On the Accuracy of Estimation of Basic Pharmacokinetic Parameters by the Traditional Noncompartmental Equations and the Prediction of the Steady-State Volume of Distribution in Obese Patients Based Upon Data Derived from Normal Subjects
Keywords: Steady-state volume of distribution; terminal volume of distribution; mean residence time; central elimination; physiologically based pharmacokinetic model; adipose tissue; tissue-plasma partition coefficient; obese subject; underweight subject;