Keywords: AP-1; activator protein 1; DAMP; damage associated molecular patterns; IRAK1; interleukin-1 receptor associated kinase-1; LBP; LPS binding protein; LPS; lipopolysaccharide; MAPK; mitogen-activated protein kinase; MD2; myeloid differentiation factor 2; MHC
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Keywords: AKP; alkaline phosphatase; ALA; α-linolenic acid; ALT; alanine aminotransferase; AST; aspartate aminotransferase; BW; body weight; COX2; cyclooxygenase 2; DAMP; damage-associated molecular pattern; ERK1/2; extracellular signal-regulated kinase 1/2; GGT;
Keywords: Propolis; Apis mellifera bee; Anti-Inflammatory; Neutrophils; Leukocyte; AP-1; activator protein-1; CXCL1/KC; chemokine ligand 1/KC, keratinocyte chemoattractant; CXCL2/MIP-2; chemokine ligand 2/MIP-2, macrophage inflammatory protein 2; CXCR2; chemokine r
Keywords: Dry eye disease; Genetic epidemiology; Biomarkers; Transcriptomics; Aire; autoimmune regulatory gene; BLIMP-1; B lymphocyte-induced maturation protein-1; BMP; bone morphogenic protein; CCR5; chemokine receptor type 5; DED; dry eye disease; DHT; dihydrotes
Keywords: AAA; ATPases associated with diverse cellular activities; 17-AAG; 17-N-allylamino-17-demethoxygeldanamycin; ABC; ATP-binding cassette; ABCE1; ATP binding cassette subfamily E member 1; AD; Alzheimer's disease; AIF; apoptosis inducing factor; Akt; Alpha se
Keywords: TNF-α; muscle wasting; TWEAK; TRAF6
Keywords: AD; Alzheimer's disease; TLRs; toll-like receptors; AβPP; amyloid-β protein precursor; NSAIDs; non-steroidal anti-inflammatory drugs; CNS; central nervous system; TNF-α; tumor necrosis factor-α; IL-1β; interleukin 1-β; IL-6; interleukin-6; NO; nit
Keywords: MNCs; multinucleated cells; TRAP; tartrate-resistant acid phosphatase; RANKL; receptor activator of nuclear factor-κB ligand; M-CSF; macrophage colony stimulating factor; OPG; osteoprotegerin; c-fms; colony-stimulating factor-1 receptor; ERK; extracellul
Keywords: AP1; Activator protein 1; cAMP; Cyclic adenosine monophoshate; CXCR; Cytokine receptors; CRTH2; Chemoattractant receptor-homologous molecule expressed on Th2 cells; DAMPs; Damage-associated molecular pattern; EtBr; Ethidium Bromide; IgE; Immunoglobulin E;
Keywords: RA; rheumatoid arthritis; DCs; dendritic cells; TolDCs; tolerogenic dendritic cells; NSAIDs; non-steroidal anti-inflammatory drugs; GC; glucocorticoids; DMARDs; disease-modifying anti-rheumatic drugs; TLRs; toll-like receptors; CLRs; cell surface C-type l
Keywords: DAMP; danger-associated molecular pattern; GWAS; genome-wide association studies; IL; interleukin; iNOS; inducible nitric oxide synthase; iTreg; inflammatory suppressing inducible regulatory T cells; LPS; lipopolysaccharide; MHC; major histocompatibility;
Keywords: LPS; lipopolysaccharide; TLR4; toll-like receptor-4; RANKL; receptor activator of nuclear factor κB ligand; RANK; receptor activator of nuclear factor κB; FBGC; foreign body giant cell; MEMκ; minimum essential medium alpha medium; PBS; phosphate-buffer
Keywords: CD14; cluster of differentiation 14; dsRNA; double stranded ribonucleic acid; IFN; interferon; IL; interleukin; IRAK; interleukin-1 receptor-associated kinase; IRF3; interferon regulatory factor 3; LBP; lipopolysaccharide-binding protein; LPS; lipopolysac
Keywords: 3â²UTR; 3â² untranslated region; Ago2; Argonaute 2; CCN5; cysteine-rich 61/connective tissue growth factor/nephroblastoma overexpressed 5; ChIP; chromatin immunoprecipitation; CUL2; cullin2; DGCR8; Di George syndrome critical region 8; DMNT; DNA methylt
Keywords: Otitis media; miR-146a; miR-146b; IRAK1; TRAF6; Toll-like receptor
Keywords: Genetics; IRAK4; MyD88; T2DM; TRAF6
Two novel serine proteases from Scylla paramamosain involved in the synthesis of anti-lipopolysaccharide factors and activation of prophenoloxidase system
Keywords: Scylla paramamosain; Serine protease; TRAF6; ALFs; Prophenoloxidase;
Role of Malt1 protease activity in pathogenesis of inflammatory disorders mediated by FcγR signaling
Keywords: BAC; bacteria artificial chromosome; BMDC; bone marrow-derived dendritic cell; CYLD; cylindromatosis; FBS; fetal bovine serum; FITC; fluorescein isothiocyanate; FcγR; Fcγ receptor; FcR; Fc receptor; GM-CSF; Granulocyte macrophage colony-stimulating fact
MicroRNA-146a promotes red spotted grouper nervous necrosis virus (RGNNV) replication by targeting TRAF6 in orange spotted grouper, Epinephelus coioides
Keywords: miR-146a; RGNNV; Grouper; TRAF6; Viral infection;
Autoimmune sialadenitis is associated with the upregulation of chemokine/chemokine receptor pairs in T cell-specific TRAF6-deficient mice
Keywords: Chemokine/chemokine receptor pairs; Salivary glands; Sialadenitis; TRAF6; TRAF6-deficient mice;
Calycosin inhibits nasopharyngeal carcinoma cells by influencing EWSAT1 expression to regulate the TRAF6-related pathways
Keywords: Calycosin; Nasopharyngeal carcinoma; EWSAT1; TRAF6;
TRAF6 mediates high glucose-induced endothelial dysfunction
Keywords: TRAF6; High glucose; Endothelial dysfunction; Diabetes;
Trichloroethylene perturbs HNF4a expression and activity in the developing chick heart
Keywords: TCE; Benfluorex; Heart defects; CYP2C45; CYP2H1; TRAF6; NFKBIE; Nonmonotonic dose response;
Hyaluronan in experimental injured/inflamed cartilage: In vivo studies
Keywords: ACAN; aggrecan; ADAMTS-5; A disintegrin and metalloproteinase with thrombospondin motifs 5; A2AR; adenosine type 2 receptor; Bax; BCL2 associated X protein; Bcl-2; B-cell lymphoma 2; CD44; cluster determinant 44; Col2A; collagen type II alpha; Col1a1; col
Butyrate ameliorated-NLRC3 protects the intestinal barrier in a GPR43-dependent manner
Keywords: T2DM; type 2 diabetes; PRRs; pattern recognition receptors; TLRs; toll-like receptors; NOD; nucleotide-binding oligomerization domain; NLRs; nucleotide-binding oligomerization domain (NOD)-like receptors; MAMPs; microbe-associated molecular patterns; NLRP
Tea polysaccharide inhibits RANKL-induced osteoclastogenesis in RAW264.7 cells and ameliorates ovariectomy-induced osteoporosis in rats
Keywords: BMD; bone mineral density; RANKL; receptor activator nuclear factor-kappa B ligand; M-CSF; macrophage colony-stimulating factor; TPS; tea polysaccharide; OVX; ovariectomized; IL-1β; interleukin-1β; IL-6; interleukin-6; ELISA; enzyme-linked immunosorbent
Differential gene modulation of pattern-recognition receptor TLR and RIG-I-like and downstream mediators on intestinal mucosa of pigs infected with PEDV non S-INDEL and PEDV S-INDEL strains
Keywords: Porcine epidemic diarrhea virus; Toll-like receptor; RIG-I-like receptors; MyD88; TRAF6; IRF7; NF-κB; Pro-inflamatory cytokines; Type 1 interferon; Canonical pathway;
Ubiquitination and SUMOylation in the chronic inflammatory tumor microenvironment
Keywords: Inflammation-associated cancer; Ubiquitin-proteasome system (UPS); Small ubiquitin-like modifier (SUMO); Tumor microenvironment; Cytokine profile; Transcription factors; 15d-PGJ2; 15-Deoxy-Delta-12,14-prostaglandin J2; AR; androgen receptor; Ala; alanine;
TRIM38 regulates NF-κB activation through TAB2 degradation in osteoclast and osteoblast differentiation
Keywords: TRIM38; tripartite motif 38; BMM; bone marrow-derived macrophage-like cell; NFATc1; nuclear factor of activated T-cells c1; TRAP; tartrate-resistant acid phosphatase; RANKL; receptor activator of nuclear factor kappa B ligand; M-CSF; macrophage colony sti
Defective protein repair under methionine sulfoxide A deletion drives autophagy and ARE-dependent gene transcription
Keywords: ARE; antioxidant response element; CaMKII; Ca2+/calmodulin-dependent kinase II; GCLC; glutamate-cysteine ligase; GR; glutathione reductase; GSH; reduced glutathione; GSSG; oxidized glutathione; IκK; inhibitor of nuclear factor kappa-B kinase; Keap-1; Kel
Biological characterization, expression, and functional analysis of tumor necrosis factor receptor-associated factor 6 in Nile tilapia (Oreochromis niloticus)
Keywords: Oreochromis niloticus; TRAF6; Infection; mRNA expression;
Rig-I is involved in inflammation through the IPS-1/TRAF6 pathway in astrocytes under chemical hypoxia
Keywords: RIG-I; retinoic acid-inducible gene I; IPS-1; interferon-β promoter stimulator-1; TRAF; TNF receptor-associated factor; PRRs; pattern recognition receptors; TLRs; toll-like receptors; NLRs; NOD-like receptors; RLRs; RIG-like receptors; MDA5; melanoma dif
Activation of the STING-IRF3 pathway promotes hepatocyte inflammation, apoptosis and induces metabolic disorders in nonalcoholic fatty liver disease
Keywords: ALT; Alanine aminotransferase; AST; Aspartate aminotransferase; AUC; Area under the curve; BW; body weight; DMEM; Dulbecco's modified Eagle's medium; ER; endoplasmic-reticulum; FBS; fetal bovine serum; FFA; free fatty acid; GCK; glucokinase; p-GSK3β; pho
BCL3 regulates RANKL-induced osteoclastogenesis by interacting with TRAF6 in bone marrow-derived macrophages
Keywords: TRAF6; tumor necrosis factor receptor-associated factor 6; BCL3; B-cell chronic lymphatic leukemia protein 3; TAK1; transforming growth factor β-activated kinase 1; RANKL; Receptor activator of nuclear factor-κB ligand; NFATC1; nuclear factor of activat
miR-146a regulates inflammatory cytokine production in Porphyromonas gingivalis lipopolysaccharide-stimulated B cells by targeting IRAK1 but not TRAF6
Keywords: miRs; microRNAs; P. gingivalis; Porphyromonas gingivalis; LPS; lipopolysaccharide; PBS; phosphate buffer saline; IL; interleukin; IRAK1; IL-1 receptor associated kinase-1; TRAF6; TNF receptor associated factor 6; UTR; untranslated region; A. actinomycetem
Smoothened stabilizes and protects TRAF6 from degradation: A novel non-canonical role of smoothened with implications in lymphoma biology
Keywords: SMO; TRAF6; Diffuse large B cell lymphoma; Hedgehog signaling pathway;
Ontogenetic and expression of different genes involved in the Toll pathway of black tiger shrimp (Penaeus monodon) following immersion challenge with Vibrio harveyi and white spot syndrome virus (WSSV)
Keywords: Penaeus monodon; Toll-pathway; Ontogeny; Immersion challenge; Vibrio harveyi; white spot syndrome virus (WSSV); ANOVA; Analysis of variance; CFU; Colony forming units; dpi; Days post infection; EFα; Elongation factor α; hpi; Hour post-infection; MyD88;
Efferocytosis in atherosclerotic lesions: Malfunctioning regulatory pathways and control mechanisms
Keywords: ABC; ATP-binding cassette; ABCA1; ATP-binding membrane cassette transporter A1; ABCG1; ATP binding cassette transporter G1; ABCA7; ATP-binding cassette transporters A7; Abs; Antibodies; ACs; Apoptotic cells; AICAR; 5-aminoimidazole-4-carboxamide-1-β-d-ri
Anti-osteoclastic effect of caffeic acid phenethyl ester in murine macrophages depends upon the suppression of superoxide anion production through the prevention of an active-Nox1 complex formation
Keywords: CAPE; caffeic acid phenethyl ester; RANKL; receptor activator of nuclear factor-κB ligand; TRAP; tartrate-resistant acid phosphatase; ROS; reactive oxygen species; Nox1; NADPH (nicotinamide adenine dinucleotide phosphate) oxidase 1; NF-κB; nuclear facto
Identification and analyses of natural compounds as potential inhibitors of TRAF6-Basigin interactions in melanoma using structure-based virtual screening and molecular dynamics simulations
Keywords: Melanoma metastasis; ZINC database; Virtual screening; Molecular docking; Molecular dynamics simulations; Lead optimization; TRAF6; Basigin;
MicroRNA-mediated immune regulation in rheumatic diseases
Keywords: Rheumatism; Small non-coding RNAs; Autoimmunity; Lupus; Rheumatoid arthritis; miR- /miRNA; microRNA; AGO; argonaute; RISC; RNA-induced silencing complex; PBMCs; peripheral blood mononuclear cells; SLE; systemic lupus erythematosus; RA; rheumatoid arthriti
A 5-hydroxyoxindole derivative attenuates LPS-induced inflammatory responses by activating the p38-Nrf2 signaling axis
Keywords: ASK1; apoptosis signal regulating kinase 1; Cul3; cullin 3; DEF; dimethylfumarate; DEM; diethylmaleate; 15d-PGJ2; 15-deoxy-Î12,14-prostaglandin J2; FBS; fetal bovine serum; 5-HI; 5-hydroxyoxindole derivative; HO-1; heme oxygenase-1; iNOS; inducible NO sy
Up-regulation of circulating miRNA146a correlates with viral load via IRAK1 and TRAF6 in hepatitis C virus-infected patients
Keywords: HCV; IRAK1; miRNA146a; TRAF6; Viral load;
Deubiquitinase USP12 promotes LPS induced macrophage responses through inhibition of IκBα
Keywords: USP12; LPS; Macrophages; Inflammation; CYLD; Cylindromatosis; DUBA; deubiquitinating enzyme A; iNOS; inducible nitric oxide synthase; PTMs; Post translational modifications; TRAF3; TNF receptor associated factor 3; TRAF6; TNF receptor associated factor 6;
Differential regulation of IL-23 production in M1 macrophages by TIR8/SIGIRR through TLR4- or TLR7/8-mediated signaling
Keywords: Granulocyte-macrophage colony-stimulating factor; IL-12p40; IL-23; Interferon regulatory factor 5; Single immunoglobulin interleukin-1 receptor-related molecule; ELISA; enzyme-linked immunosorbent assay; GMâCSF; granulocytemacrophage colony-stimulatin
Escherichia coli maltose-binding protein (MBP) activates mouse Th1 through TLR2-mediated MyD88-dependent pathway and TLR4-mediated TRIF-dependent pathway
Keywords: MBP; MyD88; TRIF; TRAF3; TRAF6;
Tumor necrosis factor receptor-associated factor (TRAF) 6 inhibition mitigates the pro-inflammatory roles and proliferation of rheumatoid arthritis fibroblast-like synoviocytes
Keywords: TRAF6; tumor necrosis factor receptor-associated factor 6; FLS; fibroblast-like synoviocyte; RA; rheumatoid arthritis; OA; osteoarthritis; MMP; matrix metalloproteinase; IF; immunofluorescence; TNF-α; tumor necrosis factor α; ELISA; enzyme-linked immuno
Full length articleTumor necrosis factor receptor-associated factor 6 (TRAF6) participates in peroxinectin gene expression in Fenneropenaeus penicillatus
Keywords: Fenneropenaeus penicillatus; TRAF6; Peroxinectin; WSSV; Vibrio alginolyticus; Gene expression;
Innate immunity related pathogen recognition receptors and chronic hepatitis B infection
Keywords: acLDL; acylated LDL; AIM2; absent in melanoma 2; AP-1; activator protein 1; BDCA-2; blood DC antigen; BEC; biliary epithelial cells; CARD; caspase recruitment and activation domains; cDC; common dendritic cells; CL-L1; collectin liver 1; CL-K1; collectin
Regulatory effects of miR-146a/b on the function of endothelial progenitor cells in acute ischemic stroke in mice
Keywords: MicroRNA-146a/b; Acute ischemic stroke; Endothelial progenitor cells; TRAF6; IRAK1;