کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10044590 1596247 2005 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Increased expression of epidermal growth factor receptors in the tracheal epithelia after topical mitomycin-C in rabbits
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی پزشکی و دندانپزشکی (عمومی)
پیش نمایش صفحه اول مقاله
Increased expression of epidermal growth factor receptors in the tracheal epithelia after topical mitomycin-C in rabbits
چکیده انگلیسی
The aim is to examine histopathological changes and expression of epidermal growth factor receptor (EGFR) in tracheal epithelia caused by application of topical mitomycin-C (MMC) in rabbit model after the tracheotomy procedure. The conventional tracheotomy was performed in 16 rabbits. They were randomly divided into two equal groups. The first group was applied MMC at a concentration of 0.4 mg/ml around tracheotomy for 5 min, and the other group was not taken a treatment as a control. The animals were sacrificed at the end of 4 weeks. Their tracheas were evaluated with H&E and Masson's trichrome histochemically, and with antiepidermal growth factor receptor immunohistochemically. Results showed that there was no significant difference between MMC and control group for inflammatory cells (P = 0.09). The numbers of fibroblasts and subepithelial tissue thickness in the group exposed to MMC were significantly lower than the control group (P < 0.05). In contrast, the percentage of EGFR in the application of MMC group was significantly higher than the control group (P < 0.05). The application of topical MMC on airway epithelia after tracheotomy showed significant elevation in the levels of epithelial EGFR expression compared to controls in a rabbit model. The activation of epithelial EGFR may facilitate epithelial healing, but further studies are needed to assess the effect of topical MMC on respiratory epithelia.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Auris Nasus Larynx - Volume 32, Issue 1, March 2005, Pages 65-70
نویسندگان
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