Comparison of amniotic and intramembranous unidirectional permeabilities in late-gestation sheep

Solute transport across the ovine amnion depends on solute size and appears to be limited only by the amnion's passive diffusional properties. In vivo intramembranous transport similarly depends on solute size but is not exclusively a passive diffusional process because it is primarily unidirectional outward from the amniotic fluid. Although it is a major barrier, the amnion is not the only barrier and does not appear to be responsible for the unidirectional nature of intramembranous absorption. Thus, unidirectionality appears to be imparted by nonpassive mechanisms in non-amnion tissues, which most likely includes vesicular transport within the endothelial cells of the intramembranous microvessels.