
Keywords: تیوکلچیسین; Drug design; Microtubules; Microtubule-binding agents; Thiocolchicine; Tubulin structure; MT; Microtubules; MTBCs; MT-targeting bivalent compounds; MDA; microtubule depolymerizing agent; MSA; microtubule stabilizing agent; TH; thiocolchicine; THdim-S; sho