Silicone Versus Collagen Plugs for Treating Dry Eye: Results of a Prospective Randomized Trial Including Lacrimal Scintigraphy

Collagen and silicone plugs both resulted in significant increases in aqueous tear volume, half-life of nuclear material on the ocular surface, and percentage of nuclear material retention. The groups' post-insertion values for all parameters were similar. These results suggest that these two plug types have similar efficacy as treatments for dry eye in the short term. Further studies evaluating long-term results are required.