Keywords: کسر نا محدود; HPLC (high-performance/pressure liquid chromatography); albumin; bioanalysis; antiinfectives; chelation; tetracycline; unbound fraction; patients; pH; calcium;
مقالات ISI کسر نا محدود (ترجمه نشده)
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Keywords: کسر نا محدود; ABC; ATP binding cassette; AMT; adsorptive-mediated transcytosis; BBB; blood-brain barrier; BCRP; breast cancer resistance protein; CE-MRI; contrast-enhanced magnetic resonance imaging; CNS; central nervous system; fu; unbound fraction; CT; computed tomog
Keywords: کسر نا محدود; voriconazole; pharmacokinetics; protein binding; unbound fraction; high-throughput technologies; equilibrium dialysis; albumin; α-1-acid-glycoprotein;
Keywords: کسر نا محدود; Lopinavir; Unbound fraction; Ultrafiltration; Nonspecific binding; UPLC–MS/MS
Extrapolation of the Hepatic Clearance of Drugs in the Absence of Albumin In Vitro to That in the Presence of Albumin In Vivo: Comparative Assessement of 2 Extrapolation Models Based on the Albumin-Mediated Hepatic Uptake Theory and Limitations and Mech
Keywords: کسر نا محدود; DMPK; hepatocytes; IVIVC; PBPK modeling; pharmacokinetics; unbound fraction;
High hepatic exposure of furanocoumarins in Radix Angelica dahuricae is associated with transporter mediated active uptake
Keywords: کسر نا محدود; ABT; 1-aminobenzotriazole; AUC0-â; area under the curve; BER; bergapten; Cmax; maximum plasma concentration; CsA; cyclosporine A; CYP; cytochrome P450; DMEM/F-12; Dulbecco's modified Eagle medium nutrient mixture F-12; DMSO; dimethyl sulfoxide; Æu; unb
Discovery of Novel and Potent Stearoyl Coenzyme A Desaturase 1 (SCD1) Inhibitors as Anticancer Agents
Keywords: کسر نا محدود; Ac; acetyl; ADME; absorption, distribution, metabolism, and excretion; aq.; aqueous; AUC; total area under the blood concentration-time curve; bid; bis in die (twice per day); Boc; (tert-butoxy)carbonyl; Bu; butyl; Bz; benzoyl; cLogP; calculate logarith
The molecular chaperone Hsp70 promotes the proteolytic removal of oxidatively damaged proteins by the proteasome
Keywords: کسر نا محدود; AMC; 7-amino-4-methylcoumarin; CL; Cross-linker; DNP; Dinitrophenyl; FRAP; Fluorescence recovery after photobleaching; GFP; Green fluorescent protein; Hsc70; Heat shock cognate protein 70 (also referred to as Hsp73); Hsp70; Heat shock protein 70 (also ref
Validation of a HPLC-MS/MS assay for the determination of total and unbound concentration of temocillin in human serum
Keywords: کسر نا محدود; Temocillin; HPLC-MS/MS; Serum concentration; Unbound fraction; Therapeutic drug monitoring
A Paradigm Shift in Pharmacokinetic-Pharmacodynamic (PKPD) Modeling: Rule of Thumb for Estimating Free Drug Level in Tissue Compared with Plasma to Guide Drug Design
Keywords: کسر نا محدود; ADME; unbound fraction; pharmacokinetics; pharmacodynamics; disposition; distribution; partition coefficients; PBPK; PKPD;
Hepatocyte Composition-Based Model as a Mechanistic Tool for Predicting the Cell Suspension: Aqueous Phase Partition Coefficient of Drugs in In Vitro Metabolic Studies
Keywords: کسر نا محدود; distribution; hepatocytes; liver; metabolism; metabolic clearance; unbound fraction; computational ADME; in vitro-in vivo extrapolation; IVIVE; pharmacokinetics; PBPK modeling;
Prediction of Total Hepatic Clearance by Combining Metabolism, Transport, and Permeability Data in the In Vitro-In Vivo Extrapolation Methods: Emphasis on an Apparent Fraction Unbound in Liver for Drugs
Keywords: کسر نا محدود; hepatocytes; intrinsic clearance; unbound fraction; metabolism; transport; permeability; in vitro-in vivo extrapolation; in vitro-in vivo correlation; IVIVE; pharmacokinetics; physiologically based pharmacokinetics; PBPK modeling;
Toward a new paradigm for the efficient in vitro–in vivo extrapolation of metabolic clearance in humans from hepatocyte data
Keywords: کسر نا محدود; hepatocytes; intrinsic clearance; unbound fraction; computational ADME; in vitro–in vivo extrapolation; in vitro–in vivo correlation; IVIVE; pharmacokinetics; physiologically based pharmacokinetics; PBPK modeling
Stereoselectivity in Pharmacokinetics of Rivoglitazone, A Novel Peroxisome Proliferator-Activated Receptor γ Agonist, in Rats and Monkeys: Model-Based Pharmacokinetic Analysis and In Vitro-In Vivo Extrapolation Approach
Keywords: کسر نا محدود; pharmacokinetics; protein binding; metabolic clearance; metabolism; distribution; chiral inversion; stereoselectivity; in vitro–in vivo extrapolation (IVIVE); unbound fraction; intrinsic clearance
Determination of unbound fraction of imatinib and N-desmethyl imatinib, validation of an UPLC–MS/MS assay and ultrafiltration method
Keywords: کسر نا محدود; Imatinib; N-desmethyl imatinib; Unbound fraction; Ultrafiltration; UPLC–MS/MS
Advancing Prediction of Tissue Distribution and Volume of Distribution of Highly Lipophilic Compounds from a Simplified Tissue-Composition-Based Model as a Mechanistic Animal Alternative Method
Keywords: کسر نا محدود; animal alternative; ADME; disposition; distribution; volume of distribution; pharmacokinetics; protein binding; unbound fraction; PBPK; first-time-in-human;
In Vitro-In Vivo Extrapolation of Clearance: Modeling Hepatic Metabolic Clearance of Highly Bound Drugs and Comparative Assessment with Existing Calculation Methods
Keywords: کسر نا محدود; disposition; microsomes; hepatic clearance; metabolic clearance; unbound fraction; computational ADME; in vitro-in vivo extrapolation; IVIVE; pharmacokinetics; PBPK modeling;
Comparative Assessment of In Vitro-In Vivo Extrapolation Methods used for Predicting Hepatic Metabolic Clearance of Drugs
Keywords: کسر نا محدود; disposition; microsomes; clearance; unbound fraction; computational ADME; in vitro-in vivo extrapolation; in vitro-in vivo correlation; IVIVE; pharmacokinetics; PBPK modeling;
Lipophilicity study of some non-steroidal anti-inflammatory agents and cephalosporin antibiotics: A review
Keywords: کسر نا محدود; 13C NMR; carbon nuclear magnetic resonance; 1H NMR; proton nuclear magnetic resonance; ADME; absorption distribution metabolism elimination; AID; adjuvant induced disease; AUC; plasma-time curve; BBB; blood-brain barrier; BMC; biopartitioning micellar
Microsome composition-based model as a mechanistic tool to predict nonspecific binding of drugs in liver microsomes
Keywords: کسر نا محدود; distribution; microsomes; clearance; metabolism; metabolic clearance; unbound fraction; computational ADME; in vitro-in vivo extrapolation; IVIVE; pharmacokinetics; PBPK modeling;
Quantitative determination of total and unbound paclitaxel in human plasma following Abraxane treatment
Keywords: کسر نا محدود; Albumin; Nanoparticle; Paclitaxel; Taxane; Anticancer; Formulation; LC–MS/MS; Unbound fraction; Free fraction
Reproducible and time-dependent modification of serum protein binding in Wistar Kyoto rats
Keywords: کسر نا محدود; α1-acid glycoprotein; AGP; Free fraction, methods; Rat serum albumin; RSA; Serum protein binding; S(−)-Propranolol; Unbound fraction