Stressing the Seminal Role of Paternal Experience in Transgenerational 'Epigenopathy' Affecting Offspring Health and Disease Susceptibility

- Pre-conceptual paternal stress has intergenerational effects on rodent offspring.
- Paternal stress affects neuronal morphology in the cerebral cortex of adult offspring.
- The paternal envirome modulates epigenetic inheritance of acquired traits in rodents.
- 'Epigenopathy' is introduced and defined as pathological epigenetic modifications.
- A future priority is the prevention of transgenerational transmission of epigenopathy.