Keywords: مدل رو به زوال; AAG; α1-acid glycoprotein; IPRL; isolated perfused rat liver; IVIVE; in vitro-in vivo extrapolation; PBPK; physiologically based pharmacokinetic(s); PK; pharmacokinetic(s); Pharmacokinetics; Well-stirred model; Parallel-tube model; Dispersion model; Hepa
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Keywords: مدل رو به زوال; Pharmacokinetics; Analogy; Well-stirred model;
Inhibition of cytochrome P450 enzymes by saturated and unsaturated fatty acids in human liver microsomes, characterization of enzyme kinetics in the presence of bovine serum albumin (0.1 and 1.0% w/v) and in vitro - in vivo extrapolation of hepatic clea
Keywords: مدل رو به زوال; Fatty acids; CYP450 enzymes; Enzyme inhibition; Michaelis-Menten kinetics; Bovine serum albumin (BSA); Intrinsic clearance; Well-stirred model; Hepatic clearance; In vitro - In vivo extrapolation (IVIVE);
Exploration of PBPK Model-Calculation of Drug Time Course in Tissue Using IV Bolus Drug Plasma Concentration-Time Profile and the Physiological Parameters of the Organ
Keywords: مدل رو به زوال; tissue partitioning; partition coefficient; physiological model; well-stirred model; distribution; linear pharmacokinetics;
The Corrected Traditional Equations for Calculation of Hepatic Clearance that Account for the Difference in Drug Ionization in Extracellular and Intracellular Tissue Water and the Corresponding Corrected PBPK Equation
Keywords: مدل رو به زوال; hepatic clearance; well-stirred model; parallel tube model; dispersion model; drug ionization; extra- and intracellular water distribution; physiological model; PBPK equation; hepatic uptake and efflux; metabolic elimination; pharmacokinetics;
A Valid Equation for the Well-Stirred Perfusion Limited Physiologically Based Pharmacokinetic Model that Consistently Accounts for the Blood-Tissue Drug Distribution in the Organ and the Corresponding Valid Equation for the Steady State Volume of Distribu
Keywords: مدل رو به زوال; physiologically based pharmacokinetic model; perfusion limited model; well-stirred model; perfusion volume; tissue-plasma partition coefficient; blood-plasma concentration ratio; steady state volume of distribution; clearance;
On the prediction of hepatic clearance using the diluted plasma in metabolic stability assay
Keywords: مدل رو به زوال; hepatic clearance; intrinsic clearance; metabolic stability; protein binding; microsomal binding; well-stirred model; pharmacokinetics;
Prediction of the possibility of the secondary peaks of iv bolus drug plasma concentration time curve by the model that directly takes into account the transit time through the organ
Keywords: مدل رو به زوال; secondary peaks; clearance; transit time; mathematical model; parallel tube model; well-stirred model; pharmacokinetics;