دانلود مقالات ISI درباره Tpmt + ترجمه فارسی

دستورالعمل موسسه انجمن گاستروآنترال آمریکا در مورد نظارت بر مواد مخدر در بیماری های روده ای التهابی

American Gastroenterological Association Institute Guideline on Therapeutic Drug Monitoring in Inflammatory Bowel Disease

Keywords: AGA; American Gastroenterological Association; CBC; complete blood count; CI; confidence interval; GRADE; Grading of Recommendations Assessment, Development and Evaluation; IBD; inflammatory bowel disease; RCT; randomized controlled trial; RR; relative ri

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2017 سفارش ترجمه

بیماری کرون: اپیدمیولوژی، تشخیص و مدیریت

Crohn Disease: Epidemiology, Diagnosis, and Management

Keywords: ADA; antidrug antibody; AGA; American Gastroenterological Association; Anti-TNF; anti-tumor necrosis factor; AZA; azathioprine; CD; Crohn disease; CTE; computed tomography enterography; EIM; extraintestinal manifestation; FDA; Food and Drug Administrati

دانلود رایگان متن کامل مقاله ISI 16 صفحه سال انتشار : 2017 سفارش ترجمه

استفاده از تیوپورین ها در طول مفهوم و بارداری با پیامدهای بارداری ناخواسته یا سلامت نوزادان در یک سال مطالعه در آینده نگر

Use of Thiopurines During Conception and Pregnancy Is Not Associated With Adverse Pregnancy Outcomes or Health of Infants at One Year in a Prospective Study

Keywords: Immunomodulators; Drug; Side Effect; Risk; Neonate; Infant; 6-MMP; 6-methylmercaptopurine; 6-TGN; 6-thioguanine nucleotides; aOR; adjusted odds ratio; AZA; azathioprine; BMI; body mass index; CD; Crohn's disease; CI; confidence interval; cOR; crude odds

دانلود رایگان متن کامل مقاله ISI 33 صفحه سال انتشار : 2017 سفارش ترجمه

سهم فارماکوژنتیک در مصرف داروها

The contribution of pharmacogenetics to pharmacovigilance

Keywords: Pharmacogenetics; Pharmacovigilance; Adverse drug reactions; UGT1A1; TPMT; DPYD; CYP2D6; VKORC1/CYP2C9; CYP2C19; HLA;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2016 سفارش ترجمه

دستورالعمل های بالینی برای مدیریت پزشکی بیماری کولیت اولسراتیو بدون بیماری: توافق تورنتو

Clinical Practice Guidelines for the Medical Management of Nonhospitalized Ulcerative Colitis: The Toronto Consensus

Keywords: Ulcerative Colitis; 5-Aminosalicylate; Corticosteroid; Thiopurine; Anti-Tumor Necrosis Factor; Vedolizumab; Probiotics; ADA; antidrug antibodies; CAG; Canadian Association of Gastroenterology; CI; confidence interval; FMT; fecal microbial transplant; GR

دانلود رایگان متن کامل مقاله ISI 27 صفحه سال انتشار : 2015 سفارش ترجمه

اثر فارماکوکینتیک آدالیموایاب بر متابولیسم تیوپورین در بیماران کرون

The pharmacokinetic effect of adalimumab on thiopurine metabolism in Crohn's disease patients

Keywords: AZA; azathioprine; CDAI; Crohn's disease activity index; 95% CI; 95% confidence interval; CRP; C-reactive protein; CD; Crohn's disease; HGPRT; hypoxanthine-guanine phosphoribosyl transferase; HPLC; high performance liquid chromatography; IBD; inflammatory

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2014 سفارش ترجمه

دستورالعمل های مراقبت از مدیریت آتروپیک؟ درماتیت

Guidelines of care for the management of atopic dermatitis

Keywords: atopic dermatitis; azathioprine; cyclosporin A; interferon gamma; methotrexate; mycophenolate mofetil; oral antihistamines; oral antimicrobials; oral steroids; photochemotherapy; phototherapy; systemic therapy; AAD; American Academy of Dermatology; AD; at

دانلود رایگان متن کامل مقاله ISI 23 صفحه سال انتشار : 2014 سفارش ترجمه

Significance of A-to-I RNA editing of transcripts modulating pharmacokinetics and pharmacodynamics

Keywords: ABC; ATP-binding cassette transporter; ADAR; adenosine deaminase acting on RNA; ADH; alcohol dehydrogenase; AhR; aryl hydrocarbon receptor; AKR; aldo-keto reductase; ALS; amyotrophic lateral sclerosis; AZIN1; antizyme inhibitor 1; AMPA; α-amino-3-hydroxy

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2018 سفارش ترجمه

Allele frequencies of thiopurine S-methyltransferase (TPMT) variants in the Nigerian population

Keywords: TPMT; Nigerians; Thiopurine; Genotype;

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2017 سفارش ترجمه

NUDT15 p.R139C variant is common and strongly associated with azathioprine-induced early leukopenia and severe alopecia in Korean patients with various neurological diseases

Keywords: Korea; Leukopenia; NUDT15; TPMT; Azathioprine;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2017 سفارش ترجمه

Pharmacogenomics: Precision Medicine and Drug Response

Keywords: CYP; cytochrome P450; EHR; electronic health record; eMERGE; Electronic Medical Records and Genomics; GWAS; genome-wide association study; NGS; next-generation sequencing; NIH; National Institutes of Health; ns; nonsynonymous; PGRN; Pharmacogenomics Resea

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2017 سفارش ترجمه

Pharmacogénétique des médicaments anticancéreux : état des connaissances et des pratiques - recommandations du Réseau national de pharmacogénétique (RNPGx)

Keywords: Pharmacogénétique; DPD; UGT1A1; TPMT; Anticancéreux; Oncologie;

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2017 سفارش ترجمه

Determination of thiopurine S-methyltransferase activity by hydrophilic interaction liquid chromatography hyphenated with mass spectrometry

Keywords: 6-MMP; 6-methylmercaptopurine; 6-MP; 6-mercaptopurine; 6-TG; 6-thioguanine; AZA; azathioprine; Cl-P; 6-chloropurine; DTT; dithiothreitol; IBD; inflammatory bowel diseases; RBC; red blood cells; SAM; S-adenosyl-l-methionine; TGN; thioguanine nucleotides; T

دانلود رایگان متن کامل مقاله ISI 31 صفحه سال انتشار : 2017 سفارش ترجمه

Development and validation of a reliable method for thiopurine methyltransferase (TPMT) enzyme activity in human whole blood by LC-MS/MS: An application for phenotypic and genotypic correlations

Keywords: LC-MS/MS; TPMT; 6-MP; 6-MMP; Whole blood;

دانلود رایگان متن کامل مقاله ISI 31 صفحه سال انتشار : 2017 سفارش ترجمه

Pharmacogenetics of anti-cancer drugs: State of the art and implementation - recommendations of the French National Network of Pharmacogenetics

Keywords: Pharmacogenetics; DPD; UGT1A1; TPMT; Cancer; Oncology;

دانلود رایگان متن کامل مقاله ISI 32 صفحه سال انتشار : 2017 سفارش ترجمه

TPMT and ITPA genetic variants in Lithuanian inflammatory bowel disease patients: Prevalence and azathioprine-related side effects

Keywords: Azathioprine; IBD; TPMT; ITPA; Polymorphism;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2016 سفارش ترجمه

Apport de la pharmacogénétique à la pharmacovigilance

Keywords: Pharmacogénétique; Pharmacovigilance; Effets indésirables médicamenteux; UGT1A1; TPMT; DPYD; CYP2D6; VKORC1/CYP2C9; CYP2C19; HLA;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2016 سفارش ترجمه

Liquid chromatography-mass spectrometry for measuring deoxythioguanosine in DNA from thiopurine-treated patients

Keywords: ALL; Acute childhood leukemia; 6-MP or MP; 6-mercaptopurine; AZA; azathioprine; IBD; inflammatory bowel disease; MeMP; methylmercaptopurine; MeMP-d3; Methymercaptopurine-D3; TIMP; thioinosine monophosphate; TIDP; thioinosine diphosphate; TITP; thioinosine

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2016 سفارش ترجمه

Structural and functional impact of missense mutations in TPMT: An integrated computational approach

Keywords: Bioinformatic analysis; TPMT; Missense mutations; Structure-function relationship

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2015 سفارش ترجمه

Identification of Patients With Variants in TPMT and Dose Reduction Reduces Hematologic Events During Thiopurine Treatment of Inflammatory Bowel Disease

Keywords: Leukocyte; Adverse Event; Pharmacogenetic; Side Effect; ADR; adverse drug reaction; CD; Crohn's disease; CRP; C-reactive protein; ESR; erythrocyte sedimentation rate; HBI; Harvey-Bradshaw Index; IBD; inflammatory bowel disease; RBC; red blood cell; TO

دانلود رایگان متن کامل مقاله ISI 18 صفحه سال انتشار : 2015 سفارش ترجمه

EASL Clinical Practice Guidelines: Autoimmune hepatitis

Keywords: ACG; American College of Gastroenterology; AGA; American Gastroenterological Association; ANCA; Antineutrophil cytoplasmic antibodies; APECED; Autoimmune polyendocrinopathy-cadidiasis ectodermal dystrophy; AS; acute severe autoimmune; CNI; Calcineurin inh

دانلود رایگان متن کامل مقاله ISI 34 صفحه سال انتشار : 2015 سفارش ترجمه

Development of a rapid clinical TPMT genotyping assay

Keywords: TPMT; Thiopurine S-methyltransferase; Allelic discrimination; TaqMan; Laboratory developed test

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2014 سفارش ترجمه

Research ArticlePrognostic value of muscle atrophy in cirrhosis using psoas muscle thickness on computed tomography

Keywords: CT; Computed tomography; BMI; body mass index; HCC; hepatocellular carcinoma; SD; standard deviation; ICC; intraclass correlation coefficient; CI; confidence interval; HR; hazard ratio; APMT; axial psoas muscle thickness; TPMT; transversal psoas muscle th

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2014 سفارش ترجمه

The Cost-Effectiveness of a Pharmacogenetic Test: A Trial-Based Evaluation of TPMT Genotyping for Azathioprine

Keywords: cost-effectiveness; pharmacogenetics; prospective; RCT; TPMT;

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2014 سفارش ترجمه

ITPA (inosine triphosphate pyrophosphatase): From surveillance of nucleotide pools to human disease and pharmacogenetics

Keywords: Nucleotide pool; ITPA gene polymorphism; Pharmacogenetics; Base analogs; Mercaptopurines; Protein stability; Dominant negative; ITPA; inosine triphosphate pyrophosphatase; ITP; inosine triphosphate; XTP; xanthosine triphosphate; HAM1; Saccharomyces cerevi

دانلود رایگان متن کامل مقاله ISI 16 صفحه سال انتشار : 2013 سفارش ترجمه

Thiopurine S-methytransferase Gene Polymorphism in Rheumatoid Arthritis

Keywords: Genotyping; Jordanians; Rheumatoid arthritis; TPMT; Thiopurine S-methyltransferase; Variant alleles

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2013 سفارش ترجمه

Oral azathioprine for recalcitrant pediatric atopic dermatitis: Clinical response and thiopurine monitoring

Keywords: atopic dermatitis; azathioprine; eczema; monitoring; pediatric; thiopurine metabolites; thiopurine methyltransferaseAD, atopic dermatitis; MMP, methylmercaptopurine; RBC, red blood cell; SCORAD, SCORing Atopic Dermatitis; TGN, thioguanine nucleotide; TPMT

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2013 سفارش ترجمه

Y a-t-il intérêt à doser les métabolites de l'azathioprine chez les malades ayant une maladie inflammatoire chronique de l'intestin?

Keywords: maladie inflammatoire chronique de l'intestin; azathioprine; 6-thioguaninenucléotide; 6-méthyl mercaptopurine; inflammatory bowel disease; azathioprine; 6-thioguanine nucleotide; 6- methyl mercaptopurine; 6-MP; 6-mercaptopurine; 6MMP; 6 méthylmercapt

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2013 سفارش ترجمه

My Treatment Approach to the Management of Ulcerative Colitis

Keywords: BMS; bowel movements; CBC; complete blood cell; CMV; cytomegalovirus; CRP; C-reactive protein; FCP; fecal calprotectin; GETAID; Groupe d'Etude Thérapeutique des Affections Inflammatories du Tube Digestif; IBD; irritable bowel disease; PIANO; Pregnancy in

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2013 سفارش ترجمه

S-allyl derivatives of 6-mercaptopurine are highly potent drugs against human B-CLL through synergism between 6-mercaptopurine and allicin

Keywords: 6-Mercaptopurine; Allicin; S-allyl thio-mercaptopurine; Pro-apoptotic; Induction of death in B-CLL cells; Human B-CLL in vivo model in mice; 6-MP; 6-mercaptopurine; 6-MPR; 6-mercaptopurine riboside; B-CLL; human B chronic lymphocytic leukemia; CLL; chroni

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2012 سفارش ترجمه

Hepatotoxicity associated with 6-methyl mercaptopurine formation during azathioprine and 6-mercaptopurine therapy does not occur on the short-term during 6-thioguanine therapy in IBD treatment

Keywords: 6-MMP; 6-methyl mercaptopurine; AZA; azathioprine; 6-MP; 6-mercaptopurine; 6-TG; 6-thioguanine; 6-TGN; 6-thioguanine nucleotides; TPMT; thiopurine S-methyl transferase; HBI; Harvey-Bradshaw Index; MTLWI; Modified Truelove and Witts Index; 6-Thioguanine;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2012 سفارش ترجمه

Thiopurine treatment in inflammatory bowel disease: Response predictors, safety, and withdrawal in follow-up

Keywords: Azathioprine; 6-mercaptopurine; TPMT; 6-TGN; 6-MMP; Safety;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2012 سفارش ترجمه

Evidence and consensus based GKJR guidelines for the treatment of juvenile idiopathic arthritis

Keywords: ACR; American College of Rheumatology; AE; adverse events; AGREE; appraisal of guidelines for research and evaluation; AWMF; Association of the Scientific Medical Associations; Bw; bodyweight; CAPS; cryopyrin-associated periodic syndromes; CD; cluster of

دانلود رایگان متن کامل مقاله ISI 18 صفحه سال انتشار : 2012 سفارش ترجمه

Limitations of extensive TPMT genotyping in the management of azathioprine-induced myelosuppression in IBD patients

Keywords: TPMT; IBD; Myelosuppression; Leucopenia; Azathioprine; TPMT mutations

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2011 سفارش ترجمه

Development and validation of a cost-effective in-house method, tetra-primer ARMS PCR assay, in genotyping of seven clinically important point mutations

Keywords: Tetra primer ARMS PCR; SNP; FVL; MTHFR; TPMT; AAT

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2011 سفارش ترجمه

MTHFR and TYMS genotypes influence TPMT activity and its differential modulation in males and females

Keywords: TPMT; MTHFR; TYMS; Pharmacogenetics; 6-mercaptopurine

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2010 سفارش ترجمه

Research ArticleCharacterisation and utility of thiopurine methyltransferase and thiopurine metabolite measurements in autoimmune hepatitis

Keywords: Autoimmune hepatitis; Thiopurines; Thiopurine methyltransferase; Thiopurine metabolites; Drug monitoring; AZA; azathioprine; AiH; autoimmune hepatitis; TP; thiopurine; TPMT; thiopurine methyltransferase; TGN; thioguanine nucleotide; meTIMP; methylthioinos

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2010 سفارش ترجمه

A prospective evaluation of the impact of allopurinol in pediatric and adult IBD patients with preferential metabolism of 6-mercaptopurine to 6-methylmercaptopurine

Keywords: IBD; Thiopurine; 6-MP; 6-TG; 6-MMP; Allopurinol; TPMT;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2010 سفارش ترجمه

The Genetic Profile and Monitoring of Acute Lymphoblastic Leukemia in Children and Adolescents

Keywords: Acute lymphoblastic leukemia; Molecular monitoring; TPMT

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2009 سفارش ترجمه

Duplex pyrosequencing of the TPMT⁎3C and TPMT⁎6 alleles in Korean and Vietnamese populations

Keywords: Duplex pyrosequencing assay; TPMT; Polymorphism; Vietnamese

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2008 سفارش ترجمه

Sweet Syndrome as a Manifestation of Azathioprine Hypersensitivity

Keywords: IBD; inflammatory bowel disease; SS; Sweet syndrome; TPMT; thiopurine methyltransferase;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2008 سفارش ترجمه

Absence of nodular regenerative hyperplasia after low-dose 6-thioguanine maintenance therapy in inflammatory bowel disease patients

Keywords: Hepatotoxicity; Inflammatory bowel disease; Nodular regenerative hyperplasia; 6-Thioguanine; 6-Thioguaninenucleotides; TPMT

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2008 سفارش ترجمه

Thiopurine Dose in Intermediate and Normal Metabolizers of Thiopurine Methyltransferase May Differ Three-Fold

Keywords: CI; confidence interval; CRP; C-reactive protein; ESR; erythrocyte sedimentation rate; IBD; inflammatory bowel disease; IQ; interquartile; 6-MMPN; 6-methylmercaptopurine nucleotides; 6-MP; 6-mercaptopurine; RBC; red blood cell; 6-TGN; 6-thioguanine nucleo

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2008 سفارش ترجمه

A novel gene delivery system for stable transfection of thiopurine-S-methyltransferase gene in versatile cell types

Keywords: Artificial viral particle; TPMT; Non-viral vector; Transfection; Gene delivery; Plasmid DNA; Nanoparticles; Thiopurine-S-methyltransferase

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2008 سفارش ترجمه

Management of Steroid-Dependent Ulcerative Colitis: Immunomodulatory Agents, Biologics, or Surgery?

Keywords: ACT; Active Ulcerative Colitis Trial; AZA; azathioprine; FDA; Food and Drug Administration; IPAA; ileal pouch-anal anastomosis; 6MP; 6-mercaptopurine; QOL; quality of life; TPMT; thiopurine methyltransferase; UC; ulcerative colitis;

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2007 سفارش ترجمه

Primer on the human genome

Keywords: CGH; comparative genomic hybridization; 2D; two-dimensional; DCM; disease-causing mutation; HapMap; International Haplotype Map [project]; mRNA; messenger RNA; PCLBCL; primary cutaneous large B-cell lymphoma; SNP; single nucleotide polymorphism; TNF; tumo

دانلود رایگان متن کامل مقاله ISI 17 صفحه سال انتشار : 2007 سفارش ترجمه

Incidence of Neoplasms in Patients Who Develop Sustained Leukopenia During or After Treatment With 6-Mercaptopurine for Inflammatory Bowel Disease

Keywords: AZA; azathioprine; IBD; inflammatory bowel disease; 6-MP; 6-mercaptopurine; 6-TG; 6-thioguanine; TPMT; thiopurine methyl transferase;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2006 سفارش ترجمه

Inosine Triphosphate Pyrophosphatase and Thiopurine S-Methyltransferase Genotypes Relationship to Azathioprine-Induced Myelosuppression

Keywords: AZA; azathioprine; CI; confidence interval; IBD; inflammatory bowel disease; ITPA; gene encoding inosine triphosphate pyrophosphatase; ITPase; inosine triphosphate pyrophosphatase; OR; odds ratio; TPMT; thiopurine S-methyltransferase; PCR; polymerase chai

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2006 سفارش ترجمه

Genetics of Rheumatoid Arthritis

Keywords: AICAR-T; aminoimidazole carboxamide ribonucleotide transformylase; CRH; corticotropin-releasing hormone; DMARD; disease-modifying antirheumatic drug; IL; interleukin; MHC; major histocompatibility complex; MTHFR; methylenetetrahydrofolate reductase; RA; r

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2006 سفارش ترجمه

Pharmacogenomics in Inflammatory Bowel Disease

Keywords: AZA; azathioprine; IBD; inflammatory bowel disease; ITPA; inosine triphosphate pyrophosphatase; 6-MP; 6-mercaptopurine; NAT; arylamine N-acetyltransferases; SNP; single nucleotide polymorphism; 6-TGN; 6-thioguanine nucleotides; TPMT; thiopurine methyltran

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2006 سفارش ترجمه