The microtubule-associated protein tau is phosphorylated by Syk
Keywords: خود را; Tau; Tyrosine phosphorylation; Syk; Tauopathy;
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PerspectiveNew directions for frontotemporal dementia drug discovery
Keywords: خود را; Tau; TDP-43; Neurodegeneration; Frontotemporal dementia; Therapy; Prevention;
The LARK/RBM4a protein is highly expressed in cerebellum as compared to cerebrum
Keywords: خود را; RBM4; RBM4a; RBM4b; Lark; Hlark; RNA binding motif 4 protein; Monoclonal antibodies; mAb; RISC; Splicing; Alternative spilcing; Tau; Tauopathy; Protein expression; Tumour; Brain; Liver; Kidney; Cerebrum; Cerebellum;
Folate deprivation increases tau phosphorylation by homocysteine-induced calcium influx and by inhibition of phosphatase activity: Alleviation by S-adenosyl methionine
Keywords: خود را; Tau; Neurodegeneration; Folate; Homocysteine; S-adenosyl methionine; Alzheimer's disease
Expression of genes related to Parkinson’s disease after paraquat treatment in Drosophila melanogaster
Keywords: خود را; Paraquat; Parkinson’s disease; Drosophila; Gene expression; Oxidative stress; Parkin; UCH; tau; JNK signaling; SOD-reduced mutant files
The molecular pathology of Alzheimer’s disease
Keywords: خود را; amyloid; amyloid precursor protein; dementia; plaques; tangles; tau
No disease in the brain of a 115-year-old woman
Keywords: خود را; Atherosclerosis; Supercentenarian; Neurodegeneration; Tau; Locus coeruleus
Decreased glucose transporters correlate to abnormal hyperphosphorylation of tau in Alzheimer disease
Keywords: خود را; AD, Alzheimer disease; GFAP, glial fibrillary acidic protein; GlcNAc, β-N-acetylglucosamine; GLUTs, glucose transporters; HIF-1, hypoxia-inducible factor 1; NFTs, neurofibrillary tanglesGlucose transporters; Tau; Hyperphosphorylation; Alzheimer disease; O
NMR observation of Tau in Xenopus oocytes
Keywords: خود را; NMR; In-cell; Xenopus oocytes; Ficoll; Cell survival; Tau; Phosphorylation;
Lithium down-regulates tau in cultured cortical neurons: A possible mechanism of neuroprotection
Keywords: خود را; Lithium; Tau; Neurons; Amyloid; Apoptosis; Alzheimer
Parallel increase in p70 kinase activation and tau phosphorylation (S262) with Aβ overproduction
Keywords: خود را; Aβ; Tau; p70S6 kinase; Alzheimer’s disease
Abnormal phosphorylation of Ser409/410 of TDP-43 in FTLD-U and ALS
Keywords: خود را; Ubiquitin; Inclusions; Tau; α-synuclein; Degradation; Aggregation
Site-specific phosphorylation of Tau protein is associated with deacetylation of microtubules in mouse spermatogenic cells during meiosis
Keywords: خود را; Meiosis; Spermatogenesis; Testis; Tau
Leptin reduces Alzheimer’s disease-related tau phosphorylation in neuronal cells
Keywords: خود را; Leptin; Tau; Alzheimer’s disease; Insulin; AMPK; AICAR
Immortalized cortical neurons expressing caspase-cleaved tau are sensitized to endoplasmic reticulum stress induced cell death
Keywords: خود را; AD; Alzheimer's disease; NFT; neurofibrillary tangle; ER; endoplasmic reticulum; SERCA; sarco-endoplasmic reticula calcium-ATPase-type pumps; PARP; poly (ADP-ribose) polymerase; ERK; extracellular signal-regulated kinase; TUNEL; Terminal deoxynucleotidyl
Detection and quantification of tau aggregation using a membrane filter assay
Keywords: خود را; Tau; Aggregation; Alzheimer’s disease; Filter assay
Haplotype-specific expression of the N-terminal exons 2 and 3 at the human MAPT locus
Keywords: خود را; MAPT; tau; MAPT haplotype; Progressive supranuclear palsy; Corticobasal degeneration; Allele-specific expression; Tauopathy; Alternative splicing
Multiplexed quantification of dementia biomarkers in the CSF of patients with early dementias and MCI: A multicenter study
Keywords: خود را; Alzheimer's disease; Biomarkers; Amyloid; Tau; Cerebrospinal fluid; Multiplexing
Tau-isoform dependent enhancement of taxol mobility through microtubules
Keywords: خود را; Fluorescence recovery after photobleaching (FRAP); Microtubules; Microtubule-associated protein; Tau; Rebinding; Kinetic modeling; Transport though pores; Competition
Involvement of calpain and p25 of CDK5 pathway in ginsenoside Rb1's attenuation of β-amyloid peptide25-35-induced tau hyperphosphorylation in cortical neurons
Keywords: خود را; AD; Alzheimer's disease; Aβ; β-amyloid; MT; microtubule; CDK5; cyclin-dependent kinase 5; NFTs; neurofibrillary tangles; Ginsenoside Rb1; β-amyloid (Aβ); Tau; Cyclin-dependent kinase 5 (CDK5); p35; p25;
Hippocampal neuronal subpopulations are differentially affected in double transgenic mice overexpressing frontotemporal dementia and parkinsonism linked to chromosome 17 tau and glycogen synthase kinase-3β
Keywords: خود را; Alzheimer's disease; FTDP-17; GSK-3; tau; transgenic miceAD, Alzheimer's disease; EtOH, ethanol; FTDP-17, frontotemporal dementia and parkinsonism linked to chromosome 17; GFAP, glial fibrillary acidic protein; GSK-3β, glycogen synthase kinase-3β; NFT, ne
Multitracer PET imaging of amyloid plaques and neurofibrillary tangles in Alzheimer's disease
Keywords: خود را; Alzheimer; Amyloid beta; Tau; Neuropathology; Pet; Imaging
TGF-β1 protects against Aβ-neurotoxicity via the phosphatidylinositol-3-kinase pathway
Keywords: خود را; Amyloid; TGF-β1; SB431542; Hippocampus; Neurons; PI-3-K; Neuronal death; Cell cycle; β-catenin; Tau
Tau hyperphosphorylation correlates with reduced methylation of protein phosphatase 2A
Keywords: خود را; PP2A methylation; Aβ; Estrogen receptor; Tau; Alzheimer's disease
Pre-assembled tau filaments phosphorylated by GSK-3b form large tangle-like structures
Keywords: خود را; Tau; Alzheimer's disease; GSK-3β; Phosphorylation; Hyperphosphorylation; Neurofibrillary tangle; Polymerization
Microglial activation in brain lesions with tau deposits: Comparison of human tauopathies and tau transgenic mice TgTauP301L
Keywords: خود را; Microglia; Tau; Transgenic mice; Iba1; AT8; MHC class II
Hypometabolism and Altered Cerebrospinal Fluid Markers in Normal Apolipoprotein E E4 Carriers with Subjective Memory Complaints
Keywords: خود را; Alzheimer’s disease; amyloid beta; ApoE; CSF; FDG-PET; isoprostane; normal aging; subjective memory complaints; tau
Impairment of spatial learning and memory in ELKL Motif Kinase1 (EMK1/MARK2) knockout mice
Keywords: خود را; Aging; Learning and memory; Spatial navigation; Hippocampus; EMK1; MARK2; Protein kinase; Tau; Knockout mice; Radial-arm water maze
The novel calpain inhibitor A-705253 potently inhibits oligomeric beta-amyloid-induced dynamin 1 and tau cleavage in hippocampal neurons
Keywords: خود را; Alzheimer's disease; Proteolysis; Tau; Dynamin 1; Calpain inhibitors
Tauopathy in human and experimental variant Creutzfeldt-Jakob disease
Keywords: خود را; Variant Creutzfeldt-Jakob disease; Tau; Alzheimer disease; Tauopathy; Immunohistochemistry; Prion protein
Cholinergic Treatments with Emphasis on M1 Muscarinic Agonists as Potential Disease-Modifying Agents for Alzheimer's Disease
Keywords: خود را; Alzheimer's; cholinergic; β-amyloid; tau; acetylcholinesterase inhibitors; M1 muscarinic; nicotinic; agonists; M2 muscarinic antagonists;
A possible link between astrocyte activation and tau nitration in Alzheimer's disease
Keywords: خود را; Tau; Nitration; Alzheimer's disease; Astrocytes; Monoclonal antibody; Glial fibrillary acidic protein; Tyrosine
Phosphorylation of tau and α-synuclein in synaptic-enriched fractions of the frontal cortex in Alzheimer's disease, and in Parkinson's disease and related α-synucleinopathies
Keywords: خود را; α-synuclein; tau; Parkinson's disease; dementia with Lewy bodies; Alzheimer's disease; A53T transgenic mouse; AD; Alzheimer's disease; BS; buffered sucrose; DLB; dementia with Lewy bodies; DLBc; common form of Dementia with Lewy bodies; DLBp; pure
Peripheral elevation of IGF-1 fails to alter Aβ clearance in multiple in vivo models
Keywords: خود را; Aβ; Alzheimer's disease; IGF-1; Clearance; Tg2576; Tau
Females exhibit more extensive amyloid, but not tau, pathology in an Alzheimer transgenic model
Keywords: خود را; Alzheimer's disease; Transgenic mice; Amyloid beta; Beta-secretase; Neprilysin; Gender difference; Oligomer; Tau; Hyperphosphorylation
Aβ inhibits the proteasome and enhances amyloid and tau accumulation
Keywords: خود را; Proteasome; Alzheimer's disease; Amyloid beta; Tau; Transgenic; Oliogmers; Immunotherapy
Homocysteine induces tau phosphorylation by inactivating protein phosphatase 2A in rat hippocampus
Keywords: خود را; Alzheimer's disease; Homocysteine; Protein phosphatase 2A; Tau; Phosphorylation; Methylation
Ibuprofen reduces Aβ, hyperphosphorylated tau and memory deficits in Alzheimer mice
Keywords: خود را; Alzheimer; Amyloid; Tau; Immunohistochemistry; Cognitive test; Ibuprofen; Transgenic mice
Alpha7 nicotinic acetylcholine receptor: A link between inflammation and neurodegeneration
Keywords: خود را; Inflammation; Neurodegeneration; Alzheimer's disease; Microglia; Beta amyloid; Tau; Nicotinic receptors; Alpha7nicotinic receptors; Acetylcholine
Accumulation of beta-amyloid in the brain microvessels accompanies increased hyperphosphorylated tau proteins following microsphere embolism in aged rats
Keywords: خود را; microvascular; eNOS; peroxynitrite; beta-amyloid; tau; Alzheimer's diseaseAD, Alzheimer's disease; APP, amyloid precursor protein; CaMKII, Ca2+/calmodulin-dependent protein kinase II; eNOS, endothelial nitric oxide synthase; GSK3β, glycogen synthase kinas
Modulation of synaptic plasticity and Tau phosphorylation by wild-type and mutant presenilin1
Keywords: خود را; Presenilin; FAD mutation; Synaptic plasticity; NMDA receptor; Synaptic vesicles; Presynaptic; Postsynaptic; Tau
A novel transgenic mouse expressing double mutant tau driven by its natural promoter exhibits tauopathy characteristics
Keywords: خود را; Tauopathy; Tau; Mutation; Neurofibrillary tangles; Homologous tau promoter; Transgenic mice; LTP
Tau-Based Treatment Strategies in Neurodegenerative Diseases
Keywords: خود را; Tau; Alzheimer's disease; phosphorylation; aggregation; neurodegeneration; therapy;
Tau in cerebrospinal fluid: A sensitive sandwich enzyme-linked immunosorbent assay using tyramide signal amplification
Keywords: خود را; Tau; Cerebrospinal fluid; ELISA
p53 is upregulated in Alzheimer's disease and induces tau phosphorylation in HEK293a cells
Keywords: خود را; p53; Tau; Microtubules; Alzheimer's disease
Phenotypic associations of tau and ApoE in Parkinson's disease
Keywords: خود را; Tau; ApoE; Phenotype; Association study; Hallucinations; Dementia; Post-mortem;
Molecular associations in binary mixtures of pyridine and chlorobenzene in benzene solution using microwave absorption data
Keywords: خود را; D; Debye; ε; Epsilon; Ï; Tau; μ; Mau; CLB; Chlorobenzene.; Dielectric relaxation; Binary mixture; Pyridine; Chlorobenzene;
Amyloid-forming propensity of the hydrophobic non-natural amino acid on the fibril-forming core peptide of human tau
Keywords: خود را; Amyloid; Fibrils; Peptide; Non-natural amino acid; Aggregates; Tau; Pathogenic polypeptides
Diagnostic markers for diagnosing dementia with Lewy bodies: CSF and MIBG cardiac scintigraphy study
Keywords: خود را; Amyloid β; Tau; H/M ratio; Washout rate; Sympathetic nerve; Alzheimer's disease
The many faces of corticobasal degeneration
Keywords: خود را; Corticobasal syndrome (CBS); Corticobasal degeneration (CBD); Dementia; Frontotemporal dementia (FTD); Progressive non-fluent aphasia; Speech apraxia; Progressive cortical atrophy syndrome; Tau