NEOADJUVANT METHOTREXATE, VINBLASTINE, DOXORUBICIN AND CISPLATIN FOR HISTOLOGICALLY PROVEN LYMPH NODE POSITIVE BLADDER CANCER

Response to chemotherapy is associated with improved survival, and our data suggest that lymph node status after methotrexate, vinblastine, doxorubicin and cisplatin is more important than local tumor status in this aspect. In the absence of reliable noninvasive methods, post-chemotherapy surgery in this series was the most adequate method of response evaluation and in limited partial responders led to long-term progression-free survival.