Keywords: اعتبار سنجی هدف; Quantitative systems pharmacology; Process-oriented modeling; OpenBEL; Predictive platform; Target validation;
مقالات ISI اعتبار سنجی هدف (ترجمه نشده)
مقالات زیر هنوز به فارسی ترجمه نشده اند.
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در صورتی که به ترجمه آماده هر یک از مقالات زیر نیاز داشته باشید، می توانید سفارش دهید تا مترجمان با تجربه این مجموعه در اسرع وقت آن را برای شما ترجمه نمایند.
Keywords: اعتبار سنجی هدف; Duloxetine HCl (PubChem CID: 60834); Morphine HCl (PubChem CID: 5464110); pregabalin (PubChem CID: 5486971)Translational research; Cynomolgus macaque; Osteoarthritis; Hyperalgesia; Target validation
Keywords: اعتبار سنجی هدف; Maturation; Human engineered cardiac tissue; Pluripotent stem cell-derived cardiomyocytes; Drug toxicity; Target validation; Regenerative medicine
Keywords: اعتبار سنجی هدف; Mass spectrometry; Reactive carbonyl species; Electrophilic lipids; Cyclopentenone prostaglandins; Target validation; Vimentin cysteine lipoxidationACR, acrolein; AGE, advanced glycation end product(s); ALE, advanced lipoxidation end product(s); CID, coll
Keywords: اعتبار سنجی هدف; Cancer models; Pancreatic ductal adenocarcinoma; Tumor microenvironment; Inflammation; Target validation; Therapeutic strategies;
Discovery of a novel 2-(1H-pyrazolo[3,4-b]pyridin-1-yl)thiazole derivative as an EP1 receptor antagonist and in vivo studies in a bone fracture model
Keywords: اعتبار سنجی هدف; EP1 receptor; Prostaglandin E2; Target validation; Oral administration; Bone fracture healing;
Acetazolamide-based [18F]-PET tracer: In vivo validation of carbonic anhydrase IX as a sole target for imaging of CA-IX expressing hypoxic solid tumors
Keywords: اعتبار سنجی هدف; Carbonic anhydrase IX; Acetazolamide; Hypoxic tumor; PET imaging; Target validation;
Disruption of blood meal-responsive serpins prevents Ixodes scapularis from feeding to repletion
Keywords: اعتبار سنجی هدف; Ixodes scapularis; Tick serpins; Target validation; Tick feeding physiology; Combinatorial RNAi silencing;
Absence of regulator of G-protein signaling 4 does not protect against dopamine neuron dysfunction and injury in the mouse 6-hydroxydopamine lesion model of Parkinson's disease
Keywords: اعتبار سنجی هدف; RGS4; Parkinson's disease; 6-OHDA; Mouse model; Histopathology; Behavior; Neuroprotection; Target validation; Substantia nigra;
RNA as a small molecule druggable target
Keywords: اعتبار سنجی هدف; Non-coding RNA; ncRNA; Drug target; Small molecule; Target validation; Functional;
Validation of Mycobacterium tuberculosis dihydroneopterin aldolase as a molecular target for anti-tuberculosis drug development
Keywords: اعتبار سنجی هدف; Site-directed mutagenesis; Gene knockout; Target validation; TB drug discovery; Essentiality evaluation;
The trypanothione system and its implications in the therapy of trypanosomatid diseases
Keywords: اعتبار سنجی هدف; Trypanothione synthetase; Trypanothione reductase; Tryparedoxin; Tryparedoxin peroxidases; Target validation; Drugability
The trypanothione system and the opportunities it offers to create drugs for the neglected kinetoplast diseases
Keywords: اعتبار سنجی هدف; Antioxidant defense; DNA synthesis; Drugability; Drug target; Leishmaniasis; Target validation; Trypanosomiasis; Trypanothione; Trypanothione synthetase; Tryparedoxin
Identification and validation of protein targets of bioactive small molecules
Keywords: اعتبار سنجی هدف; Target identification; Target validation; Chemical biology; Small molecules; Protein targets;
Future drug discovery and development
Keywords: اعتبار سنجی هدف; Target-based drug discovery; Translational medicine; Target validation; Common disorders; Mendelian disorders
Identification of a κ-opioid agonist as a potent and selective lead for drug development against human African trypanosomiasis
Keywords: اعتبار سنجی هدف; Phenotypic screening; African trypanosomiasis; Target identification; Target validation; U50,488;
Malaria: Targeting parasite and host cell kinomes
Keywords: اعتبار سنجی هدف; Malaria; Protein kinase; Target validation; Plasmodium falciparum; Plasmodium berghei; Transgenesis; Transfection;
Integrating genomics across drug discovery and development
Keywords: اعتبار سنجی هدف; Genomics; Target validation; Disease mechanism; Compound optimization; Biomarkers; Pharmacogenetics
A reporter assay for target validation in primary neuronal cultures
Keywords: اعتبار سنجی هدف; Cortical neurons; Amyloid-β; Neurodegeneration; Target validation; Reporter assay;
Gene manipulation through the use of small interfering RNA (siRNA): From in vitro to in vivo applications
Keywords: اعتبار سنجی هدف; siRNA; shRNA; Transgenic; Transfection; Target validation; Lentiviral; Adenoviral; Therapeutic; siRNA design; Methods of delivery; Mammalian system
Target identification and validation in drug discovery: the role of proteomics
Keywords: اعتبار سنجی هدف; Proteomics; Drug discovery; Target validation; Target confidence building;
Biology calls the targets: combining RNAi and disease biology
Keywords: اعتبار سنجی هدف; Pharmaceutical Science; Drug Discovery; Cell biology; RNAi; Target discovery; Target validation; cellular assays; shRNA; siRNA; arrays; adenovirus; disease biology;
Exploring the sounds of silence: RNAi-mediated gene silencing for target identification and validation
Keywords: اعتبار سنجی هدف; Pharmaceutical Science; Drug Discovery; Genetics; RNAi; delivery; Gene expression profiling; target identification; target validation;
FT-ICR mass spectrometry in the drug discovery process
Keywords: اعتبار سنجی هدف; Drug Discovery; Pharmaceutical Science; Techniques & Methods; Target validation; Proteomics; Noncovalent complexes; Lead optimization; Natural products;
Integrated expressional analysis: Application to the drug discovery process
Keywords: اعتبار سنجی هدف; High content; Multiplex; TaqMan; RT-PCR; Gene expression; Target validation; Biomarkers; siRNA; Toxicity; Functional informatics;
Novel target sites in bacteria for overcoming antibiotic resistance
Keywords: اعتبار سنجی هدف; Bacterial genomics; Target validation; Compound libraries; Lead identification; New class antibacterials;
Stable isotope methods for high-precision proteomics
Keywords: اعتبار سنجی هدف; Drug Discovery; Pharmaceutical Science; Techniques & Methods; Mass defect; ICAT; iTRAQ; GIST; IDBEST; Biomarkers; Target validation;