Antioxidant Supplements Prevent Oxidation of Cysteine/Cystine Redox in Patients With Age-Related Macular Degeneration

The AREDS antioxidant supplements reduced oxidation of Eh Cys but had no effect on GSH. Because Cys is important for cell growth, apoptosis, and immune function, the beneficial effect of antioxidant supplementation on progression to advanced AMD may be partially explained by its effect on Eh Cys and/or its effect on Cys availability.