Antibodies to proteinase 3 prime human monocytic cells via protease-activated receptor-2 and NF-κB for Toll-like receptor- and NOD-dependent activation
Keywords: ANCA, anti-neutrophil cytoplasmic antibodies; PR3, proteinase 3; WG, Wegener's granulomatosis; MCP-1, monocyte chemoattractant protein-1; PAR, protease-activated receptor; PRRs, pattern recognition receptors; PAMPs, pathogen-associated molecular patterns;