Stężenie cholesterolu nie-HDL u nastolatków obciÄ Å¼onych klinicznymi czynnikami ryzyka miażdżycy

The main marker of atherogenesis is the level of LDL-ch. The level of non-HDL-ch is also perceived as being important in adults.AimThe evaluation of non-HDL-ch in teenagers with clinical risk factors for atherosclerosis (obesity or obesity and hypertension).Materials and MethodsThe study involved 68 participants aged 10-17: 33 obese (O) and 35 with obesity and hypertension (ON). The level of non-HDL-ch was calculated (total cholesterol level - HDL-ch level). Its value was regressed against age, body mass, BMI, sex, and clinical risk factors mentioned above. On the basis of literature, the following concentrations of non-HDL-ch were used: <3,1 mmol/l - normal, 3,1-3,6 mmol/l - borderline high, and >3,6 mmol/l - high.ResultsNormal non-HDL-ch levels, when analysed collectively, were significantly more prevalent in obese teenagers than in the group ON (60% vs. 40%). Borderline high and high levels were more prevalent in the group ON than in the O group (67.9% vs. 32.1%) (p = 0.024), the same pattern was visible when analysing only boys (83.3% vs. 16.7% p = 0.027). The cholesterol and its fraction levels, including non-HDL-ch, did not differ significantly in subgroups defined by sex and clinical diagnosis. No correlation was found between these levels and age, body mass, or BMI of the study's participants.Conclusions1.The level of non-HDL-ch seems to be related to clinical risk factors of atherosclerosis in teenagers - obesity or obesity with hypertension - although it does not differentiate the degree of the risk univocally.2.The usefulness of non-HDL-ch in everyday paediatric practice requires further research.