دانلود مقالات ISI درباره Tdp1 + ترجمه فارسی

ابزار مایعات اشعه برای تصحیح تعمیر پایه برش و تعمیر مجدد یک رشته

Micro-irradiation tools to visualize base excision repair and single-strand break repair

Keywords: DIQ; 1,5-dihydroxyisoquinoline; 4-AN; 4-amino-1,8-naphthalimide; 6,4PPs; 6,4-photoproducts; 8-oxodG; 8-oxo-2′-deoxyguanosine; OGG1; 8-oxoguanine glycosylase 1; APE1; AP-endonuclease; ATM; ataxia telangiectasia-mutated gene; BER; base excision repair; BR

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2015 سفارش ترجمه

پیوستن به انتهای غیرخطی: راه حل خوبی برای پایان دادن به بد است

Nonhomologous end joining: A good solution for bad ends

Keywords: Alt-EJ; alternative end joining; APLF; aprataxin and polynucleotide kinase/phosphatase-like factor; ATM; ataxia-telangiectasia mutated; ATR; ATM-, Rad3-related; APTX; aprataxin; β-Casp; metallo-β-lactamase-associated CPSF Artemis SNM1 PSO2; BER; base ex

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2014 سفارش ترجمه

Achyrodimer F, a tyrosyl-DNA phosphodiesterase I inhibitor from an Australian fungus of the family Cortinariaceae

Keywords: Achyrodimer F; Cyclobutane derivative; Tdp1; Fungus Cortinariaceae; DFT calculations;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2017 سفارش ترجمه

TDP1 is required for efficient non-homologous end joining in human cells

Keywords: TDP1; tyrosyl-DNA phosphodiesterase 1; TDP1-KO; TDP1-knockout; NHEJ; non-homologous end joining; Tyrosyl-DNA phosphodiesterase 1; TDP1; Non-homologous end joining; NHEJ; XLF;

دانلود رایگان متن کامل مقاله ISI 24 صفحه سال انتشار : 2017 سفارش ترجمه

XRCC1-mediated repair of strand breaks independent of PNKP binding

Keywords: XRCC1 phosphorylation; PNKP; PARP-1; Tdp1; Top1; Camptothecin; Hydrogen peroxide;

دانلود رایگان متن کامل مقاله ISI 47 صفحه سال انتشار : 2017 سفارش ترجمه

Tyrosyl-DNA phosphodiesterase inhibitors: Progress and potential

Keywords: DNA repair; Topoisomerase; Camptothecin; Top1 inhibitors; Top2 inhibitors; Tyrosyl-DNA phosphodiesterase; Tdp1; Tdp2; Tdp1 inhibitors; Tdp2 inhibitors; Indenoisoquinolines;

دانلود رایگان متن کامل مقاله ISI 31 صفحه سال انتشار : 2016 سفارش ترجمه

Synthesis and biological evaluation of novel tyrosyl-DNA phosphodiesterase 1 inhibitors with a benzopentathiepine moiety

Keywords: Tyrosyl-DNA phosphodiesterase 1; TDP1; TDP1 inhibitor; Pentathiepine; Molecular modeling

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2015 سفارش ترجمه

TDP1 promotes assembly of non-homologous end joining protein complexes on DNA

Keywords: Non-homologous end joining (NHEJ); TDP1; Ku70/80; XLF; DNA-dependent protein kinase (DNA-PK);

دانلود رایگان متن کامل مقاله ISI 23 صفحه سال انتشار : 2015 سفارش ترجمه

Identification of novel PARP inhibitors using a cell-based TDP1 inhibitory assay in a quantitative high-throughput screening platform

Keywords: TDP1; PARP; Topoisomerases; Drug discovery; Combination therapy

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2014 سفارش ترجمه

Development of an oligonucleotide-based fluorescence assay for the identification of tyrosyl-DNA phosphodiesterase 1 (TDP1) inhibitors

Keywords: TDP1; Assay; High-throughput screen; Fragment; Inhibitor; Topoisomerase;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2014 سفارش ترجمه

Enhanced DNA repair of bleomycin-induced 3′-phosphoglycolate termini at the transcription start sites of actively transcribed genes in human cells

Keywords: TCR; transcription coupled repair; TSS; transcription start site; TDP1; tyrosyl-DNA phosphodiesterase 1; PNKP; polynucleotide kinase 3′-phosphatase; APE1; apurinic/apyrimidinic endonuclease 1; Anti-tumour agent; Bleomycin; DNA damage; Next-generation se

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2014 سفارش ترجمه

Epigenetic and genetic inactivation of tyrosyl-DNA-phosphodiesterase 1 (TDP1) in human lung cancer cells from the NCI-60 panel

Keywords: TDP1; Topoisomerases; Topotecan; CellMiner; Promoter hypermethylation

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2014 سفارش ترجمه

DNA repair mechanisms in dividing and non-dividing cells

Keywords: DNA repair; Neural cells; Neurological disorder; Dividing and non-dividing; Endogenous DNA damage; AOA1; ataxia with ocular motor apraxia 1; AP; apurinic/apyrimidinic; APE1; AP endonuclease 1; APTX; aprataxin; ATM; ataxia telangiectasia mutated; CPDs; cyc

دانلود رایگان متن کامل مقاله ISI 17 صفحه سال انتشار : 2013 سفارش ترجمه

A fluorescence-based assay for the apurinic/apyrimidinic-site cleavage activity of human tyrosyl-DNA phosphodiesterase 1

Keywords: Tdp1; DNA repair; Assay; High-throughput screen; Inhibitor; Topoisomerase

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2013 سفارش ترجمه

Trypanosoma brucei AP endonuclease 1 has a major role in the repair of abasic sites and protection against DNA-damaging agents

Keywords: AP; apurinic/apyrimidinic; TBAPE1; Trypanosoma brucei AP endonuclease 1; LMAP; Leishmania major AP endonuclease; exoIII; exonuclease III; endoIV; endonuclease IV; OGG1; 8-oxoguanine DNA glycosylase 1; NTH1; endonuclease III; BSD; blasticidin S transferase

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2012 سفارش ترجمه

Inhibitors of human tyrosyl-DNA phospodiesterase (hTdp1) developed by virtual screening using ligand-based pharmacophores

Keywords: Human tyrosyl-DNA phosphodiesterase; Tdp1; Inhibitors; Small molecule docking; Drug design; Virtual screening

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2010 سفارش ترجمه

Virtual screening using ligand-based pharmacophores for inhibitors of human tyrosyl-DNA phospodiesterase (hTdp1)

Keywords: Human tyrosyl-DNA phosphodiesterase; Tdp1; Inhibitors; Small molecule docking; Drug design; Virtual screening

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2010 سفارش ترجمه

Synergistic decrease of DNA single-strand break repair rates in mouse neural cells lacking both Tdp1 and aprataxin

Keywords: Aprataxin; Tdp1; Single-strand breaks; Neural cells; Oxidative stress; Topoisomerase-1;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2009 سفارش ترجمه

DNA single-strand break repair and spinocerebellar ataxia with axonal neuropathy-1

Keywords: CPT; camptothecin; DSB; double-strand break; DSBR; double-strand break repair; HR; homologous recombination; LCL; lymphoblastoid cell line; SCAN1; spinocerebellar ataxia with axonal neuropathy; SSB; single-strand break; SSBR; single-strand break repair; T

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2007 سفارش ترجمه

A subgroup of spinocerebellar ataxias defective in DNA damage responses

Keywords: spinocerebellar ataxia; DNA repair; aprataxin; AOA; AOA1; ataxia oculomotor apraxia type 1; AOA2; ataxia oculomotor apraxia 2; A-T; ataxia-telangiectasia; ATLD; ataxia-telangiectasia-like disorder; dsb; double strand break; EDTA; ethylenediaminetetraaceti

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2007 سفارش ترجمه

Increased expression and activity of repair genes TDP1 and XPF in non-small cell lung cancer

Keywords: Non-small cell lung cancer; Camptothecin resistance; Topoisomerase I-mediated DNA damage; Oxidative damage; Single-strand-break repair; Double-strand-break repair; Overexpression of repair genes; TDP1; XPF; MUS81

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2007 سفارش ترجمه

ATM, the Mre11/Rad50/Nbs1 complex, and topoisomerase I are concentrated in the nucleus of Purkinje neurons in the juvenile human brain

Keywords: Double-strand breaks; Ataxia telangiectasia; Cerebellum; TDP1; Bergmann glia; Golgi neuron;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2007 سفارش ترجمه

TDP1 facilitates repair of ionizing radiation-induced DNA single-strand breaks

Keywords: TDP1; Single strand break repair; Ionizing radiation; Radiotherapy; XRCC1; Oxidative stress;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2007 سفارش ترجمه