Targeting species specific amino acid residues: Design, synthesis and biological evaluation of 6-substituted pyrrolo[2,3-d]pyrimidines as dihydrofolate reductase inhibitors and potential anti-opportunistic infection agents
Keywords: تریمترکسات; Pj; Pneumocystis jirovecii; PCP; Pneumocystis pneumonia; ART; antiretroviral therapy; TMP; trimethoprim; SMX; sulfamethoxazole; DHFR; dihydrofolate reductase; DHPS; dihydropteroate synthase; PTX; piritrexim; TMQ; trimetrexate; PC; Pneumocystis carinii; DH