کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10157757 | 1666479 | 2019 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Combined Metabolo-Volumetric Parameters of 18F-FDG-PET and MRI Can Predict Tumor Cellularity, Ki67 Level and Expression of HIF 1alpha in Head and Neck Squamous Cell Carcinoma: A Pilot Study
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موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
تحقیقات سرطان
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
BACKGROUND: Our purpose was to evaluate associations of combined 18F-FDG-PET and MRI parameters with histopathological features in head and neck squamous cell carcinoma (HNSCC). METHODS: Overall, 22 patients with HNSCC were acquired (10 with G1/2 tumors and 12 with G3 tumors).18F-FDG-PET/CT and MRI was performed and maximum standardized uptake value (SUVmax), total lesion glycolysis (TLG) and metabolic tumor volume (MTV) were estimated. Neck MRI was obtained on a 3 T scanner. Diffusion weighted imaging was performed with estimation of apparent diffusion coefficient (ADC). Perfusion parameters Ktrans,Ve, and Kep were derived from dynamic contrast-enhanced (DCE) imaging. Different combined PET/MRI parameters were calculated as ratios: PET parameters divided by ADC or DCE MRI parameters. The following histopathological features were estimated: Ki 67, EGFR, VEGF, p53, hypoxia-inducible factor (HIF)-1α, and cell count. Spearman's correlation coefficient (p) was used for correlation analysis. P < .05 was taken to indicate statistical significance. RESULTS: In overall sample, cellularity correlated with SUVmax/ADCmin (Pâ¯=â¯.558, Pâ¯=â¯.007), TLG/ADCmin (Pâ¯=â¯.546, Pâ¯=â¯.009), and MTV/ADCmin (Pâ¯=â¯.468, Pâ¯=â¯.028). MTV/Kep correlated with expression of HIF-1α (Pâ¯=â¯.450, Pâ¯=â¯0,047). In G1/2 tumors, SUVmax/ADCmin correlated with HIF-1α (Pâ¯=â¯â.648, Pâ¯=â¯.043); MTV/Kep (Pâ¯=â¯â.669, Pâ¯=â¯.034) and TLG/Kep (Pâ¯=â¯â.644, Pâ¯=â¯.044) with Ki67. In G3 tumors, cellularity correlated with SUVmax/ADCmin (Pâ¯=â¯.832, Pâ¯=â¯.001), SUVmax/ADCmean (Pâ¯=â¯.741, Pâ¯=â¯.006), and TLG/ADCmin (Pâ¯=â¯.678, Pâ¯=â¯.015). MTV/ADCmin and TLG/ADCmin tended to correlate with HIF-1α. CONCLUSION: Combined parameters of 18F-FDG-PET and MRI can reflect Ki 67, tumor cellularity and expression of HIF-1α in HNSCC. Associations between parameters of 18F-FDG-PET and MRI and histopathology depend on tumor grading.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Translational Oncology - Volume 12, Issue 1, January 2019, Pages 8-14
Journal: Translational Oncology - Volume 12, Issue 1, January 2019, Pages 8-14
نویسندگان
Alexey Surov, Hans Jonas Meyer, Anne Kathrin Höhn, Osama Sabri, Sandra Purz,