Keywords: Influenza A virus; AM2 proton channel; AM2-S31N inhibitor; Organosilane; Antiviral; WT; wild type; DMEM; Dulbecco's modified eagle medium; MDCK; Madin-Darby Canine Kidney; TEVC; two-electrode voltage clamps;
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Keywords: Nicotinic acetylcholine receptor; Nocturnal frontal lobe epilepsy; α4β2 isoform; Cytoplasmic loop; nAChR; nicotinic acetylcholine receptor; NFLE; nocturnal frontal lobe epilepsy; ADNFLE; autosomal dominant nocturnal frontal lobe epilepsy; HS; high sensi
Molecular cloning, spatiotemporal and functional expression of GABA receptor subunits RDL1 and RDL2 of the rice stem borer Chilo suppressalis
Keywords: Chilo suppressalis; Electrophysiology; RDL subunits; GABA-gated chloride channel receptor; Spatiotemporal mRNA and heterologous expression; Insecticide actions; ANOVA; analysis of variance; cDNA; complementary DNA; CI; confidence interval; cRNA; capped RN
Functional properties and mechanism of action of PPTQ, an allosteric agonist and low nanomolar positive allosteric modulator at GABAA receptors
Keywords: Ago-PAM; allosteric agonist and positive allosteric modulator; C/R; concentration-response; ECD; extracellular domain; FMP; FLIPR Membrane Potential Blue; GABA; γ-Aminobutyric acid; GABAAR; GABAA receptor; methaqualone; 2-methyl-3-(o-tolyl)-quinazolin-4(
Identification of eugenol as the major determinant of GABAA-receptor activation by aqueous Syzygium aromaticum L. (clove buds) extract
Keywords: Acetyleugenol; Analgesic activity; Clove buds; Eugenol; GABAA receptor; Two-electrode voltage clamp technique; γ-Amino butyric acid; GABA; (ultra) high-performance liquid chromatography; (U)HPLC; gas chromatography; GC; two-electrode voltage clamp; TEVC;
Functional screening for G protein-coupled receptor targets of 14,15-epoxyeicosatrienoic acid
Keywords: 14,15-EET (EET); 14,15-epoxyeicosatrienoic acids; 14,15-EEZE; 14,15-epoxyeicosa-5(Z)-enoic acid; VSMCs; vascular smooth muscle cells; GPCR; G protein-coupled receptor; CFTR; Cystic Fibrosis Transmembrane Conductance Regulator; PKA; Protein Kinase A; PTG;
Functional mapping of the N-terminal arginine cluster and C-terminal acidic residues of Kir6.2 channel fused to a G protein-coupled receptor
Keywords: ACh; acetylcholine; atm; atmosphere; C-ter; C-terminus; CTD; cytoplasmic domain; D2; D2L dopaminergic receptor; GPCR; G protein-coupled receptor; ICCR; ion channel-coupled receptor; N-ter; N-terminus; TEVC; two-electrode voltage-clamp; TMD; transmembrane
Broflanilide: A meta-diamide insecticide with a novel mode of action
Keywords: EBOB; 4â²-ethynyl-4-n-propylbicycloorthobenzoate; GABA; γ-aminobutyric acid; GABAAR; GABA type A receptor; GABAR; GABA receptor; GlyR; glycine receptor; GluCl; glutamate-gated channel; meta-diamides; 3-benzamido-N-(4-(perfluoropropan-2-yl)phenyl)benzami
Assessment of the functionality and stability of detergent purified nAChR from Torpedo using lipidic matrixes and macroscopic electrophysiology
Keywords: nAChR-DCs; nicotinic acetylcholine receptors detergent complexes; Tc; Torpedo californica; Tm; Torpedo marmorata; PLB; planar lipid bilayer; TEVC; two electrode voltage clamp; LCP; Lipidic Cubic Phase; FC; foscholine family 12-16 carbon chain; LFC; lyso
Hydrophobic interactions between the S5 segment and the pore helix stabilizes the closed state of Slo2.1 potassium channels
Keywords: Ic-rel; constitutive Irel; Irel; current normalized to that induced by 6Â mM NFA; ISlo2.1; Slo2.1 current; KNa; Na+-activated K+; Â NFA; niflumic acid; Po; open probability; TEVC; two-electrode voltage clamp; Vt; test voltage; wt; wild-type; Biophysics; P
Proton-dependent glutamine uptake by aphid bacteriocyte amino acid transporter ApGLNT1
Keywords: AAAP; amino acid/auxin permease; APC; amino acid-polyamine-organocation; ApGLNT1; Acyrthosiphon pisum glutamine transporter 1; PAT; proton-dependent amino acid transporter; SLC; solute carrier; TEVC; two-electrode voltage clamp; V-ATPase; vacuolar-typ
Synthesis of photoreactive ivermectin B1a derivatives and their actions on Haemonchus and Bombyx glutamate-gated chloride channels
Keywords: AVM; avermectin; DCC; dicyclohexylcarbodiimide; DIPEA; N,N-diisopropylethylamine; DMAP; 4-(dimethylamino)pyridine; DMF; N,N-dimethylformamide; DMSO; dimethyl sulfoxide; EDC; 1-ethyl-3-(3-dimethylamino-propyl)carbodiimide; GABA; γ-aminobutyric acid; GABAC
Exploration of the molecular architecture of the orthosteric binding site in the α4β2 nicotinic acetylcholine receptor with analogs of 3-(dimethylamino)butyl dimethylcarbamate (DMABC) and 1-(pyridin-3-yl)-1,4-diazepane
Keywords: nACh receptor agonists; Structure-activity studies; Ls-AChBP; Ac-AChBP; Lobeline; DMABC analogs; Ac; Aplysia californica; ACh; acetylcholine; AChBP; acetylcholine binding protein; CNS; central nervous system; CDI; 1,1â²-carbonyldiimidazole; Ct; Capitel
Functional characterization of a transition metal ion transporter, OsZIP6 from rice (Oryza sativa L.)
Keywords: Oryza sativa; OsZIP6; Two-electrode voltage clamp; Transition metal ions; AAS; atomic absorption spectroscopy; CDF; cation diffusion facilitator; ELM; eukaryotic linear motif resource; Km; Michaelis constant; NRAMP; natural resistance associated macrophag
Benzodiazepine modulation of homomeric GABAAÏ1 receptors: Differential effects of diazepam and 4â²-chlorodiazepam
Keywords: GABA; γ-aminobutyric acid; GABAA receptors; GABAARs; BDZs; benzodiazepines; TPMPA; (1,2,5,6-Tetrahydropyridin-4-yl)methylphosphinic acid; TACA; trans-aminocrotonic acid; CACA; cis-aminocrotonic acid; CNS; central nervous system; TEVC; two electrode volta
A hydrophobic residue in position 15 of the rP2X3 receptor slows desensitization and reveals properties beneficial for pharmacological analysis and high-throughput screening
Keywords: P2X3 receptor; Desensitization; Mechanism of antagonism; Drug screening; Calcium imaging; αÃ-meATP; αÃ-methylene-ATP; CI; confidence interval; EC50; 50% effective concentration; IC50; 50% inhibitory concentration; Ki; inhibition constant; pA2; negativ
Tissue-Specific Amino Acid Transporter Partners ACE2 and Collectrin Differentially Interact With Hartnup Mutations
Keywords: ACE; angiotensin-converting enzyme; SNP; single nucleotide polymorphism; TEVC; 2-electrode voltage clamp;
Memantine does not show intracellular block of the NMDA receptor channel
Keywords: Memantine; N-methyl-d-aspartate (NMDA); Patch clamp; TEVC; Inside-out patches; Xenopus oocytes; NR1a/2A; Uncompetitive antagonist; Kinetics; Voltage-dependency
Fluctuations in Xenopus oocytes protein phosphorylation levels during two-electrode voltage clamp measurements
Keywords: TEVC; Current fluctuations; Ion channels; Phosphorylation; Protein kinases; Protein phosphatases; PKA;