Keywords: نوع وحشی; IR, ionizing radiation; LC, liquid chromatography; MS, mass spectrometry; TCA, tricarboxylic acid; WT, wild type; CT, computed tomography; PARP1, poly(ADP-ribose)polymerase 1; BER, base excision repair; SIRT1, sirtuin-1; D1, day 1; D3, day 3; HMDB, the Hu
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Keywords: نوع وحشی; WT, wild type; FCCP, carbonylcyanide-p-trifluoromethoxyphenylhydrazone; CRU, Calcium Release Unit; CTRL, control; ER/SR, endoplasmic/sarcoplasmic reticulum; FDB, flexor digitorum brevis; KD, knockdown; MCU, mitochondrial Ca2+ uniporter; Mfn1/2, Mitofusin
Keywords: نوع وحشی; Antipsychotic drugs; Multi-target; Binding profile; GPCR; Site-directed mutagenesis; Molecular modellingGPCRs, G protein-coupled receptors; TM5, transmembrane helix 5; WT, wild type
Keywords: نوع وحشی; As, arsenic; Het, heterozygote; wt, wild type; Null, nullizygote; Mthfr, 5,10-methylenetetrahydrofolate reductase; neo allele, Mthfr gene allele with inserted neo cassette (containing neomycin resistance gene)Sodium arsenate; 5,10-Methylenetetrahydrofolat
Keywords: نوع وحشی; MPTP, mitochondrial permeability transition pore; CYPD, cyclophilin D; HFD, high fat diet; LFD, low fat diet; WT, wild type; KO, knockout; CSA, cyclosporin A; BKA, bongkrekic acid; O2, superoxide; [3H]-2-DOG, [3H]-2-deoxyglucose; Rg′, rate of glucose tran
Keywords: نوع وحشی; Adenovirus; Brain tumor; Glioma; Self-replicated vector; Stem cellsGBM, glioblastoma multiforme; Ad, Adenovirus; DNA, Deoxyribonucleic Acid; RNA, Ribonucleic acid; Wt, wild type; CSC, Cancer stem cells; GSC, Glioma stem cells; IFN, interferon; FACS, Fluor
Keywords: نوع وحشی; HFD, high-fat diet; PXR, pregnane X receptor; mPXR, mouse PXR; hPXR, PXR-humanized or human PXR; WT, wild type; WAT, white adipose tissue; BAT, brown adipose tissue; ALT, alanine transaminase; PPARs, peroxisome proliferator-activated receptors; LBD, ligan
Keywords: نوع وحشی; ERK, extracellular signal-regulated kinase; GTP, guanosine triphosphate; MAPK, mitogen-activated protein kinase; NF1, neurofibromatosis type 1; WT, wild type
Keywords: نوع وحشی; WT, wild type; Tg, transgenic; pSTR, positive scotopic threshold response; ERG, electroretinogram; IOP, intraocular pressure; GCL, ganglion cell layer; IPL, inner plexiform layer; AD, Alzheimer’s disease; APP, amyloid precursor protein; PSEN, presenilineA
Keywords: نوع وحشی; EBF2; Beige fat; Brown fat; Obesity; ThermogenesisBAT, brown adipose tissue; WAT, white adipose tissue; ingWAT, inguinal white adipose tissue; epiWAT, epididymal white adipose tissue; WT, wild type; TG, transgenic; HFD, high fat diet; TN, thermoneutrality
Keywords: نوع وحشی; IF, intermediate filament; NSCs, neural stem cells; NPCs, neural progenitor cells; E8.5, embryonic day 8.5; WT, wild type; TG, transgenic; PI3K, phosphoinositide 3-kinaseNestin; Embryonic development; Heart; Forebrain; Cell proliferation; PI3K/Akt pathway
Involvement of TLR6 in the induction of COX-2, PGE2 and IL-10 in macrophages by lipids from virulent S2P and attenuated R1A Babesia bovis strains
Keywords: نوع وحشی; WT, wild type; TLR6KO, toll like receptor 6 knockout; LA, total lipids of B. bovis attenuated strain; LV, total lipids of B. bovis virulent strain; COX-2, cyclooxygenase; PGE2, prostaglandin E2Lipids; Babesia bovis; TLR6; Macrophages
Data of the molecular dynamics simulations of mutations in the human connexin46 docking interface
Keywords: نوع وحشی; CL, cytoplasmic loop; Cx, connexin; DOPE, discrete optimized protein energy; E2, second extracellular loop; HB, hydrogen bond; hCx, human connexin; MD, molecular dynamics; SCAM, substituted cysteine accessibility method; wt, wild type
Molecular modeling, mutational analysis and conformational switching in IL27: An in silico structural insight towards AIDS research
Keywords: نوع وحشی; WT, wild type; MT_G, mutant type with glycine; MT_A, mutant type with alanine; MD, molecular dynamicsIL-27; Molecular modeling; Mutation; Molecular dynamics simulations; AIDS; Biostatistics
NQO1 rs1800566 polymorph is more prone to NOx induced lung injury: Endorsing deleterious functionality through informatics approach
Keywords: نوع وحشی; WT, Wild type; NQO1, NAD(P)H:quinone oxidoreductase 1; RMSD, Root mean square deviation; CUPSAT, Cologne University Protein Stability Analysis Tool; ΔΔG, unfolding energy; PDB, Protein data bank; MOE, Molecular Operating Environment; NPA, Nosé-Poincaré-An
Osteopontin plays a key role in vascular smooth muscle cell proliferation via EGFR-mediated activation of AP-1 and C/EBPβ pathways
Keywords: نوع وحشی; VSMC, vascular smooth muscle cell; OPN, osteopontin; HNE, 4-hydroxynonenal; WT, wild type; EGFR, epidermal growth factor receptor; PDGFR, platelet-derived growth factor receptor; ChIP, chromatin immunoprecipitation; RTK, receptor tyrosine kinases; PCNA, p
A critical role for alpha-synuclein in development and function of T lymphocytes
Keywords: نوع وحشی; KO, knock-out; WT, wild type; PD, Parkinson’s disease; APC, antigen presenting cell; TCR, T cell receptor; MHC, major histocompatibility complex; DN, double negative; DP, double positive; SP, single positiveα-Synuclein; CD4; CD8; T cells; Treg; Lymphopoie
Large scale analysis of the mutational landscape in β-glucuronidase: A major player of mucopolysaccharidosis type VII
Keywords: نوع وحشی; LSD, lysosomal storage disease; MPSVII, mucopolysaccharidosis type VII; MD, molecular dynamics; GUSB, β-glucuronidase; WT, wild type; RMSD, root mean square deviations; RMSF, root mean square fluctuations; Rg, radius of gyration; ns, nano secondLysosomal
IL36RN Mutations Affect Protein Expression and Function: A Basis for Genotype-Phenotype Correlation in Pustular Diseases
Keywords: نوع وحشی; GPP, generalized pustular psoriasis; IL-1Rrp2, IL-1 receptor-related protein–2; IL-36Ra, interleukin-36 receptor antagonist; PsV, psoriasis vulgaris; WT, wild type
CsWRKY46, a WRKY transcription factor from cucumber, confers cold resistance in transgenic-plant by regulating a set of cold-stress responsive genes in an ABA-dependent manner
Keywords: نوع وحشی; Abiotic stress; Abscisic acid; Cucumber; Transcription factor; Transgenic plantsABA, abscisic acid; CsWRKY46, Cucumis sativus group II WRKY transcription factor; MDA, malondialdehyde; WRKY46-OE, CsWRKY46 overexpression transgenic line; WT, wild type
Expression of Evc2 in craniofacial tissues and craniofacial bone defects in Evc2 knockout mouse
Keywords: نوع وحشی; EvC, Ellis-van Creveld; EVC2, Ellis-van Creveld 2; WT, wild type; KO, knockout; Het, heterozygous; IRES, internal ribosomal entry site; β-gal, β-galactosidase; IHC, immunohistochemistry; Hh, hedgehog; Smo, Smoothened; Ptch1, Patched1; SuFu, suppressor of
Length-dependent axo-terminal degeneration at the neuromuscular synapses of type II muscle in SOD1 mice
Keywords: نوع وحشی; ALS, amyotrophic lateral sclerosis; CMAP, compound muscle action potential; CMM, cutaneous maximus muscle; LTN, lateral thoracic nerve; NMJs, neuromuscular junctions; PBS, Phosphate-buffered saline; SOD1, superoxide dismutase 1; WT, wild type; YEP, Yellow
Ectopic expression of a grape aspartic protease gene, AP13, in Arabidopsis thaliana improves resistance to powdery mildew but increases susceptibility to Botrytis cinerea
Keywords: نوع وحشی; AP, aspartic protease; SA, Salicylic acid; JA, jasmonic acid; ET, ethylene; SAR, systemic acquired resistance; PR, pathogenesis-related; MeJA, methyl jasmonate; WT, wild type; PstDC3000, Pseudomonas syringae pv. tomato DC3000; pad4, Phytoalexin deficient
Inactivation of the conserved open reading frame ycf34 of Synechocystis sp. PCC 6803 interferes with the photosynthetic electron transport chain
Keywords: نوع وحشی; WT, wild type; ycf, hypothetical chloroplast open reading frame; CPRENDO, chloroplast proteins of endosymbiotic origin; ORF, open reading frame; PpBQ, phenyl-p-benzoquinone; β-DM, n-dodecyl-β-maltoside; PS I, photosystem I; PS II, photosystem II; PQ, plas
Transcriptomic analysis of Arabidopsis overexpressing flowering locus T driven by a meristem-specific promoter that induces early flowering
Keywords: نوع وحشی; wt, wild type; FT, Flowering locus T; AtFTOE, Arabidopsis FT-overexpressor lines; SOC1, SUPPRESSOR OF OVEREXPRESSION OF CONSTANS 1; SAM, shoot apical meristem; LD, long days; SD, short days; TSF, TWIN SISTER OF FT; CC, companion cell; FUL, FRUITFULL; AP1,
Structure/Function Relations in AIFM1 Variants Associated with Neurodegenerative Disorders
Keywords: نوع وحشی; AIF, apoptosis-inducing factor; CTC, charge-transfer complex; OXPHOS, oxidative phosphorylation; Mia40, mitochondrial intermembrane space import and assembly 40; WT, wild type; HT, hydride transfer; DCIP, dichlorophenolindophenol; AIFred, 2-electron reduc
Protein–RNA Dynamics in the Central Junction Control 30S Ribosome Assembly
Keywords: نوع وحشی; rRNA, ribosomal RNA; smFRET, single-molecule Förster or fluorescence resonance energy transfer; PCR, polymerase chain reaction; WT, wild type; WC, Watson–Crick; GFP, green fluorescent protein; rprotein, ribosomal protein16S rRNA; ribosome protein S15; RNA
The spectrum of MEFV gene mutations and genotypes in Van province, the eastern region of Turkey, and report of a novel mutation (R361T)
Keywords: نوع وحشی; FMF, familial Mediterranean fever; MEFV, Mediterranean fever gene; SD, standard deviation; wt, wild type; LD, linkage disequilibriumFamilial Mediterranean fever; MEFV; R361T; c.1082G>C; Allelic frequencies; Novel mutation
Expression of nhaA gene confers salt-sensitivity in transgenic rice cultures and plants
Keywords: نوع وحشی; T0, first generation of transformed plants; T1, offspring from T0 plants; WT, wild type; GFP, green fluorescence protein; qRT-PCR, real-time quantitative polymerase chain reaction; PMI, phosphomannose isomerase; Escherichia coli, E. coli; Saccharomyces ce
Phosphomimicking within the transit peptide of pHCF136 leads to reduced photosystem II accumulation in vivo
Keywords: نوع وحشی; HCF, high chlorophyll fluorescence; PS, photosystem; HSP, heat shock protein; SSU, ribulose-15-bisphosphate carboxylase/oxygenase; Cyt, cytochrome; WT, wild type; BN, Blue Native; LHC, light harvesting complex; β-DM, β-dodecyl-maltosideChloroplast; Protei
Lentivirus mediated over expression of CGRP inhibited oxidative stress in Schwann cell line
Keywords: نوع وحشی; CGRP, calcitonin gene related peptide; WT, wild type; NG, normal glucose; HG, high glucose; SOD, superoxide dismutase; MDA, malondialdehyde; NOX, nicotinamide-adenine dinucleotide phosphate oxidaseCGRP; Schwann cell; Oxidative stress
Thrombin-induced reactive oxygen species generation in platelets: A novel role for protease-activated receptor 4 and GPIbα
Keywords: نوع وحشی; ROS, reactive oxygen species; Nk, Naja kaouthia protease; CRP, collagen-related peptide; WT, wild type; PAR, protease-activated receptorPlatelets; Reactive oxygen species; Thrombin; Receptors GPIbα; PAR1 and PAR4
Stage-specific control of stem cell niche architecture in the Drosophila testis by the posterior Hox gene Abd-B
Keywords: نوع وحشی; Abd-B, abdominal-B; CySCs, somatic cyst stem cells; ECM, extracellular matrix; GSCs, germline stem cells; SCCs, somatic cyst cells; SGPs, somatic gonadal precursors; wt, wild type; L3, 3rd instar Drosophila larvaeAbd-B; Drosophila testis; Integrin; Talin;
Hyaluronan ameliorates LPS-induced acute lung injury in mice via Toll-like receptor (TLR) 4-dependent signaling pathways
Keywords: نوع وحشی; TLR4, Toll-like receptor-4; ALI, acute lung injury; HA, hyaluronan; LPS, lipopolysaccharide; BALF, bronchial alveolar lavage fluid; WT, wild type; NF-κB, nuclear factor κB; MyD88, Myeloid differentiation primary response protein; HMW-HA, High molecular we
Characterization of G protein coupling mediated by the conserved D1343.49 of DRY motif, M2416.34, and F2516.44 residues on human CXCR1
Keywords: نوع وحشی; CXCR1, CXC receptor 1; GPCR, G protein-coupled receptor; DRY motif, Asp-Arg-Tyr motif; IL-8, interleukin 8; TMs, transmembrane domain; i2, intracellular loop 2; i3, intracellular loop 3; PLC, phospholipase C; WT, wild type; Kd, affinity constants; IP, ino
Functional Beta2-Integrins Restrict Skin Inflammation In Vivo
Keywords: نوع وحشی; DC, dendritic cell; KI, knock in; KO, knock out; LAD-1, leukocyte adhesion deficiency type I; LN, lymph node; OXA, oxazolone; WT, wild type
Heterologous expression of EsSPDS1 in tobacco plants improves drought tolerance with efficient reactive oxygen species scavenging systems
Keywords: نوع وحشی; WT, Wild type; ABA, Abscisic acid; SOD, Superoxide dismutase; CAT, Catalase; qRT-PCR, Quantitative reverse transcription polymerase chain reactionEutrema salsugineum; EsSPDS1; Polyamine; Spermidine synthase; Drought tolerance; Transgenic tobacco
The Antitumorigenic Function of EGFR in Metastatic Breast Cancer is Regulated by Expression of Mig6
Keywords: نوع وحشی; Mig6, mitogen-induced gene-6; BC, breast cancer; EGFR, epidermal growth factor receptor; Mig6-EBR, EGFR binding region of Mig6; TGF-β, transforming growth factor-β; WT, wild type; NMuMG, normal murine mammary gland cells; NME, NMuMG cells transformed by E
Deciphering metabolic abnormalities associated with Alzheimer's disease in the APP/PS1 mouse model using integrated metabolomic approaches
Keywords: نوع وحشی; Metabolomics; APP/PS1 mice; Alzheimer's disease; SerumAD, Alzheimer's disease; GC–MS, gas chromatography mass spectrometry; UHPLC-MS, ultra-high performance liquid chromatography mass spectrometry; TG, transgenic; WT, wild type; QC, quality control; PCA,
Recovery of the wild type atomic flexibility in the HIV-1 protease double mutants
Keywords: نوع وحشی; Molecular modeling; Normal modes analysis; HIV-1 protease; Double mutants; Protein flexibilityPIs, protease inhibitors; WT, wild type; h-bond, hydrogen bond; HIV-1, Human Immunodeficiency virus type-1; RMSF, root mean square fluctuations
The bacteriocin AS-48 requires dimer dissociation followed by hydrophobic interactions with the membrane for antibacterial activity
Keywords: نوع وحشی; WT, wild type; MIC, minimal inhibitory concentration; CD, circular dichroism; PC, phosphatidylcholine; PS, phosphatidylserineBacteriocin; Antimicrobial peptide; Membrane bilayer; Lipid binding protein; X-ray crystallography
Obesity in a model of gpx4 haploinsufficiency uncovers a causal role for lipid-derived aldehydes in human metabolic disease and cardiomyopathy
Keywords: نوع وحشی; Glutathione peroxidase 4; Lipid peroxidation; Obesity; Mitochondria; Inflammation; Human heartPUFA, polyunsaturated fatty acids; LPPs, lipid peroxidation end products; GPx4, glutathione peroxidase 4; HFHS, high fat, high sucrose; WT, wild type; CNTL, cont
Sparing of the extraocular muscles in mdx mice with absent or reduced utrophin expression: A life span analysis
Keywords: نوع وحشی; Extraocular muscle; Muscular dystrophy; Satellite cell; MyoD; Pax7; UtrophinEOM, extraocular muscle; WT, wild type
A fruitful endeavor: Modeling ALS in the fruit fly
Keywords: نوع وحشی; ALS, amyotrophic lateral sclerosis; OMIM, Online Mendelian Inheritance in Man; SOD1, superoxide dismutase; FALS, familial ALS; SALS, sporadic ALS; WT, wild type; dSOD1, Drosophila SOD1; hSOD1, human SOD1; BMAA, β-N-methylamino-l-alanine; Rab5, Ras-related
Liver transcript analysis reveals aberrant splicing due to silent and intronic variations in the ABCB11 gene
Keywords: نوع وحشی; ABCB11, ATP-binding cassette, sub-family B (MDR/TAP), member 11; BSEP, bile salt export pump; PFIC2, progressive familial intrahepatic cholestasis type 2; SNPs, single-nucleotide polymorphisms; ESE, exonic splicing enhancer; WT, wild type; ss, splice site
E3-ligase Skp2 regulates β-catenin expression and maintains hematopoietic stem cell homing
Keywords: نوع وحشی; Skp2, S-phase kinase associated protein2; HSC, hematopoietic stem cells; BM, bone marrow; WT, wild type; BSA, Bovine Serum Albumin; DAPI, 4′,6-diamidino-2-phenylindole; CFSE, carboxyfluorescein succinimidyl ester; LT-HSC, Lineage-Sca-1+c-Kit+Flk-CD34-; LS
Design of non-aggregating variants of Aβ peptide
Keywords: نوع وحشی; Aβ, amyloid-β peptide; AD, Alzheimer’s disease; wt, wild type; NGF, nerve-growth factor; ThT, thioflavin TAmyloid beta; Alzheimer’s disease; Non-aggregating mutations
A novel mechanism for activation of Aurora-A kinase by Ajuba
Keywords: نوع وحشی; aa, amino acid(s); cDNA, DNA complementary to RNA; kDa, kilodalton(s); wt, wild type; PMSF, phenylmethylsulfonyl fluoride; PAGE, PA-gel electrophoresis; Nt, N-terminal regulatory domain (aa 1–128) of Aurora-A; Cd, C-terminal catalytic domain (aa 129–403)
Roles of the two type II NADH dehydrogenases in the survival of Mycobacterium tuberculosis in vitro
Keywords: نوع وحشی; TB, tuberculosis; Mtb, Mycobacterium tuberculosis; MDR/XDR, multiple/extremely drug resistant Mtb; NDH, NADH dehydrogenase; MoA, mechanism of action; INH, isoniazid; KO, knockout; SCO, single cross-over; DCO, double cross-over; WT, wild type; RT-PCR, reve
Reciprocal effects between microRNA-140-5p and ADAM10 suppress migration and invasion of human tongue cancer cells
Keywords: نوع وحشی; ADAM10, A disintegrin and metalloproteinase 10; TSCC, tongue squamous cell carcinoma; miRNA, microRNA; UTR, untranslated region; WT, wild type; MUT, mutant; siADAM10, siRNAs against ADAM10; ERBB4, v-erb-b2 avian erythroblastic leukemia viral oncogene homo