Keywords: TS، تیمیدیلات سنتاز; 5-FU, 5-fluorouracil; CRC, colorectal cancer; TS, thymidylate synthase; TSER, thymidylate synthase enhancer region; MTHFR, methylenetetrahydrofolate reductase; RFC1, reduced folate carrier 1; OS, overall survival; RFS, relapse-free survival; HR, hazard ra
مقالات ISI TS، تیمیدیلات سنتاز (ترجمه نشده)
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Crystal structure of phosphoramide-phosphorylated thymidylate synthase reveals pSer127, reflecting probably pHis to pSer phosphotransfer
Keywords: TS، تیمیدیلات سنتاز; TS, thymidylate synthase; KPA, potassium phosphoramidate; MOAC, metal oxide/hydroxide affinity chromatography; CeTS, recombinant C. elegans TS; MOAC-separated, from its phosphorylated fraction; CepTS, CeTS phosphorylated by KPA and phosphoprotein-enriched
Biodistribution and radiation dosimetry of [18F]-5-fluorouracil
Keywords: TS، تیمیدیلات سنتاز; PET, positron emission tomography; TS, thymidylate synthase; F-RNA, F-ribonucleic acid; [18F]-5-FU, 5-fluorouracil labeled with 18F; DPD, dihydropyrimidine dehydrogenase; FBAL, alpha-fluoro-beta-alanine; OLINDA, Organ Level Internal Dose Assessment Code;
Expression and regulation of RAD51 mediate cellular responses to chemotherapeutics
Keywords: TS، تیمیدیلات سنتاز; HR, homologous recombination; DSBs, DNA double strand breaks; TS, thymidylate synthase; RTX, raltitrexed (Tomudex™); 5-FU, 5-fluorouracil; FdUrd, fluorodeoxyuridine; UCN-01, 7-Hydroxy-staurosporine; GFP, green fluorescent proteinThymidylate synthase; Homo
ATR–Chk1 signaling pathway and homologous recombinational repair protect cells from 5-fluorouracil cytotoxicity
Keywords: TS، تیمیدیلات سنتاز; 5-FU, 5-fluorouracil; FUTP, fluorouridine triphosphate; FdUTP, fluorodeoxyuridine triphosphate; FdUMP, fluorodeoxyuridine monophosphate; TS, thymidylate synthase; BER, base excision repair; MMR, mismatch repair; DSB, double-strand break; HRR, homologous r
In silico and in vitro validation of serine hydroxymethyltransferase as a chemotherapeutic target of the antifolate drug pemetrexed
Keywords: TS، تیمیدیلات سنتاز; Pemetrexed; SHMT; Antifolate; Pleural mesotheliomaSHMT, serine hydroxymethyltransferase; THF, tetrahydrofolate; H4PteGlu, tetrahydropteroylglutamate; TS, thymidylate synthase; DHFR, dihydrofolate reductase; dTMP, 2′-deoxythymidine monophosphate
An epigenetic mechanism for capecitabine resistance in mesothelioma
Keywords: TS، تیمیدیلات سنتاز; TS, thymidylate synthase; TP, thymidine phosphorylase; DPD, dihydropyrimidine dehydrogenase; DNMT, DNA methyltransferase; DFUR, 5′-deoxy-5-fluorouridine; ECGF-1, extracellular growth factor-1; 5-aza-CdR, 5-aza-2′-deoxycytidineThymidine phosphorylase; Cape
Influence of thymidylate synthase gene polymorphisms on total plasma homocysteine concentrations
Keywords: TS، تیمیدیلات سنتاز; tHcy, total plasma homocysteine; 5-methyl-THF, 5-methyltetrahydrofolate; MS, methionine synthase; SAM, S-adenosylmethionine; SAH, S-adenosylhomocysteine; TS, thymidylate synthase; UTR, untranslated region; TSER, thymidylate synthase enhancer region; G/C S
Phosphorylation of thymidylate synthase from various sources by human protein kinase CK2 and its catalytic subunits
Keywords: TS، تیمیدیلات سنتاز; TS, thymidylate synthase; meTHF, N5,10-methylenetetrahydrofolateThymidylate synthase; Phosphorylation; Protein kinase CK2; Catalytic subunits; Regulatory subunit
2,4-Diamino-5-methyl-6-substituted arylthio-furo[2,3-d]pyrimidines as novel classical and nonclassical antifolates as potential dual thymidylate synthase and dihydrofolate reductase inhibitors
Keywords: TS، تیمیدیلات سنتاز; TS, thymidylate synthase; dTMP, 2′-deoxythymidine-5′-monophosphate; dUMP, 2′-deoxyuridine-5′-monophosphate; DHFR, dihydrofolate reductase; dTDP, 2′-deoxythymidine-5′-diphosphate; dTTP, 2′-deoxythymidine-5′-triphosphate; MTX, methotrexate; GARFT, glycinami
Kinetic properties and specificity of trimeric Plasmodium falciparum and human dUTPases
Keywords: TS، تیمیدیلات سنتاز; Kinetic; Calorimetry; dUTPase; Plasmodium falciparum; Inhibition; Specificity; BindingdUTPase, dUTP pyrophosphatase (EC 3.6.1.23); ITC, isothermal titration calorimetry; TS, thymidylate synthase; FdUTP, 5-fluoro-2′-deoxyuridine 5′-triphosphate; IdUTP, 5-i
Mechanism of influence of phosphorylation on serine 124 on a decrease of catalytic activity of human thymidylate synthase
Keywords: TS، تیمیدیلات سنتاز; meTHF, N5,10-methylenetetrahydrofolate; TS, thymidylate synthase; hTS, human thymidylate synthase; RMSF, root-mean-square fluctuation; (phos)hTS, phosphorylated hTS; THF, tetrahydrofolate; ED, essential dynamics; MD, molecular dynamics; PDB, protein data
Mechanism of DNA Methylation: The Double Role of DNA as a Substrate and as a Cofactor
Keywords: TS، تیمیدیلات سنتاز; DMT, DNA methyltransferase; AdoMet, S-adenosyl-l-methionine; TS, thymidylate synthase; M.HhaI, HhaI methyltransferase; dUMP, 2′-deoxyuridine 5′-monophosphateDNA cytosine methyltransferase; methylation reaction mechanism; DNA as cofactor; DNA phosphate gro
Significant association between methylenetetrahydrofolate reductase 677T allele and hyperuricemia among adult Japanese subjects
Keywords: TS، تیمیدیلات سنتاز; BMI, body mass index; CI, confidence interval; MTHFR, methylenetetrahydrofolate reductase; OR, odds ratio; PCR, polymerase chain reaction; SUA, serum uric acid; TRP, tandem repeat polymorphism; TS, thymidylate synthase; UA, uric acidGenetic polymorphism;
Gene expression profiling of leukemia T-cells resistant to methotrexate and 7-hydroxymethotrexate reveals alterations that preserve intracellular levels of folate and nucleotide biosynthesis
Keywords: TS، تیمیدیلات سنتاز; MTX, methotrexate; 7-OHMTX, 7-hydroxymethotrexate; IC50, the drug concentration inhibiting cell growth by 50%; DHFR, dihydrofolate reductase; TS, thymidylate synthase; RFC, reduced folate carrier; FPGS, folylpolyglutamate synthetase; FPGH, folylpolyglutam
Cloning and characterization of Plasmodium vivax serine hydroxymethyltransferase
Keywords: TS، تیمیدیلات سنتاز; Pf, Plasmodium falciparum; Pv, P. vivax; DHFR, dihydrofolate reductase; TS, thymidylate synthase; SHMT, serine hydroxymethyltransferase; PLP, pyridoxal phosphate; c, cytosol; mt, mitochondria; bp, base pairPlasmodium vivax; Serine hydroxymethyltransferase
Uracil incorporation into genomic DNA does not predict toxicity caused by chemotherapeutic inhibition of thymidylate synthase
Keywords: TS، تیمیدیلات سنتاز; TS, thymidylate synthase; BER, base excision repair; 5-FU, 5-fluorouracil; FdUrd, 5-fluoro-2′-deoxyuridine; RTX, raltitrexed (Tomudex); UDG, uracil DNA glycosylase; UNG, uracil DNA glycosylase from the UNG locus; UNG2, nuclear isoform of uracil DNA glycos
DNA damage and homologous recombination signaling induced by thymidylate deprivation
Keywords: TS، تیمیدیلات سنتاز; HR, homologous recombination; DSBs, DNA double strand breaks; TS, thymidylate synthase; RTX, raltitrexed (Tomudex™); BER, base excision repair; RPA, replication protein A; RPA2, 32-kDa subunit of replication protein A; γ-H2AX, phsophorylated histone prote
Uracil in DNA: Consequences for carcinogenesis and chemotherapy
Keywords: TS، تیمیدیلات سنتاز; TS, thymidylate synthase; TMP, thymidylate; TTP, thymidine triphosphate; dUMP, deoxyuridylate; dUTP, deoxyuridine triphosphate; CH2H4PteGlu, N5,N10-methylenetetrahydrofolate; 5-FU, 5-fluorouracil; FdUrd, 5-fluoro-2′-deoxyuridine; RTX, raltitrexed (Tomudex
Role of an invariant lysine residue in folate binding on Escherichia coli thymidylate synthase: Calorimetric and crystallographic analysis of the K48Q mutant
Keywords: TS، تیمیدیلات سنتاز; TS, thymidylate synthase; CH2THF, 5,10-methylene-5,6,7,8-tetrahydrofolate; dUMP, 2′-deoxyuridine-5′-monophosphate; dTMP, 2′-deoxythymidine-5′-monophosphate; FdUMP, 5-fluoro-dUMP; PDDF, 10-propargyl-5,8-dideazafolate; DTT, dithiotreithol; PABA, para-aminob
Targeting the α-folate receptor with cyclopenta[g]quinazoline-based inhibitors of thymidylate synthase
Keywords: TS، تیمیدیلات سنتاز; TS, thymidylate synthase; α-FR, α-folate receptor; FBP, folate binding protein; RFC, reduced folate carrier; DEPC, diethyl phosphorocyanidate; DIEA, diisopropylethylamine; TFA, trifluoroacetic acid; Glu, glutamic acid; Pg, propargyl