Effects of PI3K inhibition and low docosahexaenoic acid on cognition and behavior
Keywords: ورتمنین; PI3-kinase; Wortmannin; Docosahexaenoic acid; Alzheimer's disease; Diabetes
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Akt and phosphoinositide regulation and wortmannin-dependent induction of phospho-Akt in 3T3-L1 adipocytes on cold exposure followed by rewarming
Keywords: ورتمنین; Akt; Cold; PI 3,4,5-trisphosphate; Rewarming; 3T3-L1 adipocytes; Wortmannin
Cell context-dependent involvement of ATR in early stages of retroviral replication
Keywords: ورتمنین; PIKK; ATR; ATM; DNA repair; Integration; Retroviral replication; Caffeine; Wortmannin; Antiviral chemotherapy
Wortmannin potentiates roscovitine-induced growth inhibition in human solid tumor cells by repressing PI3K/Akt pathway
Keywords: ورتمنین; Roscovitine; Wortmannin; A549 cells; Apoptosis; PI3K/Akt
Suppression of zinc-induced p53 phosphorylation and p21 expression by wortmannin in A549 human pulmonary epithelial cells
Keywords: ورتمنین; Zinc; p53; p21; Wortmannin; A549 cells;
Regulation of pancreatic duct cell differentiation by phosphatidylinositol-3 kinase
Keywords: ورتمنین; PDX-1; PI3K; Insulin; Pancreatic regeneration; Duct differentiation; β-Cell differentiation; Wortmannin; siRNA;
TNFα is a potent inducer of platelet-activating factor synthesis in adipocytes but not in preadipocytes. Differential regulation by PI3K
Keywords: ورتمنین; TNFα; PAF; Adipocytes; Wortmannin; Obesity
Endosomal colocalization of melanocortin-3 receptor and β-arrestins in CAD cells with altered modification of AKT/PKB
Keywords: ورتمنین; AKT/PKB; Arrestins; Cell proliferation; Endocytosis; MC3R; Melanocortin; Triciribine; Wortmannin; Ubiquitin
Immune responses of mussel hemocyte subpopulations are differentially regulated by enzymes of the PI 3-K, PKC, and ERK kinase families
Keywords: ورتمنین; Mollusc; Signal transduction; Innate immunity; Phagocytosis; Respiratory burst; Wortmannin; Staurosporine; PD98059; Professional phagocytes
Targeting the PI3K/Akt/mTOR pathway: Effective combinations and clinical considerations
Keywords: ورتمنین; PI3 kinase; Akt; Combination; Chemotherapy; Cancer; Wortmannin; PX-866; Perfosine; mTOR inhibitors; Rapamycin; RAD-001; PI-103; Triciribine (API-2)
Positive regulation of tumor necrosis factor-α by ganglioside GM3 through Akt in mouse melanoma B16 cells
Keywords: ورتمنین; PBS(-), phosphate-buffered saline without Ca and Mg cations; HPTLC, high performance thin layer chromatographyGanglioside GM3; TNFα; PI3K; Akt; LY294,002; Wortmannin
Crucial role of cytoskeleton reorganization in the negative inotropic effect of chromogranin A-derived peptides in eel and frog hearts
Keywords: ورتمنین; Vasostatins; Heart preparations; Cytochalasin-D; Wortmannin; BDM; W7
Mixed polymeric micelles for combination cancer chemotherapy through the concurrent delivery of multiple chemotherapeutic agents
Keywords: ورتمنین; Mixed polymeric micelle; Controlled drug delivery; Combination chemotherapy; Doxorubicin; Wortmannin
Activation of Telomerase by Ionizing Radiation: Differential Response to the Inhibition of DNA Double-Strand Break Repair by Abrogation of Poly(ADP-ribosyl)ation, by LY294002, or by Wortmannin
Keywords: ورتمنین; Telomerase; Irradiation; Double-strand breaks; LY294002; Wortmannin;
A role for Rab5 activity in the biogenesis of endosomal and lysosomal compartments
Keywords: ورتمنین; Rab5; Endosomes; Lysosomes; Ptdlns (3)-kinase; Wortmannin; Hybrid organelle; Lysosome biogenesis
Insulin Attenuates Apoptosis and Exerts Anti-Inflammatory Effects in Endotoxemic Human Macrophages
Keywords: ورتمنین; insulin; apoptosis; macrophage; endotoxemia; sepsis; phopsphatidylinositol-3-kinase; wortmannin; inflammation
Zinc-induced downregulation of Notch signaling is associated with cytoplasmic retention of Notch1-IC and RBP-Jk via PI3k–Akt signaling pathway
Keywords: ورتمنین; Notch intracellular domain; RBP-Jk; Zinc; Phosphatidylinositol 3-kinase; Akt; Cytoplasmic retention; Wortmannin; LY294002
PI3K-Akt inactivation induced CHOP expression in endoplasmic reticulum-stressed cells
Keywords: ورتمنین; Endoplasmic reticulum stress; PI3K-Akt pathway; LY294002; Wortmannin; PD98059; CHOP
A chemiluminescence-based reporter system to monitor nonsense-mediated mRNA decay
Keywords: ورتمنین; Nonsense-mediated mRNA decay; Reporter assay; UPF1 phosphorylation; Chemical biology; Luciferase; Wortmannin
Sennidin stimulates glucose incorporation in rat adipocytes
Keywords: ورتمنین; Insulin; Insulin mimetic; Oriental medical plant; Sennidin; Glucose transport; Wortmannin; Akt; Glucose transporter 4
PI3K is required for insulin-stimulated but not EGF-stimulated ERK1/2 activation
Keywords: ورتمنین; Extracellular signal-regulated kinase 1 and 2; Phosphatidylinositol 3-kinase; Insulin; Epidermal growth factor; Ras; Akt; Wortmannin; LY294002; Protein kinase C; Phorbol 12-myristate 13-acetate
Wortmannin delays transfer of human rhinovirus serotype 2 to late endocytic compartments
Keywords: ورتمنین; Picornaviruses; Human rhinoviruses; Minor receptor group; HeLa cells; Wortmannin; Phosphatidylinositol 3-kinases; Endocytosis
Anaesthetic sensitivity of fMLP-induced cell signalling in Xenopus oocytes
Keywords: ورتمنین; Thiopentone; Methohexitone; Propofol; Heparin; U73122; Wortmannin;
Entamoeba histolytica: FYVE-finger domains, phosphatidylinositol 3-phosphate biosensors, associate with phagosomes but not fluid filled endosomes
Keywords: ورتمنین; Adhesion; Amoeba; Endocytosis; Entamoeba histolytica; FYVE-finger domain; LY 294002; Phagocytosis; Phosphatidylinositol 3-kinase; Phosphatidylinositol 3-phosphate; Pinocytosis; Wortmannin; DMSO, dimethylsulfoxide; EEA1, early endosome antigen 1; EhPAK, p2
Wortmannin induces zebrafish cardia bifida through a mechanism independent of phosphoinositide 3-kinase and myosin light chain kinase
Keywords: ورتمنین; Cardia bifida; Zebrafish; Wortmannin; Chemical genetics;
Geniposide activates GSH S-transferase by the induction of GST M1 and GST M2 subunits involving the transcription and phosphorylation of MEK-1 signaling in rat hepatocytes
Keywords: ورتمنین; GST; GSH S-transferase; MEK-1; extracellular-regulated kinase kinase-1; PI 3-K; phosphotidyl inositol 3-kinase; PD; PD98059; SP; SP600125; SB; SB203580; Wt; wortmannin; ARE; antioxidant-responsive element; CDNB; 1-chloro-2, 4-dinitrobenzene; GAPDH; glycer
Wortmannin inhibits the myofilament Ca2+ sensitization induced by endothelin-1
Keywords: ورتمنین; Inotropic effect; Ca2+ transient; Endothelin-1; Wortmannin; Rabbit cardic myocyte;
Effect of Wortmannin on the repair profiles of DNA double-strand breaks in the whole genome and in interstitial telomeric sequences of Chinese hamster cells
Keywords: ورتمنین; DBD-FISH; Comet assay; Interstitial telomeric sequences; DNA breaks; DNA repair; Wortmannin;
D-3 phosphoinositides of the ciliate Tetrahymena: Characterization and study of their regulatory role in lysosomal enzyme secretion
Keywords: ورتمنین; PtdIns; phosphatidylinositol; PI; phosphoinositide; PtdInsP; phosphatidylinositol phosphate; PtdInsP2; phosphatidylinositol bisphosphate; PtdIns(3)P; phosphatidylinositol 3-phosphate; PtdIns(4)P; phosphatidylinositol 4-phosphate; PtdIns(3,5)P2; phosphatid
PDGF activates K-Cl cotransport through phosphoinositide 3-kinase and protein phosphatase-1 in primary cultures of vascular smooth muscle cells
Keywords: ورتمنین; K-Cl cotransport; Platelet-derived growth factor; Signal transduction; Phosphoinositide 3-kinase (PI 3-K); Protein phosphatase-1 (PP-1); Wortmannin; LY294002; Vascular smooth muscle;