The functions of sarcopenia related myokines

Skeletal muscle is not only responsible for locomotion, but also a major metabolism and endocrine organ. Skeletal muscle produces several secreted factors to regulate the microenvironment of both muscle and the whole body. The changing profile of myokines functions in the process of sarcopenia, the progressive loss of muscle mass and strength upon aging. Here we briefly review the current studies on the secreted factors produced by skeletal muscle and their functions in the process of sarcopenia.