Keywords: TSA، Trichostatin A; Aryl hydrocarbon receptor; Curcumin; CYP1A1; Epigenetic; FICZAHR, aryl hydrocarbon receptor; CUR, curcumin; CYP1A1, cytochrome P4501A1; FICZ, 6-formylindolo[3,2-b]carbazole; HAT, histone acetyltransferase; HDAC, histone deacetylase; TSA, trichostatin A; 5
مقالات ISI TSA، Trichostatin A (ترجمه نشده)
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Lysine acetylation stabilizes SP2 protein in the silkworm Bombyx mori
Keywords: TSA، Trichostatin A; TSA, Trichostatin A; MTT, 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2-H-tetrazolium bromide; PTM, post-translational modification; p300, histone acetyltransferases p300; CREB, cAMP-response element binding protein; CBP, CREB binding protein; PCAF, p300/CB
Epigenetic drift towards histone modifications regulates CAV1 gene expression in colon cancer
Keywords: TSA، Trichostatin A; AZA, 5-Aza-2′-deoxycytidine; CAV1, Caveolin-1; DNMT1, DNA methyltransferase 1; SAM, S-adenosyl-l-methionin; TSA, trichostatin A; SFN, sulforaphen; H3K4me3, histone 3 lysine 4 trimethylation; H3K9me3, histone 3 lysine 9 trimethylation; H3K9AcS10p, histone
A SUMO-acetyl switch in PXR biology
Keywords: TSA، Trichostatin A; PXR, pregnane X receptor; TSA, trichostatin A; HDAC3, histone de-acetylase 3; SMRT, silencing mediator of retinoic acid and thyroid hormone receptor; PTM, post-translational modification; LC–MS/MS, liquid chromatography–tandem mass spectrometry; PIAS1, pr
Investigating the effects of in utero benzene exposure on epigenetic modifications in maternal and fetal CD-1 mice
Keywords: TSA، Trichostatin A; γH2AX, phosphorylated histone H2A variant X; TSA, trichostatin A; Parp-1, poly[ADP-ribose] synthase 1; HAT, histone acetyltransferase; Pten, phosphatase and tensin homolog; MAGE1, melanoma antigen 1; HDAC, histone deacetylase; DNMT, DNA methyl transferase
Distinct promoters, subjected to epigenetic regulation, drive the expression of two clusterin mRNAs in prostate cancer cells
Keywords: TSA، Trichostatin A; CLU, clusterin; TCF-1, T-cell factor-1; AP1, activating protein-1; AP2, activating protein-2; SP1, specificity protein 1; HSE, heat-shock response elements; CEBP, CCAAT-enhancer-binding protein; TSA, trichostatin A; NFI, nuclear factor I; YY1, Yin Yang 1;
Ectopic expression of Msx2 in mammalian myotubes recapitulates aspects of amphibian muscle dedifferentiation
Keywords: TSA، Trichostatin A; msx2, msh (muscle segment homeodomain) homeobox homolog 2; msx1, msh homeobox homolog 1; MHC, myosin heavy chain; Mrf4, muscle regulatory factor 4; Ptgs2, prostaglandin-endoperoxide synthase 2; Ptger4, prostaglandin E receptor 4; TSA, trichostatin A; BMP4
Transcriptional machinery of TNF-α-inducible YTH domain containing 2 (YTHDC2) gene
Keywords: TSA، Trichostatin A; CAHL, cyclosporin A (CsA) associated helicase-like protein; YTHDC2, YTH domain containing 2; HCV, hepatitis C virus; TNF-α, tumor necrosis; HCC, hepatocellular carcinoma; CRE, cAMP response element, HDAC, histone deacetylase; TSA, trichostatin A; CsA, cyc
NFκB mediates cisplatin resistance through histone modifications in head and neck squamous cell carcinoma (HNSCC)
Keywords: TSA، Trichostatin A; HNSCC; Chromatin remodeling; HDAC inhibitor; Histone acetylation; NFκB; ChemoresistanceHNSCC, head and neck squamous cell carcinoma; NFκB, nuclear factor kappa B; DDR, DNA damage repair; DSB, double strand breaks; TSA, trichostatin A; IKKα, IκB kinase alp
The activity of a novel mithramycin analog is related to its binding to DNA, cellular accumulation, and inhibition of Sp1-driven gene transcription
Keywords: TSA، Trichostatin A; DIG-MSK, demycarosyl-3D-β-d-digitoxosyl-mithramycin SK; MSK, mithramycin SK; MTA, mithramycin A; Sp1, specificity protein 1; Sp3, specificity protein 3; TSA, trichostatin A; ULBP1, UL16-binding protein 1Cell Uptake; DNA-binding; Mithramycin; Ovarian cance
SIRT1 is decreased during relapses in patients with multiple sclerosis
Keywords: TSA، Trichostatin A; MS, Multiple sclerosis; RR, Relapsing–remitting; HDAC3, Histone deacetylase 3; p-HDAC3, Phosphorylated histone deacetylase 3; SIRT1, Sirtuin 1; p-SIRT1, Phosphorylated sirtuin 1; EAE, Experimental autoimmune encephalomyelitis; TSA, Trichostatin A; CNS, Ce
Prenatal nicotinic exposure suppresses fetal adrenal steroidogenesis via steroidogenic factor 1 (SF-1) deacetylation
Keywords: TSA، Trichostatin A; StAR, steroidogenic acute regulatory; IUGR, intrauterine growth retardation; SF-1, steroidogenic factor-1; TSA, trichostatin A; HDACs, histone deacetylases; HPA, hypothalamic–pituitary–adrenal; CORT, corticosterone; P450scc, cholesterol side chain cleavag
Identification of Tf1 integration events in S. pombe under nonselective conditions
Keywords: TSA، Trichostatin A; TSA, trichostatin A; HDAC, histone deacetylase; IPCR, inverse polymerase chain reaction; G418, geneticin; neo, neomycinRetrotransposon; Integration; Heterochromatin; Fission yeast; Trichostatin A
Dual-acting histone deacetylase-topoisomerase I inhibitors
Keywords: TSA، Trichostatin A; HDAC, histone deacetylase; HAT, histone acetyltransferase; HDACi, histone deacetylase inhibitors; SAHA, suberoylanilide hydroxamic acid; TSA, trichostatin A; Topo I, topoisomerase I class of enzymesHistone deacetylase; Histone deacetylase inhibitors; Topo
Acetylation regulates Jun protein turnover in Drosophila
Keywords: TSA، Trichostatin A; TSA, trichostatin A; NAM, nicotinamide; HAT, histone acetyl transferase; HDAC, histone deacetylase; AP-1, activating protein 1Acetylation; Degradation; Jun; Phosphorylation
Epigenetic repression of miR-132 expression by the hepatitis B virus x protein in hepatitis B virus-related hepatocellular carcinoma
Keywords: TSA، Trichostatin A; HCC, hepatocellular carcinoma; HBx, hepatitis B virus x; miR-132, microRNA-132; DNMT3A, DNA methyltransferase 3A; UTR, untranslated region; MSP, methylation-specific PCR; Aza, 5-aza-2′-deoxycytidine; TSA, trichostatin A; GSTP1, glutathione S-transferase p
Nicotinamide treatment reduces the levels of histone H3K4 trimethylation in the promoter of the mper1 circadian clock gene and blocks the ability of dexamethasone to induce the acute response
Keywords: TSA، Trichostatin A; dex, dexamethasone; NAM, nicotinamide; TSA, trichostatin A; CHX, cycloheximide; SIRT1, sirtuin (silent mating type information regulator 2 homolog 1); PARP-1, poly(ADP-ribose) polymerase 1; H3K4me3, histone H3 trimethylated at lysine residue 4; SAMe, S-ad
Grape seed proanthocyanidins reactivate silenced tumor suppressor genes in human skin cancer cells by targeting epigenetic regulators
Keywords: TSA، Trichostatin A; GSPs, grape seed proanthocyanidins; DNMT, DNA methyltransferase; HDAC, histone deacetylase; H3-Lys 9, lysine 9 on histone H3; PCR, polymerase chain reaction; TSA, trichostatin A; 5-aza-dc, 5-aza-2′-deoxycytidineGrape seed proanthocyanidins; DNA methylatio
Impairment of p53 acetylation by EWS-Fli1 chimeric protein in Ewing Family Tumors
Keywords: TSA، Trichostatin A; EWS-Fli1; P53; Histone deacetylase 1EFTs, Ewing Family Tumors; siRNA, small interfering RNAs; HDAC1, histone deacetylase 1; TSA, trichostatin A; HDACi, HDAC inhibitor
MuLV IN mutants responsive to HDAC inhibitors enhance transcription from unintegrated retroviral DNA
Keywords: TSA، Trichostatin A; IN, Integrase; M-MuLV, Moloney murine leukemia virus; PIC, pre-integration complex; TSA, Trichostatin A; HDAC, histone deacetylaseNon-integrating vectors; Integrase; MuLV IN; HDAC inhibitors; Pre-integration complex, PIC; Intasome
Trichostatin A and sirtinol suppressed survivin expression through AMPK and p38MAPK in HT29 colon cancer cells
Keywords: TSA، Trichostatin A; HDAC, histone deacetylase; TSA, trichostatin A; AMPK, AMP-activated protein kinase; SIRT, sirtuin; IAP, inhibitor-of-apoptosis; ChIP, chromatin immunoprecipitationTrichostatin A; Sirtinol; Histone deacetylase; Survivin; Colon cancer
The Suv39H1 methyltransferase inhibitor chaetocin causes induction of integrated HIV-1 without producing a T cell response
Keywords: TSA، Trichostatin A; HIV-1, human immunodeficiency virus-1; H3K9, histone 3 lysine 9; HDAC, histone deacetylase; SAHA, suberoylanilide hydroxamic acid; TSA, trichostatin A; AIDS, acquired immunodeficiency syndrome; HAART, highly active anti retroviral therapyHIV-1; Latency; C
ERK1/2 activation plays important roles in the opposite effects of Trichostatin A in non-cancer and cancer cells
Keywords: TSA، Trichostatin A; HDAC inhibitor; TSA; Apoptosis; ERK1/2; Non-cancer cells; Cancer cellsHDAC, histone deacetylase; MAPK, mitogen-activated protein kinase; ERK1/2, extracellular signal-regulated kinase 1/2; TSA, trichostatin A; MEK1, MAPKK1, mitogen-activated protein kinase
The involvement of CHD5 hypermethylation in laryngeal squamous cell carcinoma
Keywords: TSA، Trichostatin A; 5-Aza-dC, 5-aza-2′-deoxycytidine; CHD5, chromodomain helicase DNA-binding protein 5; LSCC, laryngeal squamous cell carcinoma; mRNA, messenger RNA; PCR, polymerase chain reaction; TSA, trichostatin A; TSG, tumor suppressor geneCHD5; Hypermethylation; Laryn
SVEP1 promoter regulation by methylation of CpG sites
Keywords: TSA، Trichostatin A; CAM, Cell adhesion molecule; ECM, Extracellular matrix; ChIP, Chromatin immunoprecipitation; TF, Transcription factor; qPCR, quantitative PCR; MSP, Methylation-specific PCR; 5'aza-dC, 5’-aza-deoxycytidine; TSA, Trichostatin A; meDIP, Methylated DNA immuno
Structure-based optimization of click-based histone deacetylase inhibitors
Keywords: TSA، Trichostatin A; Histone deacetylase inhibitor; Click chemistry; Hydroxamic acid; Structure-based optimizationHDAC, histone deacetylase; SAHA, suberoylanilide hydroxamic acid; TSA, trichostatin A
Induction of TAp63 by histone deacetylase inhibitors
Keywords: TSA، Trichostatin A; HDAC, histone deacetylase; TSA, Trichostatin A; CTCL, cutaneous T-cell lymphoma; HATs, histone acetyl transferasesp63; HDAC inhibitors; TSA; LBH589; Apoptosis; Chemosensitivity; Cell death
VDR microRNA expression and epigenetic silencing of vitamin D signaling in melanoma cells
Keywords: TSA، Trichostatin A; 5-Aza, 5-azacytidine; DNMTI, DNA methyltransferase inhibitor; HDACI, histone deacetylase inhibitor; microRNA, micro messenger ribonucleic acid; mRNA, messenger ribonucleic acid; PCR, polymerase chain reaction; RXR, retinoid-X receptor; TSA, trichostatin A
Epigenetic regulation of caspase-3 gene expression in rat brain development
Keywords: TSA، Trichostatin A; CNS, central nervous system; BSA, bovine serum albumin; NSM, neuronal seeding medium; TSA, trichostatin A; PCR, polymerase chain reaction; RT, reverse transcription; GAPDH, glyceraldehyde-3-phosphate dehydrogenase; P, postnatal day; E, embryonic day; EDTA
Potential role of HDAC inhibitors in cancer therapy: Insights into oral squamous cell carcinoma
Keywords: TSA، Trichostatin A; CC, colorectal cancer; GC, gastric cancer; PC, prostate cancer; BC, breast cancer; TSA, trichostatin A; OSCC, oral squamous cell carcinoma; OED, oral epithelial dysplasia; HDACi, HDACs inhibitors; DMBA, 7,12-dimethylbenz[a]anthracene; SAHA, suberoylanilid
Regulation of Nur77 protein turnover through acetylation and deacetylation induced by p300 and HDAC1
Keywords: TSA، Trichostatin A; HAT, histone acetyltransferase; HDAC, histone deacetylase; IP, immunoprecipitation; TSA, trichostatin A; DBD, DNA-binding domain; LBD, ligand-binding domain; NGF, nerve growth factor; EGF, epithelial growth factor; PMA, phorbol myristate acetate; CHX, cyc
High content analysis of histone acetylation in human cells and tissues
Keywords: TSA، Trichostatin A; VPA, Valproic acid; HDACi, Histone deacetylase inhibitor; TSA, Trichostatin A; FBS, Foetal bovine serum; DMSO, Dimethyl sulfoxide; PBS-T, Phosphate buffered saline and Triton X-100; PVDF, Polyvinylidene difluoride membrane; ECL, Enhanced chemiluminescence
Liposomes loaded with histone deacetylase inhibitors for breast cancer therapy
Keywords: TSA، Trichostatin A; HDAC, histone deacetylase; HDACi, HDAC inhibitor; TSA, trichostatin A; ER, estrogen receptor; DSPE-PEG2000, 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-2000] (ammonium salt); ePC, egg phosphatidylcholine; Chol, choleste
DUSP26 negatively affects the proliferation of epithelial cells, an effect not mediated by dephosphorylation of MAPKs
Keywords: TSA، Trichostatin A; TSA, Trichostatin A; 5'AZA, 5-aza-2-deoxycitidine; DUSP, dual specificity phosphatase; PTP, protein tyrosine phosphatase; MAPK, mitogen-activated protein kinase; pNPP, p-nitrophenyl phosphate; GFP, green fluorescent proteinDual specificity phosphatase; Ph
The alternatively spliced murine pregnane X receptor isoform, mPXRΔ171–211 exhibits a repressive action
Keywords: TSA، Trichostatin A; PXR, pregnane X receptor; CYP, cytochrome P450; MDR1, Multi Drug Resistance Protein 1; P-gp, P-glycoprotein; TSA, trichostatin A; RXR, retinoid X receptor; NR, nuclear receptors; h, human; m, mouse; mRNA, messenger ribonucleic acid; mP1, mPXR431; mP2, mPX
PAH-Domain-Specific Interactions of the Arabidopsis Transcription Coregulator SIN3-LIKE1 (SNL1) with Telomere-Binding Protein 1 and ALWAYS EARLY2 Myb-DNA Binding Factors
Keywords: TSA، Trichostatin A; HDAC, histone deacetylase; Rb, retinoblastoma; PAH, paired amphipathic helix; HID, HDAC interaction domain; TBP1, telomere-binding protein 1; qRT-PCR, quantitative real-time PCR; TSA, trichostatin A; SID, selected interacting domain; SNL, SIN3-LIKE; ONPG,
Hepatitis B virus-X protein recruits histone deacetylase 1 to repress insulin-like growth factor binding protein 3 transcription
Keywords: TSA، Trichostatin A; HBV, hepatitis B virus; HBx, hepatitis B virus-X protein; IGFBP-3, insulin-like growth factor binding protein-3; HDAC1, histone deacetylase 1; IPP, immunoprecipitation; Chip, chromatin immunoprecipitation; TSA, trichostatin A; IGF-1, insulin-like growth f
Mechanism of apicidin-induced cell cycle arrest and apoptosis in Ishikawa human endometrial cancer cells
Keywords: TSA، Trichostatin A; HDAC, histone deacetylase; HATs, histone acetyltransferases; SAHA, suberoylanilide hydroxamic acid; DMSO, dimethyl sulfoxide; TSA, trichostatin A; DMEM, Dulbecco's Modified Eagle Medium; FBS, fetal bovine serum; PVDF, polyvinylidene difluoride; PI, propid
Trichostatin A sensitizes human ovarian cancer cells to TRAIL-induced apoptosis by down-regulation of c-FLIPL via inhibition of EGFR pathway
Keywords: TSA، Trichostatin A; EGFR, epidermal growth factor receptor; TSA, trichostatin A; HDACI, histone deacetylase inhibitor; PARP, poly(ADP-ribose) polymerase; ERK, extracellular signal-regulated kinase; TRAIL, tumor necrosis factor-related apoptosis-inducing ligand; DR4, death re
Structural and Functional Studies of the Yeast Class II Hda1 Histone Deacetylase Complex
Keywords: TSA، Trichostatin A; HDAC, histone deacetylase; TSA, trichostatin A; FL, full-length; FLC, full-length scHda1p–scHda2p–scHda3p complex; FLSC, full-length scHda2p–scHda3p sub-complex; DBD, DNA-binding domain; CCD, coiled-coil domain; ARB2, argonaute-binding protein 2; SEC, siz
Histone Deacetylases Regulate Multicellular Development in the Social Amoeba Dictyostelium discoideum
Keywords: TSA، Trichostatin A; HDAC, histone deacetylase; HAT, histone acetyltransferase; HMM, hidden Markov model; TSA, trichostatin A; RT-PCR, reverse transcription-polymerase chain reaction; HDAH, histone deacetylase-like amidohydrolase; HDLP, histone deacetylase-like proteinhistone
Down-regulation of Notch-dependent transcription by Akt in vitro
Keywords: TSA، Trichostatin A; NICD, Notch intracellular domain; dnAkt, dominant negative Akt; HDAC, histone deacetylase; TSA, trichostatin A; SMRT, silencing mediator of retinoid and thyroid hormone receptors; GSK3β, glycogen synthase kinase 3βAkt; NICD; Notch; Transcription
Relationship between the induction of leukemia cell differentiation and the enhancement of reporter gene expression in 3T3 Swiss cells
Keywords: TSA، Trichostatin A; DMSO, dimethylsulfoxide; HMBA, hexamethylene bisacetamide; Hyp, hypoxanthine; TGua, 6-thioguanine; TSA, trichostatin A; F-MEL, Friend murine erythroleukemia; HDAC, histone deacetylase; HAT, histone acetyltransferase; PMA, phorbol 12-myristate 13-acetate;
Effects of trichostatin A on neuronal mu-opioid receptor gene expression
Keywords: TSA، Trichostatin A; MOR, mu-opioid receptor; PCBP, poly C binding protein 1; ds, double-stranded; ss, single-stranded; TSA, trichostatin A; HDAC, histone deacetylase; HAT, histone acetyltransferase; CNS, central nervous system; ChIP, chromatin immunoprecipitation; Act D, act
Diet and the epigenetic (re)programming of phenotypic differences in behavior
Keywords: TSA، Trichostatin A; HAT, Histone acetyltransferase; HDAC, histone deacetylase; HMT, histone methyltransferase; DNMT, DNA methyltransferase; SAM, S-adenosylmethionine; HDACi, HDAC inhibitor; CBP, CREB binding protein; TSA, Trichostatin A; MBD2, METHYLATED DOMAIN DNA BINDING P
The oncoprotein gankyrin interacts with RelA and suppresses NF-κB activity
Keywords: TSA، Trichostatin A; NF-κB, nuclear factor-κB; HCC, hepatocellular carcinoma; LMB, leptomycin B; EMSA, electrophoretic mobility shift assay; TSA, trichostatin A; HDAC, histone deacetylasePSMD10; NF-κB; HSCO; Ankyrin; Histone deacetylase
Mrg15 null and heterozygous mouse embryonic fibroblasts exhibit DNA-repair defects post exposure to gamma ionizing radiation
Keywords: TSA، Trichostatin A; HAT, histone acetyltransferase; HDAC, histone deacetylase; IR, ionizing radiation; MEFs, mouse embryonic fibroblasts; MORF4, mortality factor on chromosome 4; MRG15, MORF4-related gene on chromosome 15; TSA, trichostatin A; het, heterozygousMORF4; NuA4; S
Antifibrogenic effects of histone deacetylase inhibitors on pancreatic stellate cells
Keywords: TSA، Trichostatin A; HDACI, histone deacetylase inhibitor; PSC, pancreatic stellate cell; VPA, sodium valproate; TSA, trichostatin A; BrdU, 5-bromo-2′-deoxyuridine; α-SMA, α-smooth muscle actin; ECM, extracellular matrix; HSC, hepatic stellate cell; PDGF, platelet-derived gro
Contribution of reactivated RUNX3 to inhibition of gastric cancer cell growth following suberoylanilide hydroxamic acid (vorinostat) treatment
Keywords: TSA، Trichostatin A; SAHA, suberoylanilide hydroxamic acid; HDAC, histone deacetylase; HAT, histone acetylase; TSA, trichostatin A; ChIP, chromatin immunoprecipitation; MBD, methyl-CpG binding domain; DNMT, DNA methyltransferase; 5-aza-CdR, 5-aza-2′-deoxycytidineVorinostat; R
Histone deacetylase inhibitor Trichostatin A induces global and gene-specific DNA demethylation in human cancer cell lines
Keywords: TSA، Trichostatin A; TSA, Trichostatin A; 5-azaCdR, 5-aza-deoxycytidine; HDACi, histone deacetylase inhibitor; HAT, histone acetyltransferase; DNMT, DNA methyltransferaseHistone deacetylase inhibitor; Tumor suppressor gene; DNA methylation; Histone acetylation; Hypomethylatio