC; American type tissue collection; ANOVA; analysis of variance; BDNA; B-form DNA; CNS; central nervous system; cDNA; complementary DNA; cGAS; cyclic GMP-AMP synthase; DAI; DNA-dependent activator of interferon-regulatory
Intracellular DNA sensing pathway of cGAS-cGAMP is decreased in human newborns and young children
Keywords: محرک ژن های اینترفرون; CBMCs; cord blood mononuclear cells; CBP; CREB-binding protein; cGAS; cyclic GMP-AMP synthase; cGAMP; cyclic GMP-AMP; EBV; Epstein-Barr virus; GAPDH; glyceraldehyde-3-phosphate dehydrogenase; HCMV; human cytomegalovirus; HSV-1; herpes simplex virus type 1
Innate immunity related pathogen recognition receptors and chronic hepatitis B infection
Keywords: محرک ژن های اینترفرون; acLDL; acylated LDL; AIM2; absent in melanoma 2; AP-1; activator protein 1; BDCA-2; blood DC antigen; BEC; biliary epithelial cells; CARD; caspase recruitment and activation domains; cDC; common dendritic cells; CL-L1; collectin liver 1; CL-K1; collectin
The Emerging Roles of STING in Bacterial Infections
Keywords: محرک ژن های اینترفرون; STING; Stimulator of Interferon Genes; DNA and nucleotide sensing; bacteria; infections;
Human B cells fail to secrete type I interferons upon cytoplasmic DNA exposure
Keywords: محرک ژن های اینترفرون; IFN I; type I interferon(s); IFI16; interferon-inducible protein 16; cGAMP; cyclic GMP-AMP; cGAS; cGAMP synthase; STING; stimulator of interferon genes; TBK1; TANK-binding kinase 1; IRF3; interferon regulatory factor 3; ISG; interferon-stimulated genes; P
The function of feline stimulator of interferon gene (STING) is evolutionarily conserved
Keywords: محرک ژن های اینترفرون; Feline; STING; Type I IFN; Activation; STING; Stimulator of interferon genes; ER; Endoplasmic reticulum; IRF3; Interferon regulatory factor 3; NF-κB; Nuclear factor kappa-light-chain-enhancer of activated B cells; JNK; c-jun N-terminal kinase; AP-1; Acti
Natural STING Agonist as an “Ideal” Adjuvant for Cutaneous Vaccination
Keywords: محرک ژن های اینترفرون; alum; aluminum salt; cdGMP; cyclic di-guanosine monophosphate; cGAMP; 2â²3â²-cyclic guanosine monophosphate-adenosine monophosphate; GFP; green fluorescent protein; HA; hemagglutinin; HAI; hemagglutination inhibition; ID; intradermal or intradermally; I
The role of mitochondrial DNA damage in the development of atherosclerosis
Keywords: محرک ژن های اینترفرون; AMPK; AMP activated protein kinase; cGAS; cyclic GMP-AMP synthase; DAMP; damage-associated molecular pattern; Drp1; dynamin-related protein 1; FGF21; fibroblast growth factor 21; IFN; interferon; MOMP; mitochondrial outer membrane permeabilisation; MPTP;
Yersinia YopJ negatively regulates IRF3-mediated antibacterial response through disruption of STING-mediated cytosolic DNA signaling
Keywords: محرک ژن های اینترفرون; BMDMs; bone marrow-derived macrophages; c-di-GMP; cyclic diguanylate monophosphate; DMEM; Dulbecco's modified Eagle's medium; ER; endoplasmic reticulum; FBS; fetal bovine serum; GST; Glutathione S-transferase; HEK293T; human embryonic kidney; IB; immunobl
The emerging role of human PYHIN proteins in innate immunity: Implications for health and disease
Keywords: محرک ژن های اینترفرون; AIM2; absent in melanoma 2; ALR; AIM2-like receptor; ASC; apoptosis-associated speck-like protein containing a CARD; CARD; caspase activation and recruitment domain; cGAMP; cyclic GMP-AMP; cGAS; cGAMP synthase; DAI; DNA-dependent activator of IFN-regulato
Research ArticleHepatitis C virus NS4B blocks the interaction of STING and TBK1 to evade host innate immunity
Keywords: محرک ژن های اینترفرون; HCV; hepatitis C virus; PAMP; pathogen-associated molecular pattern; STING; stimulator of interferon genes; MITA; mediator of IRF3 activation; SeV; Sendai virus; ER; endoplasmic reticulum; Hepatitis C virus; Interferon; NS4B; STING/MITA; TBK-1;