Synthesis and evaluation of analogs of the phenylpyridazinone NPD-001 as potent trypanosomal TbrPDEB1 phosphodiesterase inhibitors and in vitro trypanocidals
Keywords: MOE, Molecular Operating Environment; MW, microwave; TbrPDEB1, Trypanosoma brucei phosphodiesterase B1; TbrPDEB2, Trypanosoma brucei phosphodiesterase B2Pyridazinone; Phosphodiesterase; Trypanosome brucei; African trypanosomiasis; TbrPDEB1; Human PDEs