Structural determinants of the catalytic inhibition of human topoisomerase IIα by salicylate analogs and salicylate-based drugs
Keywords: topo II، topoisomerase II; 2-FBA, 2-fluorobenzoate; 2-MBA, 2-methylbenzoate; 5-ASA, 5-aminosalicylic acid; ASA, acetylsalicylic acid; DHBA, dihydroxybenzoate; HBA, hydroxybenzoate; ICE, in vivo complex of enzyme; kDNA, kinetoplast DNA; topo II, topoisomerase II; THBA, trihydroxyben