Synthesis, biological evaluation, and molecular modeling studies of methylene imidazole substituted biaryls as inhibitors of human 17α-hydroxylase-17,20-lyase (CYP17)—Part II: Core rigidification and influence of substituents at the methylene bridge
Keywords: CYP, cytochrome P450; CAB, combined androgen blockade; GnRH, gonadotropin-releasing hormone; CYP17, 17α-hydroxylase-17,20-lyase; DHEA, dehydroepiandrosterone; DHT, dihydrotestosterone; CDI, 1,1-carbonyl diimidazole; TBDMS, tert-butyldimethylsilyl; TBDPS,