Keywords: مهار وابسته به زمان; AIDS; acquired immunodeficiency syndrome; AUC; area under the plasma concentration versus time curve of NVP in absence of NT; AUCI; area under the plasma concentration versus time curve of NVP in presence of NT; AUCratio; ratio between AUCI and AUC (AUCI/
مقالات ISI مهار وابسته به زمان (ترجمه نشده)
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Keywords: مهار وابسته به زمان; ESI; electrospray ionization; LC-MS; liquid chromatography-mass spectrometry; MtSK; Mycobacterium tuberculosis shikimate kinase; LDH; lactate dehygrogenase; PK; pyruvate kinase; MtKatG; Mycobacterium tuberculosis catalase peroxidase; IQ; ilimaquinone; NAD
Keywords: مهار وابسته به زمان; plasma protein binding; fraction unbound; drug-drug interaction; AUC; area under the curve; AUCR; area under the curve ratio; AAG; alpha 1-acid glycoprotein; CYP; cytochrome P450; BSA; bovine serum albumin; CRO; contract research organization; CV; coeffic
Keywords: مهار وابسته به زمان; Structure–kinetic relationship; Kinetic efficiency; ERK2; Time-dependent inhibition; Off-rate; Residence time
Derivation of CYP3A4 and CYP2B6 degradation rate constants in primary human hepatocytes: A siRNA-silencing-based approach
Keywords: مهار وابسته به زمان; Cytochrome P450; Drug-drug interactions; Degradation rate constant; Human hepatocytes; Mechanism-based inhibition; Physiologically-based pharmacokinetic modelling; Small-interfering RNA; Half-life; Time-dependent inhibition;
Kinetic mechanism of time-dependent inhibition of CYP2D6 by 3,4-methylenedioxymethamphetamine (MDMA): Functional heterogeneity of the enzyme and the reversibility of its inactivation
Keywords: مهار وابسته به زمان; Cytochrome P450 2D6; Methylenedioxyphenyl compounds; Time-dependent inhibition; 3,4-methylenedioxymethamphetamine; Mechanism-based inhibition;
Bush mint (Hyptis suaveolens) and spreading hogweed (Boerhavia diffusa) medicinal plant extracts differentially affect activities of CYP1A2, CYP2D6 and CYP3A4 enzymes
Keywords: مهار وابسته به زمان; CYP450; Herb-drug interaction; Time-dependent inhibition; Ki; Hyptis suaveolens; Boerhavia diffusa; Flourimetric assay; Medicinal herb; Polyphenolic compounds; UPLC-MS;
Inhibition of Cytochrome P450 by Nomilin and Obacunone and Potential Mechanism in Human Liver Microsomes
Keywords: مهار وابسته به زمان; cytochrome P450; human liver microsomes; limonoids; nomilin; obacunone; time-dependent inhibition;
Apigenin, a novel candidate involving herb-drug interaction (HDI), interacts with organic anion transporter 1 (OAT1)
Keywords: مهار وابسته به زمان; HDI; herb-drug interaction; OAT1; organic anion transporter 1; TDI; time-dependent inhibition; Apigenin; MDCK-OAT1 cells; TDI; Acyclovir; Adefovir; HDI;
Development and validation of an in vitro, seven-in-one human cytochrome P450 assay for evaluation of both direct and time-dependent inhibition
Keywords: مهار وابسته به زمان; Cytochrome P450; Drug–drug interactions; N-in-one; Time-dependent inhibition; Single point inactivation; Methods
Variation in the inhibitory potency of terbinafine among genetic variants of CYP2D6
Keywords: مهار وابسته به زمان; Drug interactions; Time-dependent inhibition; Interindividual variation; Personalized medication
Discovery and optimization of a highly efficacious class of 5-aryl-2-aminopyridines as FMS-like tyrosine kinase 3 (FLT3) inhibitors
Keywords: مهار وابسته به زمان; Feline McDonough sarcoma (FMS)-like tyrosine kinase 3 (FLT3); Aminopyridine; Hinge binding motif; CYP3A4; Time-dependent inhibition
Optimization of a novel series of N-phenylindoline-5-sulfonamide-based acyl CoA:monoacylglycerol acyltransferase-2 inhibitors: Mitigation of CYP3A4 time-dependent inhibition and phototoxic liabilities
Keywords: مهار وابسته به زمان; ACAT; acyl CoA:cholesterol acyltransferase; ADME; absorption, distribution, metabolism and excretion; APCI; atomospheric pressure chemical ionization; CM; chylomicron; dba; dibenzylideneacetone; CYP; cytochrome P450; DDI; drug-drug interaction; DGAT; ac
Inhibitory effects of sanguinarine on human liver cytochrome P450 enzymes
Keywords: مهار وابسته به زمان; Sanguinarine; Human liver microsomes; Cytochrome P450 enzyme; Drug-drug interaction; Time-dependent inhibition;
Design, synthesis, modeling, biological evaluation and photoaffinity labeling studies of novel series of photoreactive benzamide probes for histone deacetylase 2
Keywords: مهار وابسته به زمان; Benzamides; HDAC 1 and 2; Time-dependent inhibition; Photoaffinity labeling; Diazides
High-performance liquid chromatography-tandem mass spectrometry assay of fatty acid amide hydrolase (FAAH) in blood: FAAH inhibition as clinical biomarker
Keywords: مهار وابسته به زمان; Fatty acid amide hydrolase (FAAH); Enzyme activity assay; Anandamide; Arachidonoylethanolamide; Radiometric; HPLC-MS/MS; Bioanalytical; Biomarkers; Time-dependent inhibition;
Time-dependent botulinum neurotoxin serotype A metalloprotease inhibitors
Keywords: مهار وابسته به زمان; Botulinum neurotoxin serotype A; Benzimidazole acrylonitrile; Structure-activity relationships; Molecular modeling; Time-dependent inhibition;
Time-dependent slowly-reversible inhibition of monoamine oxidase A by N-substituted 1,2,3,6-tetrahydropyridines
Keywords: مهار وابسته به زمان; YIOOFSFSYIFVGA-UHFFFAOYSA-N; RFGSGIYDYZAVKP-UHFFFAOYSA-N; PATARMBKZNQOFI-UHFFFAOYSA-N; ZCNRONWKKLYGKC-UHFFFAOYSA-N; WOKZGPAOFQHBRB-UHFFFAOYSA-N; QUOQRHUEAFIBQT-UHFFFAOYSA-N; PEWKBQSNFNCVBM-UHFFFAOYSA-N; SIRJFTFGHZXRRZ-UHFFFAOYSA-N; NLNNODLEXBFJDM-UHFFFAOY
Addressing time-dependent CYP 3A4 inhibition observed in a novel series of substituted amino propanamide renin inhibitors, a case study
Keywords: مهار وابسته به زمان; CYP3A4; Time-dependent inhibition; Renin; Hypertension
Influence of ligand binding kinetics on functional inhibition of human recombinant serotonin and norepinephrine transporters
Keywords: مهار وابسته به زمان; Binding kinetics; LeuT; Mode of inhibition; Monoamine reuptake inhibitor; NET; Neurotransmitter uptake methods; SERT; SLC6 transporter; Time-dependent inhibition
Design, synthesis, and evaluation of trifluoromethyl ketones as inhibitors of SARS-CoV 3CL protease
Keywords: مهار وابسته به زمان; SARS; Protease inhibitor; Trifluoromethyl ketone; Time-dependent inhibition