A focused fragment library targeting the antibiotic resistance enzyme - Oxacillinase-48: Synthesis, structural evaluation and inhibitor design
Keywords: Crystal structure; Inhibition properties; Benzoic acid derivatives; Serine-β-lactamase inhibitors; Fragments; Structure-guided drug design; DMSO; dimethyl sulfoxide; OXA; oxacillinase; IC50; half maximal inhibitory concentration; LE; ligand efficiency; M