Discovery and biological evaluation of potent, selective, orally bioavailable, pyrazine-based blockers of the Nav1.8 sodium channel with efficacy in a model of neuropathic pain
Keywords: TTx, tetrodotoxin; TTx-r, tetrodotoxin-resistant; VGSC, voltage gated sodium channels; DRG, dorsal root ganglia; ip, intraperitoneal; iv, intravenous; po, per os; F, bioavailability; T1/2, half-life; Clp, plasma clearance; CEREP, cell-surface receptors, i