کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10047790 | 1598410 | 2005 | 13 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Salt intake and progression of chronic kidney disease: An overlooked modifiable exposure? A commentary
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
بیماریهای کلیوی
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چکیده انگلیسی
The relationship between sodium chloride (salt) intake and blood pressure and cardiovascular disease has been debated for decades. Overlooked is whether there is a relationship between dietary electrolyte ingestion (both sodium and potassium) and risk for progression of kidney disease, particularly in patients who manifest early evidence of chronic kidney disease (CKD). Patients with CKD often are salt sensitive and respond to increased ingestion of sodium chloride with increased blood pressure. Of concern is the clinical evidence that salt-sensitive patients respond to increased salt intake, in the physiological range, with increased glomerular filtration fraction and proteinuria. Thus, these salt-induced changes in both systemic blood pressure and the renal microcirculation create a favorable theoretical scenario for progressive renal injury. Increased salt intake also attenuates the antihypertensive effects of most antihypertensive drugs. Consequently, salt intake must be considered a potential modifiable risk factor for the progression of kidney disease.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: American Journal of Kidney Diseases - Volume 45, Issue 1, January 2005, Pages 176-188
Journal: American Journal of Kidney Diseases - Volume 45, Issue 1, January 2005, Pages 176-188
نویسندگان
Matthew R. MD, Jeffrey C. MD,