Keywords: TM، فرابنفش; SV, synaptic vesicles; PM, presynaptic membrane; α-BTX, alpha-bungarotoxin; Syt, synaptotagmin; TM, transmembrane; NMJ, neuromuscular junction; JMS, juxtamembrane segment; h-JMS, hexyl juxtamembrane segment; h-sJMS, hexyl scrambled juxtamembrane segment;
مقالات ISI TM، فرابنفش (ترجمه نشده)
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Keywords: TM، فرابنفش; TM, transmembrane; TMH, transmembrane helix; AP, arrest peptide; bR, bacteriorhodopsin; MP, membrane protein; ER, endoplasmic reticulum; MD, molecular dynamics; AFM, atomic force microscopy; PTC, polypeptide transferase center; SRP, signal recognition par
Prediction and characterization of P-glycoprotein substrates potentially bound to different sites by emerging chemical pattern and hierarchical cluster analysis
Keywords: TM، فرابنفش; P-gp, P-glycoprotein; ABC, ATP-binding cassette; MDR, multidrug resistance; EP, emerging pattern; ECP, emerging chemical pattern; ECPG, emerging chemical pattern group; TM, transmembrane; TMD, transmembrane domain; NBD, nucleotide-binding domain; SBS, sub
Functional importance of the Gly cluster in transmembrane helix 2 of the Bordetella pertussis CyaA-hemolysin: Implications for toxin oligomerization and pore formation
Keywords: TM، فرابنفش; Adenylate cyclase-hemolysin; GXXGXXXG motif; Helix–helix association; Hemolytic activity; Trimeric pore modelCyaA, adenylate cyclase-hemolysin toxin; CyaA-Hly, CyaA-hemolysin domain; PFT, pore-forming toxin; RTX, Repeats-in-ToXin; TM, transmembrane
The AQP2 mutation V71M causes nephrogenic diabetes insipidus in humans but does not impair the function of a bacterial homolog
Keywords: TM، فرابنفش; AQP, aquaporin; AVP, arginine vasopressin; AVPR2, V2 receptor; AQP ER, endoplasmic reticulum; GlpF, glycerol facilitator; GpA, glycophorin A; HM, half-membrane-spanning; NDI, nephrogenic diabetes insipidus; TM, transmembrane; wt, wild-typeGlpF; Aquaporin;
ChBax/Bak as key regulators of the mitochondrial apoptotic pathway: Cloned and characterized in Crassostrea hongkongensis
Keywords: TM، فرابنفش; Crassostrea hongkongensis; Mitochondrial pathway; ChBax; ChBakHIV-1, human immunodeficiency virus-1; MOMP, mitochondrial outer membrane permeabilization; IMS, inter-membrane space; TM, transmembrane; ORF, open reading frame; UTR, untranslated region; Bcl2
Two iron-regulated transporter (IRT) genes showed differential expression in poplar trees under iron or zinc deficiency
Keywords: TM، فرابنفش; IRT, iron regulated transporter; ZIP, zinc-regulated transporter, iron-regulated transporter-like protein; TM, transmembrane; qPCR, quantitative real-time PCR; FRO, ferric reductase oxidase; BLASTP, basic local alignment search tool using protein query; O
Discovery, synthesis and biological evaluation of 2-(4-(N-phenethylsulfamoyl)phenoxy)acetamides (SAPAs) as novel sphingomyelin synthase 1 inhibitors
Keywords: TM، فرابنفش; SM, sphingomyelin; SMS, sphingomyelin synthase; PC, phosphatidylcholine; DAG, diacylglycerol; TM, transmembrane; hSMS1, human sphingomyelin synthase 1; His, histidine; Asp, aspartic acid; SAPA, 2-(4-(N-phenethylsulfamoyl)phenoxy)acetamide; SAR, structure–
SecA Drives Transmembrane Insertion of RodZ, an Unusual Single-Span Membrane Protein
Keywords: TM، فرابنفش; S-SMP, single-span membrane protein; TM, transmembrane; MP, membrane protein; PMF, proton motive force; SRP, signal recognition particle; protK, proteinase K; CCCP, carbonyl cyanide m-chlorophenyl hydrazone; BTX, α-bungarotoxin; MBP, maltose binding prote
Purinergic P2X receptors: Structural models and analysis of ligand-target interaction
Keywords: TM، فرابنفش; Molecular modelling; Nucleotides; Purinergic receptors; P2X receptor agonists; P2X receptor antagonists; P2X receptorsATP, adenosine-5′-triphosphate; TM, transmembrane; αβ-meATP, alpha,beta-methylene-ATP; βγ-meATP, beta,gamma-methylene-ATP; ATPγS, adenosi
Michael acceptor approach to the design of new salvinorin A-based high affinity ligands for the kappa-opioid receptor
Keywords: TM، فرابنفش; Salvinorin A and B; Michael acceptor-type ligands; Kappa, delta, and mu opioid receptors; Molecular modelingDOR, δ-opioid receptor; GPCR, G protein-coupled receptor; KOR, κ-opioid receptor; MOR, μ-opioid receptor; TM, transmembrane; PDB, protein data bank
Inactivation of Omi/HtrA2 protease leads to the deregulation of mitochondrial Mulan E3 ubiquitin ligase and increased mitophagy
Keywords: TM، فرابنفش; mnd2, motor neuron degeneration 2; HtrA2, High temperature requirement protein A2; PQC, protein quality control; UPS, ubiquitin–proteasome system; TM, transmembrane; IMM, inner mitochondrial membrane; OMM, mitochondrial membrane; IMS, inter-membrane space
A new ATP7B gene mutation with severe condition in two unrelated Iranian families with Wilson disease
Keywords: TM، فرابنفش; WD, Wilson disease; KF, Kayser–Fleischer; TM, transmembrane; OMIM, Online Mendelian Inheritance in Man; ATP7B, gene of copper-transporting p-type 2 ATPase; DHPLC, Denaturing High-Performance Liquid Chromatography; CT, computed tomography; MRI, magnetic re
Molecular cloning and the expression of the Na+/H+antiporter in the monocot halophyte Leptochloa fusca (L.) Kunth
Keywords: TM، فرابنفش; NHX, vacuolar Na+/H+ antiporter; ORF, open reading frame; RACE, rapid amplification of cDNA ends; TM, transmembrane; UTR, untranslated regionHalophyte; Leptochloa fusca; Salt tolerance; Vacuolar Na+/H+ antiporter
Overexpression of inactive tetherin delGPI mutant inhibits HIV-1 Vpu-mediated antagonism of endogenous tetherin
Keywords: TM، فرابنفش; HIV-1, human immunodeficiency virus type 1; TM, transmembrane; GPI, glycosylphosphatidylinositol; delGPI, GPI deleted; AGM, African green monkey; mab, monoclonal antibody; AME, Amphotericin B methyl esterHIV-1; Tetherin; Vpu; Overexpression
RAET1/ULBP alleles and haplotypes among Kolla South American Indians
Keywords: TM، فرابنفش; HLA, human leukocyte antigen; MICA/B, MHC class I-related chain A/B; AF, allele frequency; RAET1, retinoic acid early transcription 1; ULBP, UL-16 binding protein; NKG2D, natural killer group 2 member D; TM, transmembrane; GPI, glycophosphatidylinositol;
Effects of transmembrane region variability on cell surface expression and allorecognition of HLA-DP3
Keywords: TM، فرابنفش; HSCT, hematopoietic stem cell transplantation; VUD, volunteer unrelated donors; GvHD, graft versus host disease; TM, transmembrane; PCR-SSP, PCR-sequence specific priming; BLCL, Epstein–Barr Virus transformed B lymphoblastoid cell lines; MLR, mixed lympho
Breaking the barriers in membrane protein crystallography
Keywords: TM، فرابنفش; CPM, N-[4-(7-diethylamino-4-methyl-3-coumarinyl)phenyl]-maleimide; GPCR, G-protein coupled receptor; TM, transmembrane; FSEC, fluorescence-detection size-exclusion chromatography; DDM, dodecyl-β-d-maltopyranoside; FC-12, Fos-Choline-12; β1-AR, β1-adrenerg
Effects of a polar amino acid substitution on helix formation and aggregate size along the detergent-induced peptide folding pathway
Keywords: TM، فرابنفش; ANS, 1-anilino-8-naphthalene sulfonate; AI5, model transmembrane peptide without a central polar insert; DPC, n-dodecyl phosphatidylcholine; I12N, model transmembrane peptide with a central polar insert; TM, transmembrane; SDS, sodium dodecylsulfate; CMC,
Charge Pair Interactions in Transmembrane Helices and Turn Propensity of the Connecting Sequence Promote Helical Hairpin Insertion
Keywords: TM، فرابنفش; Ct, C-terminus; ER, endoplasmic reticulum; Lep, leader peptidase; RM, rough microsomal membrane; PV, poliovirus; TM, transmembrane; OST, oligosaccharyl transferaseelectrostatic interactions; helical hairpin; membrane integration; salt bridge; translocon
Conformational Flexibility and Structural Dynamics in GPCR-Mediated G Protein Activation: A Perspective
Keywords: TM، فرابنفش; GPCR, G protein coupled receptor; MD, molecular dynamics; DEER, double electron–electron resonance; TM, transmembrane; NMA, normal mode analysis; Meta, metarhodopsin; CT, C terminus; myr, myristoylationGα; hydrophobic triad; IC2; β2/β3 loop; conformationa
A conserved interdomain communication pathway of pseudosymmetrically distributed residues affects substrate specificity of the fungal multidrug transporter Cdr1p
Keywords: TM، فرابنفش; MDR, multidrug resistance; PDR, pleiotropic drug resistance; ABC, ATP-binding cassette; NBD, nucleotide binding domain; TMD, transmembrane domain; TM, transmembrane; SCA, statistical coupling analysis; 4-NQO, 4-nitroquinoline 1-oxide; DiOC6, 3,3′-dihexylo
Spatial distribution of cytoplasmic domains of the Mg2+-transporter MgtE, in a solution lacking Mg2+, revealed by paramagnetic relaxation enhancement
Keywords: TM، فرابنفش; PRE, paramagnetic relaxation enhancement; TM, transmembrane; MgtECP, cytoplasmic region of MgtE (residues 1–259); HEPES, 4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid; MTSL, S-(2,2,5,5-tetramethyl-2,5-dihydro-1H-pyrrol-3-yl)methyl methanesulfonothioa
PEDV ORF3 encodes an ion channel protein and regulates virus production
Keywords: TM، فرابنفش; PEDV, porcine epidemic diarrhea virus; ORF, open reading frame; TGEV, transmissible gastroenteritis virus; ORi, oocyte Ringer’s-like solution; TEVC, two electrode voltage clamp; TM, transmembrane; TMD, transmembrane domain; MD, molecular dynamics; sgRNA,
Molecular basis for sculpting the endoplasmic reticulum membrane
Keywords: TM، فرابنفش; ER, endoplasmic reticulum; NE, nuclear envelope; OSER, organized smooth ER; ATL, atlastin; RHD3, Root Hair Defective 3; HSP, hereditary spastic paraplegia; TM, transmembrane; CT, C-terminal tail; ONM, outer nuclear membrane; INM, inner nuclear membrane; L
Dynamics of Klebsiella pneumoniae OmpA transmembrane domain: The four extracellular loops display restricted motion behavior in micelles and in lipid bilayers
Keywords: TM، فرابنفش; KpOmpA, Klebsiella pneumoniae outer membrane protein A; TM, transmembrane; LPR, lipid to protein ratio; CMC, critical micellar concentration; PLE, E. coli Polar Lipid Extract; OG, n-octyl-β-d-glucopyranoside; DHPC, 1,2-dihexanoyl-sn-glycero-3-phosphocholi
Structural and thermodynamic insight into the process of “weak” dimerization of the ErbB4 transmembrane domain by solution NMR
Keywords: TM، فرابنفش; ErbB, epidermal growth factor receptor; TM, transmembrane; NOE, nuclear Overhauser effect; NOESY, NOE spectroscopy; MHP, molecular hydrophobicity potential; DMPC, dimyristoylphosphatidylcholine; DHPC, dihexanoylphosphatidylcholineReceptor tyrosine kinase;
Conserved residues in the aromatic acid/H+ symporter family are important for benzoate uptake by NCgl2325 in Corynebacterium glutamicum
Keywords: TM، فرابنفش; Benzoate; Corynebacterium glutamicum; NCgl2325; Site-directed mutagenesis; TransporterMFS, major facilitator superfamily; AAHS, aromatic acid/H+ symporter; TM, transmembrane
Spatial structure and dimer–monomer equilibrium of the ErbB3 transmembrane domain in DPC micelles
Keywords: TM، فرابنفش; TM, transmembrane; DPC, dodecylphosphocholine; tm, isolated transmembrane domain; RTK, receptor tyrosine kinase; LDAO, Lauryldimethylamine-oxide; FRET, Foerster resonance energy transfer; TFE, trifluoroethanol; TFA, trifluoroacetic acid; NOE, nuclear Over
Lipid-Controlled Peptide Topology and Interactions in Bilayers: Structural Insights into the Synergistic Enhancement of the Antimicrobial Activities of PGLa and Magainin 2
Keywords: TM، فرابنفش; TM, transmembrane; CP, cross-polarization; di-C10:0-PC, 1,2-didecanoyl-sn-glycero-3-phosphocholine; di-C12:0-PC, 1,2-dilaureoyl-sn-glycero-3-phosphocholine; di-C20:1-PC, 1,2-dieicosenoyl-sn-glycero-3-phosphocholine; DMPC, 1,2-dimyristoyl-sn-glycero-3-phos
Role of Bundle Helices in a Regulatory Crosstalk in the Trimeric Betaine Transporter BetP
Keywords: TM، فرابنفش; BCCT, betaine–choline–carnitine transporter; PDB, Protein Data Bank; TM, transmembrane; WT, wild type; TCEP, tris(2-carboxyethyl)phosphine; DDM, β-dodecyl-maltosidealternating access; betaine transport; inverted repeats; Na+ coupling; transport activity r
A mutant residue in the third transmembrane region of the GABAA alpha1 subunit causes increased agonistic neurosteroid responses
Keywords: TM، فرابنفش; TM, transmembrane; ALLO, allopregnanolone, 3α derivatives, such as 3α-hydroxy-5α-pregnan-20-one; THDOC, tetrahydroxycorticosterone, 3α,21-hydroxy-5α-pregnan-20-one; CFFR, calcium free frog Ringer's; pCMBS−, para-chloromercuribenzenesulfonic acid; P4S, pip
Characterization of ovine Toll-like receptor 9 protein coding region, comparative analysis, detection of mutations and maedi visna infection
Keywords: TM، فرابنفش; TLR, Toll-like receptor; ODN, oligodeoxynucleotides; MVV, maedi visna virus; ECD, ectodomain; TM, transmembrane; TIR, Toll/interleukin-1 receptor; LRR, leucine-rich region; OR, Odd's ratio; CI, confidence intervalTLR9; Maedi visna virus; Mutation; Substit
Improving the Resistance of a Eukaryotic β-Barrel Protein to Thermal and Chemical Perturbations
Keywords: TM، فرابنفش; TM, transmembrane; hTom40A, human Tom40A; AfTom40, Tom40 from Aspergillus fumigatus; LDAO, lauryldimethylamine-oxide; GnHCl, guanidine hydrochloride; wt, wild type; IB, inclusion bodiesβ-barrel; Tom40; apparent protein stability; protein engineering; TOM
High-Throughput Selection of Transmembrane Sequences That Enhance Receptor Tyrosine Kinase Activation
Keywords: TM، فرابنفش; SDS PAGE; high-throughput screening; receptor tyrosine kinase; neu; RTK activationRTK, receptor tyrosine kinase; TM, transmembrane; GpA, glycophorin A; CHO, Chinese hamster ovary
The Scope of Phage Display for Membrane Proteins
Keywords: TM، فرابنفش; TM, transmembrane; MP, membrane protein; ORF, open reading frame; BSA, bovine serum albumin; NFM, non-fat milk; PTRF, polymerase I and transcript release factor; PBS, phosphate-buffered saline; RT, room temperature; HIV, human immunodeficiency virusphage
Membrane Insertion and Topology of the Translocating Chain-Associating Membrane Protein (TRAM)
Keywords: TM، فرابنفش; OST, oligosaccharyl transferase; RM, rough microsomes; RNC, ribosome-nascent chain; SRP, signal recognition particle; TM, transmembrane; TRAM, translocating chain-associating membrane; ER, endoplasmic reticulum; TMHMM, transmembrane hidden Markov modelmem
SDS-Facilitated In vitro Formation of a Transmembrane B-Type Cytochrome Is Mediated by Changes in Local pH
Keywords: TM، فرابنفش; assembly; cytochrome; heme; membrane protein folding; two-stage modelDDM, n-dodecyl-β-maltoside; PCA, principal component analysis; MalE, maltose binding protein; TM, transmembrane; 1D, one-dimensional
Roles of Carboxyl Groups in the Transmembrane Insertion of Peptides
Keywords: TM، فرابنفش; TM, transmembrane; wt, wild type; POPC, 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine; OCD, oriented circular dichroism; PEG, polyethylene glycol; pH, extracellular pHmembrane protein folding; pHLIP; pH trigger; carboxyl titration; transmembrane helix
Structural Asymmetry in a Trimeric Na+/Betaine Symporter, BetP, from Corynebacterium glutamicum
Keywords: TM، فرابنفش; 3D, three-dimensional; 2D, two-dimensional; NCS, noncrystallographic symmetry; EM, electron microscopy; LPR, lipid/protein ratio; TM, transmembrane; L-CC, Laplacian-filtered correlation coefficient; CC, cross-correlation coefficient; PDB, Protein Data Ban
A Photon-Free Approach to Transmembrane Protein Structure Determination
Keywords: TM، فرابنفش; PDB, Protein Data Bank; TM, transmembrane; MCSA, Monte Carlo/simulated annealing; RBS, rigid-body sampling; PI, pertubility indexcorrelation analysis; cross-linking; TOXCAT; M2; molecular modeling
The Alternating-Access Mechanism of MFS Transporters Arises from Inverted-Topology Repeats
Keywords: TM، فرابنفش; symmetry; outward-facing conformation; structural modeling; lactose permease; homology modelLacY, lactose permease; MFS, major facilitator superfamily; TM, transmembrane; EAAT, excitatory amino acid transporter; DEER, double electron–electron resonance; N
Fluidizing the Membrane by a Local Anesthetic: Phenylethanol Affects Membrane Protein Oligomerization
Keywords: TM، فرابنفش; anesthetic; glycophorin A; helix–helix interaction; membrane; TOXCATPEtOH, phenylethanol; TM, transmembrane; GpA, glycophorin A; FRET, fluorescence resonance energy transfer; Fl, fluorescein; TAMRA, 5-carboxytetramethylrhodamine; diC(20:1) PC, 1,2-dieicos
Partitioning, dynamics, and orientation of lung surfactant peptide KL4 in phospholipid bilayers
Keywords: TM، فرابنفش; SP-B, surfactant protein B; RDS, respiratory distress syndrome; TM, transmembrane; NMR, nuclear magnetic resonance; CD, circular dichroism; FTIR, Fourier transform infrared spectroscopy; MLV, multilamellar vesicle; LUV, large unilamellar vesicle; Lα, flui
Characterization of ovine TLR7 and TLR8 protein coding regions, detection of mutations and Maedi Visna virus infection
Keywords: TM، فرابنفش; TLR, Toll-like receptors; OR, Odd's ratio; LRR, leucine rich repeats; MV, Maedi Visna; SRLV, small ruminant lentivirus; nBLAST, nucleotide BLAST; ECD, ectodomain; TM, transmembrane; TIR, Toll/interleukin-1 receptor; PAMP, pathogen associated molecular pat
The membrane environment modulates self-association of the human GpA TM domain—Implications for membrane protein folding and transmembrane signaling
Keywords: TM، فرابنفش; GpA, human glycophorin A residues 69–101; TM, transmembrane; FRET, Förster resonance energy transfer; Fl, carboxyfluorescein; TAMRA, 5- (and 6)-carboxytetramethylrhodamine; PC, phosphatidylcholine; DMPC, 1,2-dimyristoyl-sn-glycero-3-phosphocholine; DDM, n
The enigma of the CLIC proteins: Ion channels, redox proteins, enzymes, scaffolding proteins?
Keywords: TM، فرابنفش; CLIC, chloride intracellular channel; GST, glutathione S-transferase; GSH, glutathione; GSTO, GST omega; TM, transmembrane; Grx, glutaredoxin; ERM, ezrin–moesin–radixin; DHAR, dehydroascorbate reductase; ER, endoplasmic reticulumChloride intracellular cha
Lipid-Modulated Sequence-Specific Association of Glycophorin A in Membranes
Keywords: TM، فرابنفش; GpA, Glycophorin A; TM, transmembrane; CG, coarse-grain; DPPC, di-palmitoyl phosphatidylcholine; DOPC, di-oleoyl phosphatidylcholine; DLPC, di-lauroyl phosphatidylcholine; PO4,, phosphate group; GLY, glycerol group; PMF, potential of mean force; RC, react
Genomic assessment of the evolution of the prion protein gene family in vertebrates
Keywords: TM، فرابنفش; CJD, Creutzfedlt-Jakob disease; BSE, bovine spongiform encepahalopathy; TSE, transmissible spongiform encephalopathy; PrP, prion protein; NMR, nuclear magnetic resonance; CNS, central nervous system; TM, transmembrane; PrP-GF, PrP gene family; GPI, glycos
Mutagenesis of human neuropeptide Y/peptide YY receptor Y2 reveals additional differences to Y1 in interactions with highly conserved ligand positions
Keywords: TM، فرابنفش; WT, wild-type; NPY, neuropeptide Y; PYY, peptide YY; PP, pancreatic polypeptide; [125I]pPYY, iodinated porcine PYY; GPCR, G-protein coupled receptor; h, human; p, porcine; TM, transmembrane; hβ2AR, human β2 andrenergic receptor; tβ1AR, turkey β1 andrenerg