Probing the evolutionary conserved residues Y204, F259, S400 and W590 that shape the catalytic groove of human TDP1 for 3â²- and 5â²-phosphodiester-DNA bond cleavage
Keywords: hTDP1; human tyrosyl-DNA phosphodiesterase 1; TOP1; topoisomerase I; TOP2; topoisomerase II; TOP1cc; TOP1 cleavage complex; TOP2cc; TOP2 cleavage complex; DNA damage and repair; 3â²-End blocking DNA lesions; 5â²-End blocking DNA lesions; Topoisomerases;