دانلود مقالات ISI درباره ترخیص کامل بدن + ترجمه فارسی

Pharmacokinetics, tissue distribution and excretion of luteolin and its major metabolites in rats: Metabolites predominate in blood, tissues and are mainly excreted via bile

Keywords: ترخیص کامل بدن; Luteolin; Metabolite; Pharmacokinetics; Bioavailability; Distribution; Excretion; ADME; absorption, distribution, metabolism and excretion; AUC; area under the curve; BCRP; breast cancer resistance protein; CE; collision energy; Cmax; peak concentration;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2017 سفارش ترجمه

Pharmacokinetics of human recombinant C1-esterase inhibitor and development of anti-drug antibodies in healthy dogs

Keywords: ترخیص کامل بدن; AUC; area under the curve; AUClast; area under the plasma concentration-time curve from the time of dosing to the last measurable (positive) concentration; AUC-INFobs; area under the plasma concentration-time curve from the time of dosing extrapolated to

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2018 سفارش ترجمه

In vivo and in vitro diclofenac 5-hydroxylation mediated primarily by cytochrome P450 3A enzymes in common marmoset livers genotyped for P450 2C19 variants

Keywords: ترخیص کامل بدن; AUC; area under the plasma concentration vs. time curve; CL; total body clearance; P450; general term for cytochrome P450 (EC 1.14.14.1); V; volume of distribution; Marmoset; CYP3A4; CYP2C19; Polymorphism; PBPK;

دانلود رایگان متن کامل مقاله ISI 18 صفحه سال انتشار : 2018 سفارش ترجمه

A systematic review of pharmacokinetic studies on herbal drug Fuzi: Implications for Fuzi as personalized medicine

Keywords: ترخیص کامل بدن; Aconitum carmichaeli Debx.; Aconitum alkaloids; Pharmacokinetics; Herb-drug interactions; Toxicology; Personalized medicine; DMEs; drug-metabolizing enzymes; ETs; efflux transporters; BB; bioavailability barrier; DDAs; diester-diterpene alkaloids; MDAs; m

دانلود رایگان متن کامل مقاله ISI 55 صفحه سال انتشار : 2018 سفارش ترجمه

Prediction of human percutaneous absorption from in vitro and in vivo animal experiments

Keywords: ترخیص کامل بدن; PK; pharmacokinetic; Vd; steady-state volume of distribution; CL; total body clearance; OECD; the Organization for Economic Co-operation and Development; FDA; U.S. Food and Drug Administration; EMA; European Medicines Agency; IV; intravenous; LC-MS/MS;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2017 سفارش ترجمه

A PEGylated analog of short-length Neuromedin U with potent anorectic and anti-obesity effects

Keywords: ترخیص کامل بدن; Neuromedin U (NMU); NMU-8; Polyethylene glycol (PEG); Diabetes; Obesity; NMU; neuromedin U; PEG; polyethyleneglycol; PipAc; 2-(piperazin-1-yl)acetic acid; CNS; central nervous system; DIO; diet-induced obesity; EMCS; N-(6-maleimidocaproyloxy)succinimide;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2017 سفارش ترجمه

Discovery of Novel and Potent Stearoyl Coenzyme A Desaturase 1 (SCD1) Inhibitors as Anticancer Agents

Keywords: ترخیص کامل بدن; Ac; acetyl; ADME; absorption, distribution, metabolism, and excretion; aq.; aqueous; AUC; total area under the blood concentration-time curve; bid; bis in die (twice per day); Boc; (tert-butoxy)carbonyl; Bu; butyl; Bz; benzoyl; cLogP; calculate logarith

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2017 سفارش ترجمه

Simulations of Cytochrome P450 3A4-Mediated Drug-Drug Interactions by Simple Two-Compartment Model-Assisted Static Method

Keywords: ترخیص کامل بدن; bioavailability; cytochrome P450; drug interaction; dynamic simulation; first pass metabolism; hepatic clearance; intestinal metabolism; pharmacokinetics; simulations; parallel tube model; Ae (Ae,oral); dose fractions of urinary excreted unchanged drug af

دانلود رایگان متن کامل مقاله ISI 39 صفحه سال انتشار : 2017 سفارش ترجمه

Quantitative Analyses of the Influence of Parameters Governing Rate-Determining Process of Hepatic Elimination of Drugs on the Magnitudes of Drug-Drug Interactions via Hepatic OATPs and CYP3A Using Physiologically Based Pharmacokinetic Models

Keywords: ترخیص کامل بدن; cytochrome P450; drug interaction; hepatic clearance; mathematical model; organic anion-transporting polypeptide transporters; pharmacokinetics; AUC; area under the plasma concentration-time curve; CL; clearance; CLint,all; overall hepatic intrinsic cle

دانلود رایگان متن کامل مقاله ISI 55 صفحه سال انتشار : 2017 سفارش ترجمه

Slow R-warfarin 7-hydroxylation mediated by P450 2C19 genetic variants in cynomolgus monkeys in vivo

Keywords: ترخیص کامل بدن; AUC; area under the plasma concentration vs. time curve; CL; total body clearance; P450; general term for cytochrome P450 (EC 1.14.14.1); t1/2; elimination half-life; V; volume of distribution; Cynomolgus monkey; CYP2C19; Genotyping; Stereoselectivity; S-

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2015 سفارش ترجمه

Preclinical pharmacokinetic and toxicological evaluation of MIF-1 peptidomimetic, PAOPA: Examining the pharmacology of a selective dopamine D2 receptor allosteric modulator for the treatment of schizophrenia

Keywords: ترخیص کامل بدن; 5-HT2; 5-hydroxytryptamine; 6-OHDA; 6-hydroxydopamine; AM; allosteric modulator; AUC; area under curve; AUCINF; area under curve extrapolated to infinity; AUClast; area under curve from dosing to observation; AUMC; area under first moment curve; CL; total

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2013 سفارش ترجمه

Conceptual underestimation of the total body clearance by the sum of clearances of individual organs in physiologically based pharmacokinetics

Keywords: ترخیص کامل بدن; total body clearance; hepatic clearance; physiological model; lung metabolism; distribution; elimination; venous blood; arterial blood;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2012 سفارش ترجمه

Indocyanine green clearance varies as a function of N-acetylcysteine treatment in a murine model of acetaminophen toxicity

Keywords: ترخیص کامل بدن; ALT; alanine aminotransferase; APAP; acetaminophen, paracetamol, N-acetyl-p-aminophenol; AST; aspartate aminotransferase; AUC; area under the curve; AUC0-∞; AUC to infinity; ClT; total body clearance; Cn; final plasma concentration; λz; apparent term

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2011 سفارش ترجمه

Pharmacokinetic studies of scorpion venom before and after antivenom immunotherapy

Keywords: ترخیص کامل بدن; Scorpion; Androctonus australis; Venom; Pharmacokinetics; Antivenom; Immunotherapy; Aag; Androctonus australis garzonii; Aag-FG50; toxic fraction of Androctonus australis garzonii venom; AUC; area under the concentration versus time curve; AUMC; area unde

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2005 سفارش ترجمه