کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10138286 | 1645886 | 2019 | 32 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Basolateral amygdala inactivation eliminates fear-induced underestimation of time in a temporal bisection task
ترجمه فارسی عنوان
غیرفعال کردن آمیگدال ناشی از بطن چپ از برآورد ترس ناشی از زمان در یک کار روزمره حذف می کند
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کلمات کلیدی
زمان بندی فاصله، ترس آمیگدالا، وظیفه زمان باریک، ادراک زمان،
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب رفتاری
چکیده انگلیسی
We examined interval timing - time perception in the seconds-to-minutes range - of the fear-inducing stimulus and the role of the amygdala in this phenomenon. Rats were initially trained to perform a temporal bisection task, in which their responses to levers A and B were reinforced following 2-s and 8-s tones, respectively. After acquisition, the rats were also presented with tones of intermediate durations and pressed one of the two levers to indicate whether the tone duration was closer to 2 or 8âs. Subsequently, the rats underwent differential fear conditioning, in which one frequency tone (conditioned stimulus; CS+) was paired with an electric foot shock, whereas another frequency tone (CSâ) was presented alone. The rats were then infused with artificial cerebrospinal fluid (aCSF) or the GABAA agonist muscimol into the bilateral basolateral amygdala (BLA) before performing the bisection task with CS+ and CSâ. In rats infused with aCSF, the psychophysical function shifted rightward in CS+ relative to that in CSâ. Moreover, the point of subjective equality of the CS+ was higher than that of CSâ, suggesting that the duration of the fear âCS was perceived as shorter than that of the neutral CS. However, muscimol infusion into the BLA abolished this difference, suggesting that BLA inactivation suppresses the effect of the fear âCS. Our results demonstrate that normal BLA activity is essential for fear-induced underestimation of time.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Behavioural Brain Research - Volume 356, 1 January 2019, Pages 227-235
Journal: Behavioural Brain Research - Volume 356, 1 January 2019, Pages 227-235
نویسندگان
Taisuke Kamada, Toshimichi Hata,